CAJ | 학술논문

目的对影响慢加急性肝衰竭(ACLF)伴肝性脑病(HE)患者预后的因素进行分析,探讨影响预后的危险因素.方法回顾性分析159例ACLF伴HE患者的临床资料,以确定HE为起点,将患者分为生存组(13例)和死亡组(146例),选择32个相关临床指标,用SPSS软件对相关数据进行单因素和多因素非比例风险的Cox模型分析.结果 ACLF伴HE患者1、3、6个月的生存率分别为20.13％、10.06％、8.18％,经Cox回归分析,筛选出HE分期、肝肾综合征(HRS)为独立的预后因素(x2=18.344、11.368,均P＜0.05),HE分期越高、出现HRS增加患者死亡风险,相对危险度(RR)分别为1.591、1.809.结论 HE分期、HRS是判断ACLF伴HE患者预后的重要指标.
목적 대영향만가급성간쇠갈(ACLF)반간성뇌병(HE)환자예후적인소진행분석,탐토영향예후적위험인소.방법 회고성분석159례ACLF반HE환자적림상자료,이학정HE위기점,장환자분위생존조(13례)화사망조(146례),선택32개상관림상지표,용SPSS연건대상관수거진행단인소화다인소비비례풍험적Cox모형분석.결과 ACLF반HE환자1、3、6개월적생존솔분별위20.13％、10.06％、8.18％,경Cox회귀분석,사선출HE분기、간신종합정(HRS)위독립적예후인소(x2=18.344、11.368,균P＜0.05),HE분기월고、출현HRS증가환자사망풍험,상대위험도(RR)분별위1.591、1.809.결론 HE분기、HRS시판단ACLF반HE환자예후적중요지표.
Objective To analyze the prognostic factors for patients with hepatic encephalopathy (HE) in acute-on-chronic liver failure(ACLF).Methods A retrospective analysis was performed on 159 ACLF patients with HE.The hepatic encephalopathy was determined to baseline,the patients were divided into survivors(n =13) and nonsurvivors(n =146),The 32 factors affecting the prognosis were analyzed by Cox proportional hazard model with SPSS.Results One-month,three-month,and six-month survival rates were 20.13％,10.06％ and 8.18％,respectively.Cox regression analysis of prognostic factors showed that it could the stage of hepatic encephalopathy and HRS significantly improve the survival rate of the patients with HE in acute-on-chronic liver failure.The stage of hepatic encephalopathy and HRS could significantly decrease the survival rate of the patients(x2 =18.344,11.368,all P ＜ 0.05),elevated the levels of hepatic encephalopathy (relative risk (RR) =1.591) and HRS (RR =1.809) indicate worse prognosis with hepatic encephalopathy in acute-on-chronic failure.Conclusion The stage of hepatic encephalopathy and HRS were independent risk factor sof prognosis in acute-on-chronic liver failure.