中国卒中杂志
中國卒中雜誌
중국졸중잡지
CHINESE JOURNAL OF STROKE
2015年
7期
612-615
,共4页
神经干细胞%神经前体细胞%缺氧诱导因子-1α%血管内皮生长因子%促红细胞生成素%一氧化氮合酶%内环境
神經榦細胞%神經前體細胞%缺氧誘導因子-1α%血管內皮生長因子%促紅細胞生成素%一氧化氮閤酶%內環境
신경간세포%신경전체세포%결양유도인자-1α%혈관내피생장인자%촉홍세포생성소%일양화담합매%내배경
Neural stem cell%Neural precursor cell%Hypoxia-inducible factor 1α%Vascular endothelial growth factor%Erythropoietin%Nitric oxide synthase%Microenvironment
目前脑缺血后促进内源性神经干细胞（neural stem cels，NSCs）再生的影响因素已成为神经病学研究的热点。近年来，有实验证明一些相关因子在脑梗死后缺血缺氧条件下被高度表达并参与了脑组织损伤的修复过程，如缺氧诱导因子-1α（hypoxia-inducible factor-1α，HIF-1α）。许多研究利用大鼠脑缺血模型进行免疫组化和蛋白印迹分析来评估内源性NSCs与HIF-1α早期表达的关系，结果表明在缺血造成的内环境中，HIF-1α的早期表达能够使内源性NSCs促进神经细胞的再生。而且脑梗死后， HIF-1α在缺血缺氧的环境中高度表达并发挥神经保护作用，为脑损伤的修复提供了有利的基础条件。
目前腦缺血後促進內源性神經榦細胞（neural stem cels，NSCs）再生的影響因素已成為神經病學研究的熱點。近年來，有實驗證明一些相關因子在腦梗死後缺血缺氧條件下被高度錶達併參與瞭腦組織損傷的脩複過程，如缺氧誘導因子-1α（hypoxia-inducible factor-1α，HIF-1α）。許多研究利用大鼠腦缺血模型進行免疫組化和蛋白印跡分析來評估內源性NSCs與HIF-1α早期錶達的關繫，結果錶明在缺血造成的內環境中，HIF-1α的早期錶達能夠使內源性NSCs促進神經細胞的再生。而且腦梗死後， HIF-1α在缺血缺氧的環境中高度錶達併髮揮神經保護作用，為腦損傷的脩複提供瞭有利的基礎條件。
목전뇌결혈후촉진내원성신경간세포（neural stem cels，NSCs）재생적영향인소이성위신경병학연구적열점。근년래，유실험증명일사상관인자재뇌경사후결혈결양조건하피고도표체병삼여료뇌조직손상적수복과정，여결양유도인자-1α（hypoxia-inducible factor-1α，HIF-1α）。허다연구이용대서뇌결혈모형진행면역조화화단백인적분석래평고내원성NSCs여HIF-1α조기표체적관계，결과표명재결혈조성적내배경중，HIF-1α적조기표체능구사내원성NSCs촉진신경세포적재생。이차뇌경사후， HIF-1α재결혈결양적배경중고도표체병발휘신경보호작용，위뇌손상적수복제공료유리적기출조건。
Influence factors of promoting the regeneration of endogenous neural stem cells (NSCs) after cerebral infarction are becoming a hot spot of concern for neurological scholars. In recent years, some experiments have been proven that some related factors involved in the brain tissue damage repair process and got highly expressed in the condition of ischemia and hypoxia after cerebral infarction, such as hypoxia-inducible factor-1α (HIF-1α). Experts evaluated the relationships between endogenous NSCs and HIF-1α expression in a photothromobotic rat stroke model using immunohistochemistry and Western blot analysis. The results showed that early expressions of HIF-1α after ischemia made up the microenvironment to increase the nerve regeneration for endogenous NSCs. A large number of studies have shown that high expressions of HIF-1α protect nerve cells from damage after cerebral ischemia in ischemic and anoxic environment and provide the favorable conditions for brain repair.
