CAJ | 학술논문

葡萄膜炎是一类发生于葡萄膜、视网膜、视网膜血管及玻璃体的炎症.Behcet病和Vogt-小柳原田综合征是我国常见且致盲率较高的2种葡萄膜炎类型,其发病机制复杂,涉及遗传和环境因素的相互作用.长期以来,与人类白细胞抗原(HLA)的显著相关性是遗传背景参与多种葡萄膜炎类型发生的最重要证据.近年来,随着新技术的发展和研究的深入,利用候选基因法发现多种免疫相关基因的多态性与Behcet病和Vogt-小柳原田综合征的发生相关,如IL-23R、IL-17、miR-146a等;利用全基因相关分析的方法全面分析了遗传因素在这2种疾病发生中的作用.现就发现的汉族人群Behcet病和Vogt-小柳原田综合征相关遗传易感因素的研究进展做一综述.
포도막염시일류발생우포도막、시망막、시망막혈관급파리체적염증.Behcet병화Vogt-소류원전종합정시아국상견차치맹솔교고적2충포도막염류형,기발병궤제복잡,섭급유전화배경인소적상호작용.장기이래,여인류백세포항원(HLA)적현저상관성시유전배경삼여다충포도막염류형발생적최중요증거.근년래,수착신기술적발전화연구적심입,이용후선기인법발현다충면역상관기인적다태성여Behcet병화Vogt-소류원전종합정적발생상관,여IL-23R、IL-17、miR-146a등;이용전기인상관분석적방법전면분석료유전인소재저2충질병발생중적작용.현취발현적한족인군Behcet병화Vogt-소류원전종합정상관유전역감인소적연구진전주일종술.
Uveitis is a group of inflammatory conditions involving the uvea,retina,retinal vessel and vitreous.Behcet's disease and Vogt-Koyanagi-Harada (VKH) syndrome are two of the most common uveitis entities in China.The precise pathogenesis of both diseases remains to be elucidated,though genetic background and environmental factors are widely accepted to be involved in the development.The strong association of human lymphocyte antigens (HLA) with these two uveitis entities indicates the involvement of genetic background in the pathogenesis of these diseases.Several gene polymorphisms,such as IL-23R,IL-17 and miR-146a have been shown to be associated with Behcet's disease and VKH syndrome through candidate gene analysis.Genome-wide association study has also been used to analyze the effects of genetic factors on these two uveitis entities.The studies on genetic factors involved in Behcet's disease and VKH syndrome in Chinese Han population were reviewed in this article.