中国基层医药
中國基層醫藥
중국기층의약
CHINESE JOURNAL OF PRIMARY MEDICINE AND PHARMACY
2015年
9期
1284-1286
,共3页
结核,喉%淋巴细胞%淋巴因子%流行病学
結覈,喉%淋巴細胞%淋巴因子%流行病學
결핵,후%림파세포%림파인자%류행병학
Tuberculosis,Laryngeal%Lymphocytes%Lymphokines%Epidemiology
目的 探讨淋巴细胞与细胞因子在喉结核患者体内表达的临床意义.方法 筛选96例喉结核患者作为研究对象,其中浸润型42例,溃疡型31例,肿块型23例,另选取同期体检健康人员50例,作为健康对照组,抽取所有研究对象清晨空腹外周静脉血进行T淋巴细胞亚群及细胞因子检测,并对比各组检测结果.结果 浸润型喉结核CD3+为(63.10 ±5.33)％、CD4+为(40.32±5.06)％、CD8+为(24.41±4.59)％,与对照组比较CD3+、CD4+指标显著降低,CD8+指标明显上升,差异均有统计学意义(t=1.922、1.758、1.710,均P＜0.05),并且溃疡型与肿块型、浸润型结果比较差异均有统计学意义(均P＜0.05).而在喉结核病理类型分析中,肿块型CD3+、CD4+T淋巴细胞指标降低及CD8+指标明显升高;所有喉结核患者IL-4、IL-10及TNF-α明显较对照组升高,而IFN-γ明显降低,并且以肿块型变化最为显著,差异均有统计学意义(均P＜0.05).结论 采用淋巴细胞及细胞因子检测可提高喉结核患者的临床确诊率,并且不同病理分型的喉结核患者有不同的检测结果,可用于喉结核病情及病理分型的初步评估,对患者治疗方式的选择有指导价值,具有临床深入研究及推广应用的价值.
目的 探討淋巴細胞與細胞因子在喉結覈患者體內錶達的臨床意義.方法 篩選96例喉結覈患者作為研究對象,其中浸潤型42例,潰瘍型31例,腫塊型23例,另選取同期體檢健康人員50例,作為健康對照組,抽取所有研究對象清晨空腹外週靜脈血進行T淋巴細胞亞群及細胞因子檢測,併對比各組檢測結果.結果 浸潤型喉結覈CD3+為(63.10 ±5.33)％、CD4+為(40.32±5.06)％、CD8+為(24.41±4.59)％,與對照組比較CD3+、CD4+指標顯著降低,CD8+指標明顯上升,差異均有統計學意義(t=1.922、1.758、1.710,均P＜0.05),併且潰瘍型與腫塊型、浸潤型結果比較差異均有統計學意義(均P＜0.05).而在喉結覈病理類型分析中,腫塊型CD3+、CD4+T淋巴細胞指標降低及CD8+指標明顯升高;所有喉結覈患者IL-4、IL-10及TNF-α明顯較對照組升高,而IFN-γ明顯降低,併且以腫塊型變化最為顯著,差異均有統計學意義(均P＜0.05).結論 採用淋巴細胞及細胞因子檢測可提高喉結覈患者的臨床確診率,併且不同病理分型的喉結覈患者有不同的檢測結果,可用于喉結覈病情及病理分型的初步評估,對患者治療方式的選擇有指導價值,具有臨床深入研究及推廣應用的價值.
목적 탐토림파세포여세포인자재후결핵환자체내표체적림상의의.방법 사선96례후결핵환자작위연구대상,기중침윤형42례,궤양형31례,종괴형23례,령선취동기체검건강인원50례,작위건강대조조,추취소유연구대상청신공복외주정맥혈진행T림파세포아군급세포인자검측,병대비각조검측결과.결과 침윤형후결핵CD3+위(63.10 ±5.33)％、CD4+위(40.32±5.06)％、CD8+위(24.41±4.59)％,여대조조비교CD3+、CD4+지표현저강저,CD8+지표명현상승,차이균유통계학의의(t=1.922、1.758、1.710,균P＜0.05),병차궤양형여종괴형、침윤형결과비교차이균유통계학의의(균P＜0.05).이재후결핵병리류형분석중,종괴형CD3+、CD4+T림파세포지표강저급CD8+지표명현승고;소유후결핵환자IL-4、IL-10급TNF-α명현교대조조승고,이IFN-γ명현강저,병차이종괴형변화최위현저,차이균유통계학의의(균P＜0.05).결론 채용림파세포급세포인자검측가제고후결핵환자적림상학진솔,병차불동병리분형적후결핵환자유불동적검측결과,가용우후결핵병정급병리분형적초보평고,대환자치료방식적선택유지도개치,구유림상심입연구급추엄응용적개치.
Objective To investigate the clinical significance of the expression of lymphocytes and cytokines in patients with laryngeal tuberculosis.Methods 96 cases of laryngeal tuberculosis were selected as the research objects.Of which 42 cases of infiltrating type,31 cases of ulcer type,mass type in 23 cases,the other 50 cases of healthy persons were selected as the healthy control group,all the research objects,extracting the morning fasting venous peripheral blood for detection of T lymphocyte subsets and cytokines were detected,and the results were compared.Results Invasive laryngeal tuberculosis CD3+ index (63.10 ± 5.33) ％ (t =1.922),CD4+ (40.32 ± 5.06) ％ (t =1.758),CD8+ (24.41 ± 4.59) ％ (t =1.710),compared with the control group,CD4+,CD3+ index significantly reduced,CD8+ index increased significantly,the differences had statistical significance (t =1.922,1.758,1.710,all P ＜ 0.05),and the ulcer type and mass type results compared with invasive had significant difference(all P ＜0.05).In the analysis of laryngeal tuberculosis pathological types,reduced the mass type CD3+,CD4+ T index and CD8+ index of lymphocyte increased obviously the most significant;all laryngeal tuberculosis in patients with IL-4,IL-10 and TNF-alpha significantly increased compared with the control group,while the IFN-gamma was significantly reduced,and the mass in the type of change was the most significant,the differences had statistical significance(all P ＜ 0.05).Conclusion The use of lymphocytes and cytokines detection can improve the laryngeal tuberculosis patients with the clinical diagnosis rate,with the detection results of different degree and different pathological types of laryngeal tuberculosis patients,can be used for preliminary assessment of laryngeal tuberculosis disease and pathological type,the choice of treatment modality for patients with guidance value,with in-depth clinical study and promotion application of value.
