CAJ | 학술논문

目的：探讨小儿肺热咳喘口服液对小儿毛细支气管炎Th1/Th2细胞的影响。方法选择2013年9月—2014年12月北京市昌平区中西医结合医院儿科收治的毛细支气管炎住院患儿80例，按随机数字表法分为试验组和对照组，各40例。根据临床用药指南，两组患儿均给予抗感染和对症治疗，对照组患儿静脉滴注头孢曲松钠治疗，治疗组患儿在对照组基础上给予小儿肺热咳喘口服液治疗，疗程均为7d。比较两组患儿临床疗效，治疗前后干扰素γ（IFN-γ）、白介素4（IL-4）水平及Th1细胞分数、Th2细胞分数、Th1/Th2细胞百分比变化，并观察治疗期间两组患儿不良反应发生情况。结果试验组患儿临床疗效优于对照组（ P﹤0.05）。治疗前两组患儿血清IFN-γ、IL-4水平及Th1细胞分数、Th2细胞分数、Th1/Th2细胞百分比比较，差异无统计学意义（ P﹥0.05）；治疗后试验组患儿血清IFN-γ、IL-4水平及Th1细胞分数、Th2细胞分数、Th1/Th2细胞百分比低于对照组（ P﹤0.05）。结论小儿肺热咳喘口服液治疗毛细支气管炎患儿临床疗效良好，可通过调节Th1/Th2细胞而增加患儿免疫功能。
목적：탐토소인폐열해천구복액대소인모세지기관염Th1/Th2세포적영향。방법선택2013년9월—2014년12월북경시창평구중서의결합의원인과수치적모세지기관염주원환인80례，안수궤수자표법분위시험조화대조조，각40례。근거림상용약지남，량조환인균급여항감염화대증치료，대조조환인정맥적주두포곡송납치료，치료조환인재대조조기출상급여소인폐열해천구복액치료，료정균위7d。비교량조환인림상료효，치료전후간우소γ（IFN-γ）、백개소4（IL-4）수평급Th1세포분수、Th2세포분수、Th1/Th2세포백분비변화，병관찰치료기간량조환인불량반응발생정황。결과시험조환인림상료효우우대조조（ P﹤0.05）。치료전량조환인혈청IFN-γ、IL-4수평급Th1세포분수、Th2세포분수、Th1/Th2세포백분비비교，차이무통계학의의（ P﹥0.05）；치료후시험조환인혈청IFN-γ、IL-4수평급Th1세포분수、Th2세포분수、Th1/Th2세포백분비저우대조조（ P﹤0.05）。결론소인폐열해천구복액치료모세지기관염환인림상료효량호，가통과조절Th1/Th2세포이증가환인면역공능。
Objective To explore the impact of xiaoer-feire-kechuan oral solution on Th1/Th2 cells of infants with bronchiolitis. Methods A total of 80 infants with bronchiolitis that hospitalized in Department of Pediatrics,Integrated Chinese and Western Medicine Hospital of Changping District were selected from September 2013 to December 2014 , and they were divided into experiment group and control group according to random number table,each of 40 cases. Infants of both groups were given anti-infectious therapy and symptomatic treatment according to clinical medication guides,and infants of control group were given extra intravenous drip of ceftriaxone sodium, while infants of experiment group were given extra xiaoer - feire -kechuan oral solution based on the treatment of control group,both groups treated for 7 days. Clinical effect,serum levels of IFN-γand IL-4,Th1 cell counts,Th2 cell counts and Th1/Th2 cell percentage before and after treatment were compared between the two groups, and incidence of adverse reactions were observed. Results The clinical effect of experiment group was statistically significantly better than that of control group ( P﹤0. 05 ). No statistically significant differences of serum levels of IFN-γ and IL-4,Th1 cell counts,Th2 cell counts or Th1/Th2 cell percentage were found between the two groups before treatment(P﹥0. 05);while serum levels of IFN-γand IL-4,Th1 cell counts,Th2 cell counts and Th1/Th2 cell percentage of experiment group were lower than those of control group after treatment ( P﹤0. 05 ). Conclusion Xiaoer-feire-kechuan oral solution can has a certainly good clinical effect on bronchiolitis in infants,it may adjust Th1/Th2 cells to improve the immune function.