CAJ | 학술논문

目的：探究HIF-1α在胃癌患者血清中表达以及术后复发的相关性,明确HIF-1α在胃癌术后复发预后中的意义。方法选取于我院行胃癌根治术后复发的患者80例为观察组,术后5年及5年以上无复发患者50例为对照组。对比2组患者HIF-1α的免疫组化情况、VEGF表达情况,分析HIF-1α与VEGF和胃癌复发的相关性。结果观察组胃组织中HIF-1α、VEGF表达阳性率分别为77.50%、73.75%,显著高于对照组12.00%、10.00%。经单因素分析可知,胃癌的癌症相关性指标与VEGF以及HIF-1α具有相关性。 Spearman分析法进行分析,发现肿瘤复发性与VEGF、HIF-1α呈正相关(r=0.458,P=0.000)；HIF-1α阳性组1年生存率为45.16%,平均生存时间为(8.62±2.32)个月,显著低于阴性组1年生存率77.77%及平均生存时间(18.96±3.14)个月。 Cox分析法对胃癌进行风险模型分析发现VEGF与HIF-1α的表达是本病复发的高危因素。结论 HIF-1α与VEGF在胃组织中的表达与胃癌复发有着非常密切的关系,可以作为评价胃癌复发的相关指标。
목적：탐구HIF-1α재위암환자혈청중표체이급술후복발적상관성,명학HIF-1α재위암술후복발예후중적의의。방법선취우아원행위암근치술후복발적환자80례위관찰조,술후5년급5년이상무복발환자50례위대조조。대비2조환자HIF-1α적면역조화정황、VEGF표체정황,분석HIF-1α여VEGF화위암복발적상관성。결과관찰조위조직중HIF-1α、VEGF표체양성솔분별위77.50%、73.75%,현저고우대조조12.00%、10.00%。경단인소분석가지,위암적암증상관성지표여VEGF이급HIF-1α구유상관성。 Spearman분석법진행분석,발현종류복발성여VEGF、HIF-1α정정상관(r=0.458,P=0.000)；HIF-1α양성조1년생존솔위45.16%,평균생존시간위(8.62±2.32)개월,현저저우음성조1년생존솔77.77%급평균생존시간(18.96±3.14)개월。 Cox분석법대위암진행풍험모형분석발현VEGF여HIF-1α적표체시본병복발적고위인소。결론 HIF-1α여VEGF재위조직중적표체여위암복발유착비상밀절적관계,가이작위평개위암복발적상관지표。
Objective To study the expression of HIF-1αand and its correlation with gastric cancer recurrence, and to identify its prog-nosis evaluation in gastric cancer recurrence. Methods 80 patients with gastric cancer recurrence after radical surgery were selected as the observation group, and 50 patients without gastric cancer recurrence 5 or more than 5 years after surgery were selected as the control group. The immunohistochemical situation and expression of VEGF of the two groups were compared, and the correlation of HIF-1αand VEGF and gastric cancer recurrence were analyzed. Results The positive expression rate of HIF-1αand VEGF were 77. 50% and 73. 75% respectively in the observation group, which were significantly higher than 12. 00% and 10. 00% in the control group. Univariate analysis showed that the related indices such as degree of differentiation, depth of invasion, lymph node metastasis, vascular invasion, and TNM clinical stage were associated with VEGF expression and positive expression of HIF-1α. The Spearman correlation analysis showed that HIF-1α and VEGF was positively correlated (r=0. 458,P=0. 000). 1-year survival rate of HIF-1α-positive group was 45. 16%, and the average survival time was (8. 62 ± 2. 32) months, which was significantly lower than 77. 77% and (18. 96 ± 3. 14) months respectively in the negative group. Cox risk model analysis showed that HIF-1αand VEGF expression were high risk factors for gastric cancer recurrence. Conclusion HIF-1αand VEGF expression have a very colse correlation with gastric cancer recurrence, and it can be used as evaluation of gastric cancer recurrence and prognosis.