实用心脑肺血管病杂志
實用心腦肺血管病雜誌
실용심뇌폐혈관병잡지
PRACTICAL JOURNAL OF CARDIAC CEREBRAL PNEUMAL AND VASCULAR DISEASE
2015年
4期
80-81
,共2页
痴呆,血管性%丁苯酞软胶囊%尼莫地平%治疗结果
癡呆,血管性%丁苯酞軟膠囊%尼莫地平%治療結果
치태,혈관성%정분태연효낭%니막지평%치료결과
Dementia,vascular%Butylphthalide soft capsules%Nnimodipine%Treatment outcome
目的：探究丁苯酞软胶囊联合尼莫地平治疗血管性痴呆（ VD）的临床疗效和安全性。方法选取鹤壁市中医院神经内科2012年7月—2014年7月收治的VD患者129例，按照随机数字表法将患者分为对照组64例和观察组65例。在常规治疗基础上，对照组患者给予尼莫地平治疗，观察组患者在对照组基础上给予丁苯酞软胶囊治疗，两组患者均治疗12周。比较两组患者临床疗效，治疗前和治疗12周后简易智力状态检查量表（ MMSE）评分和日常生活能力量表（ ADL）评分，治疗期间药物不良反应发生情况。结果观察组患者临床疗效优于对照组（ P﹤0.05）。两组患者治疗前MMSE评分和ADL评分比较，差异无统计学意义（ P﹥0.05）；观察组患者治疗12周后MMSE评分和ADL评分均高于对照组（P﹤0.05）。两组患者不良反应发生率比较，差异无统计学意义（P﹥0.05）。结论丁苯酞软胶囊联合尼莫地平治疗VD的临床疗效确切，能有效改善患者痴呆症状及日常生活能力，且安全性高。
目的：探究丁苯酞軟膠囊聯閤尼莫地平治療血管性癡呆（ VD）的臨床療效和安全性。方法選取鶴壁市中醫院神經內科2012年7月—2014年7月收治的VD患者129例，按照隨機數字錶法將患者分為對照組64例和觀察組65例。在常規治療基礎上，對照組患者給予尼莫地平治療，觀察組患者在對照組基礎上給予丁苯酞軟膠囊治療，兩組患者均治療12週。比較兩組患者臨床療效，治療前和治療12週後簡易智力狀態檢查量錶（ MMSE）評分和日常生活能力量錶（ ADL）評分，治療期間藥物不良反應髮生情況。結果觀察組患者臨床療效優于對照組（ P﹤0.05）。兩組患者治療前MMSE評分和ADL評分比較，差異無統計學意義（ P﹥0.05）；觀察組患者治療12週後MMSE評分和ADL評分均高于對照組（P﹤0.05）。兩組患者不良反應髮生率比較，差異無統計學意義（P﹥0.05）。結論丁苯酞軟膠囊聯閤尼莫地平治療VD的臨床療效確切，能有效改善患者癡呆癥狀及日常生活能力，且安全性高。
목적：탐구정분태연효낭연합니막지평치료혈관성치태（ VD）적림상료효화안전성。방법선취학벽시중의원신경내과2012년7월—2014년7월수치적VD환자129례，안조수궤수자표법장환자분위대조조64례화관찰조65례。재상규치료기출상，대조조환자급여니막지평치료，관찰조환자재대조조기출상급여정분태연효낭치료，량조환자균치료12주。비교량조환자림상료효，치료전화치료12주후간역지력상태검사량표（ MMSE）평분화일상생활능역량표（ ADL）평분，치료기간약물불량반응발생정황。결과관찰조환자림상료효우우대조조（ P﹤0.05）。량조환자치료전MMSE평분화ADL평분비교，차이무통계학의의（ P﹥0.05）；관찰조환자치료12주후MMSE평분화ADL평분균고우대조조（P﹤0.05）。량조환자불량반응발생솔비교，차이무통계학의의（P﹥0.05）。결론정분태연효낭연합니막지평치료VD적림상료효학절，능유효개선환자치태증상급일상생활능력，차안전성고。
Objective To observe the clinical effect of butylphthalide soft capsule combined with nimodipine on vascular dementia. Methods From July 2012 to July 2014,a total of 129 patients with vascular dementia were selected in the Department of Neurology,Traditional Chinese Medicine Hospital of Hebi,and they were divided into control group(n =64) and observation group(n=65)according to random number table. Patients of both groups were given conventional therapy, while patients of control group were given extra nimodipine,patients of observation group were given extra butylphthalide soft capsule combined with nimodipine,both groups treated for 12 weeks. Clinical effect,MMSE score and ADL score before and after treatment,incidence of adverse reactions during treatment were compared between the two groups. Results The clinical effect of observation group was better than that of control group ( P ﹤0. 05 ). No statistically significant differences of MMSE score or ADL score was found between the two groups before treatment(P﹥0. 05);MMSE score and ADL score of observation group were significantly higher than those of control group after treatment ( P﹤0. 05 ). No statistically significant differences of incidence of adverse reactions was found between the two groups ( P ﹥ 0. 05 ). Conclusion Butylphthalide soft capsule combined with nimodipine has certain clinical effect on vascular dementia,can effectively relieve the patients' symptoms and improve the ability of daily living,and is safe.
