中国卒中杂志
中國卒中雜誌
중국졸중잡지
CHINESE JOURNAL OF STROKE
2015年
6期
483-487
,共5页
华法林%阿司匹林%心房颤动%低强度抗凝
華法林%阿司匹林%心房顫動%低彊度抗凝
화법림%아사필림%심방전동%저강도항응
Warfarin%Aspirin%Atrial ifbrillation%Low intensity anticoagulation
目的探讨低强度华法林在老年非瓣膜性心房颤动卒中高风险患者卒中一级预防中的疗效及安全性。<br> 方法本研究连续入组首都医科大学附属北京天坛医院2010年1月～2014年1月，心内科、老年科住院部及抗凝门诊确诊的治疗时间＞1年的非瓣膜性心房颤动卒中高风险患者80例，根据患者接受治疗情况分为低强度华法林治疗组和阿司匹林对照组各40例，其中华法林组控制凝血酶原时间国际标准化比值（international normalized ratio，INR）为1.6～2.5，比较两组患者缺血性卒中及全身大出血等不良反应的发生率。<br> 结果两组间在性别、年龄、伴随疾病等方面差异无显著性。低强度华法林治疗组心源性脑栓塞发生率为2.5%，阿司匹林治疗组为7.5%，两组比较差异无显著性（P＞0.05）。低强度华法林治疗组无其他部位栓塞发生，而阿司匹林治疗组患者其他部位栓塞仅1例，两组比较差异无显著性（P＞0.05）。两组均无心源性短暂性脑缺血发作发生。低强度华法林治疗组与阿司匹林治疗组均无严重脑出血、肾出血、其他器官出血等并发症发生。<br> 结论低强度华法林在非瓣膜性心房颤动卒中高风险患者卒中一级预防中疗效性与安全性方面可能与阿司匹林相当。
目的探討低彊度華法林在老年非瓣膜性心房顫動卒中高風險患者卒中一級預防中的療效及安全性。<br> 方法本研究連續入組首都醫科大學附屬北京天罈醫院2010年1月～2014年1月，心內科、老年科住院部及抗凝門診確診的治療時間＞1年的非瓣膜性心房顫動卒中高風險患者80例，根據患者接受治療情況分為低彊度華法林治療組和阿司匹林對照組各40例，其中華法林組控製凝血酶原時間國際標準化比值（international normalized ratio，INR）為1.6～2.5，比較兩組患者缺血性卒中及全身大齣血等不良反應的髮生率。<br> 結果兩組間在性彆、年齡、伴隨疾病等方麵差異無顯著性。低彊度華法林治療組心源性腦栓塞髮生率為2.5%，阿司匹林治療組為7.5%，兩組比較差異無顯著性（P＞0.05）。低彊度華法林治療組無其他部位栓塞髮生，而阿司匹林治療組患者其他部位栓塞僅1例，兩組比較差異無顯著性（P＞0.05）。兩組均無心源性短暫性腦缺血髮作髮生。低彊度華法林治療組與阿司匹林治療組均無嚴重腦齣血、腎齣血、其他器官齣血等併髮癥髮生。<br> 結論低彊度華法林在非瓣膜性心房顫動卒中高風險患者卒中一級預防中療效性與安全性方麵可能與阿司匹林相噹。
목적탐토저강도화법림재노년비판막성심방전동졸중고풍험환자졸중일급예방중적료효급안전성。<br> 방법본연구련속입조수도의과대학부속북경천단의원2010년1월～2014년1월，심내과、노년과주원부급항응문진학진적치료시간＞1년적비판막성심방전동졸중고풍험환자80례，근거환자접수치료정황분위저강도화법림치료조화아사필림대조조각40례，기중화법림조공제응혈매원시간국제표준화비치（international normalized ratio，INR）위1.6～2.5，비교량조환자결혈성졸중급전신대출혈등불량반응적발생솔。<br> 결과량조간재성별、년령、반수질병등방면차이무현저성。저강도화법림치료조심원성뇌전새발생솔위2.5%，아사필림치료조위7.5%，량조비교차이무현저성（P＞0.05）。저강도화법림치료조무기타부위전새발생，이아사필림치료조환자기타부위전새부1례，량조비교차이무현저성（P＞0.05）。량조균무심원성단잠성뇌결혈발작발생。저강도화법림치료조여아사필림치료조균무엄중뇌출혈、신출혈、기타기관출혈등병발증발생。<br> 결론저강도화법림재비판막성심방전동졸중고풍험환자졸중일급예방중료효성여안전성방면가능여아사필림상당。
Objective To explore the efifcacy and safety of low intensity warfarin in the elderly patients with nonvalvular atrial ifbrillation in the prevention of cerebral embolism. <br> Methods We consecutively enrolled 80 patients who were diagnosed nonvalvular atrial ifbrillation with treatment duration>1 year, admitted to Department of Cardiology and Department of Geriatrics of Beijing Tiantan Hospital from January 2010 to January 2014. The patients were divided into low intensity warfarin treatment group (40 patients) and aspirin treatment control group (40 patients), and international normalized ratio of low intensity warfarin treatment group was controlled within the range of 1.6~2.5. The incidence of ischemic stroke and major hemorrhage were compared between both groups. <br> Results There were no signiifcant differences between the two groups in age, sex and complications. The incidence of cardioembolic stroke in low intensity warfarin treatment group was 2.5%, 7.5% in aspirin treatment control group, there was no signiifcant difference (P>0.05). There were no other organ embolisms in low intensity warfarin treatment group, but only one in aspirin treatment control group, but with no signiifcant difference (P>0.05). There were no severe cerebral hemorrhage, renal hemorrhage, and bleeding from the other organs in both groups. <br> Conclusion Low-intensity warfarin in the prevention of stroke in patients with non-valvular atrial ifbrillation stroke in terms of efifcacy and safety may be comparable to aspirin.
