CAJ | 학술논문

目的：分析我院药品不良反应（ADR）的特点与规律，提高临床安全用药水平，促进合理用药。方法：对我院2011-2013年收集并上报至国家ADR监测中心的303例ADR报告进行分析。结果：在303例ADR报告中，男∶女为1∶1.13；60岁以上的人群占27.06%。以静脉滴注和口服给药为主，分别为224例（73.93%）和68例（22.44%）。抗菌药物ADR发生例数最多，共200例（66.01%）；中药注射剂ADR 17例（5.61%）。ADR累及器官或系统以皮肤及其附件和消化系统损害为主，分别为177例（58.42%）和54例（17.82%）。结论：加强临床ADR的监测和报告工作，应减少静脉用药，合理使用抗菌药物，重视ADR与临床用药的相关性。
목적：분석아원약품불량반응（ADR）적특점여규률，제고림상안전용약수평，촉진합리용약。방법：대아원2011-2013년수집병상보지국가ADR감측중심적303례ADR보고진행분석。결과：재303례ADR보고중，남∶녀위1∶1.13；60세이상적인군점27.06%。이정맥적주화구복급약위주，분별위224례（73.93%）화68례（22.44%）。항균약물ADR발생례수최다，공200례（66.01%）；중약주사제ADR 17례（5.61%）。ADR루급기관혹계통이피부급기부건화소화계통손해위주，분별위177례（58.42%）화54례（17.82%）。결론：가강림상ADR적감측화보고공작，응감소정맥용약，합리사용항균약물，중시ADR여림상용약적상관성。
Objective:To analyze the characteristics and regularity of ADRs in our hospital,improve safety medication and promote the rational drug use in clinical practice.Methods:Totally 303 cases of ADR reports col-lected and reported to the National ADR Monitoring Center from 2011 to 2013 were summarized in our hospital. Results:Among the ADR reports of 303 cases,the ratio of male to female was 1∶1.13 and 27.06% of ADRs oc-curred in the people over 60 years old. Totally 224 ADR cases(73.93%)were induced by intravenous administra-tion and 68 ADR cases(22.44%)were induced by oral administration. Totally 200 ADR cases were caused by an-tibacterial drugs(66.01%)and 17 ADR cases were caused by traditional Chinese medicine injections(5.61%). The main clinical manifestations were lesion of skin and its appendant organ(177 cases,58.42%)and digestive system injury(54 cases,17.82%).Conclusion:It is necessary to strengthen the monitoring and reporting of clini-cal ADR work,reduce intravenous drug use,improve the rational use of anti-infective drugs,and pay more atten-tion to the relativity of ADRs and clinical medication.