实用心脑肺血管病杂志
實用心腦肺血管病雜誌
실용심뇌폐혈관병잡지
PRACTICAL JOURNAL OF CARDIAC CEREBRAL PNEUMAL AND VASCULAR DISEASE
2015年
4期
72-74
,共3页
甲状腺功能亢进症%心房纤颤%普萘洛尔%丙硫氧嘧啶%治疗结果
甲狀腺功能亢進癥%心房纖顫%普萘洛爾%丙硫氧嘧啶%治療結果
갑상선공능항진증%심방섬전%보내락이%병류양밀정%치료결과
Hyperthyroidism%Atrial fibrillation%Propranolol%Propylthiouracil%Treatment outcome
目的：探讨丙硫氧嘧啶联合不同剂量普萘洛尔治疗甲状腺功能亢进症合并心房纤颤的临床疗效。方法选取2011年3月—2014年3月高安市人民医院内分泌科收治的甲状腺功能亢进症合并心房纤颤患者122例，采用随机数字表法将所有患者分为观察组和对照组，每组61例。两组患者均采用丙硫氧嘧啶治疗，观察组联合大剂量普萘洛尔治疗（30 mg/次，3次/d），对照组联合小剂量普萘洛尔治疗（10 mg/次，3次/d）。比较两组患者治疗前及治疗8周后心率、血压、左室射血分数（ LVEF）、游离三碘甲状腺原氨酸（ FT3）、游离甲状腺素（ FT4）和促甲状腺素（ TSH）及治疗3个月内不良反应和窦性心律转复情况。结果两组患者治疗前收缩压、舒张压、心率及LVEF比较，差异无统计学意义（P﹥0.05）；观察组患者治疗后收缩压、舒张压、心率均低于对照组，LVEF高于对照组（P﹤0.05）。两组患者治疗前FH3、FH4、TSH比较，差异无统计学意义（ P ﹥0.05）；观察组患者治疗后 FT3、FT4均低于对照组， TSH高于对照组（P﹤0.05）。两组患者不良反应发生率比较，差异无统计学意义（P﹥0.05）；观察组患者窦性心律转复率高于对照组（ P﹤0.05）。结论丙硫氧嘧啶联合大剂量普萘洛尔治疗甲状腺功能亢进症合并心房纤颤的临床疗效显著，安全性较好。
目的：探討丙硫氧嘧啶聯閤不同劑量普萘洛爾治療甲狀腺功能亢進癥閤併心房纖顫的臨床療效。方法選取2011年3月—2014年3月高安市人民醫院內分泌科收治的甲狀腺功能亢進癥閤併心房纖顫患者122例，採用隨機數字錶法將所有患者分為觀察組和對照組，每組61例。兩組患者均採用丙硫氧嘧啶治療，觀察組聯閤大劑量普萘洛爾治療（30 mg/次，3次/d），對照組聯閤小劑量普萘洛爾治療（10 mg/次，3次/d）。比較兩組患者治療前及治療8週後心率、血壓、左室射血分數（ LVEF）、遊離三碘甲狀腺原氨痠（ FT3）、遊離甲狀腺素（ FT4）和促甲狀腺素（ TSH）及治療3箇月內不良反應和竇性心律轉複情況。結果兩組患者治療前收縮壓、舒張壓、心率及LVEF比較，差異無統計學意義（P﹥0.05）；觀察組患者治療後收縮壓、舒張壓、心率均低于對照組，LVEF高于對照組（P﹤0.05）。兩組患者治療前FH3、FH4、TSH比較，差異無統計學意義（ P ﹥0.05）；觀察組患者治療後 FT3、FT4均低于對照組， TSH高于對照組（P﹤0.05）。兩組患者不良反應髮生率比較，差異無統計學意義（P﹥0.05）；觀察組患者竇性心律轉複率高于對照組（ P﹤0.05）。結論丙硫氧嘧啶聯閤大劑量普萘洛爾治療甲狀腺功能亢進癥閤併心房纖顫的臨床療效顯著，安全性較好。
목적：탐토병류양밀정연합불동제량보내락이치료갑상선공능항진증합병심방섬전적림상료효。방법선취2011년3월—2014년3월고안시인민의원내분비과수치적갑상선공능항진증합병심방섬전환자122례，채용수궤수자표법장소유환자분위관찰조화대조조，매조61례。량조환자균채용병류양밀정치료，관찰조연합대제량보내락이치료（30 mg/차，3차/d），대조조연합소제량보내락이치료（10 mg/차，3차/d）。비교량조환자치료전급치료8주후심솔、혈압、좌실사혈분수（ LVEF）、유리삼전갑상선원안산（ FT3）、유리갑상선소（ FT4）화촉갑상선소（ TSH）급치료3개월내불량반응화두성심률전복정황。결과량조환자치료전수축압、서장압、심솔급LVEF비교，차이무통계학의의（P﹥0.05）；관찰조환자치료후수축압、서장압、심솔균저우대조조，LVEF고우대조조（P﹤0.05）。량조환자치료전FH3、FH4、TSH비교，차이무통계학의의（ P ﹥0.05）；관찰조환자치료후 FT3、FT4균저우대조조， TSH고우대조조（P﹤0.05）。량조환자불량반응발생솔비교，차이무통계학의의（P﹥0.05）；관찰조환자두성심률전복솔고우대조조（ P﹤0.05）。결론병류양밀정연합대제량보내락이치료갑상선공능항진증합병심방섬전적림상료효현저，안전성교호。
Objective To investigate the clinical effect of propylthiouracil combined with different doses of propranolol on hyperthyroidism complicated with atrial fibrillation. Methods From March 2011 to March 2014, a total of 122 hyperthyroidism patients complicated with atrial fibrillation were selected in the People's Hospital of Gaoan, and they were divided into control group and observation group according to random number table,each of 61 cases. Patients of both groups were given propylthiouracil,and patients of observation group were given extra large dose of propranolol(30 mg per time,3 times per day),patients of control group were given extra small dose of propranolol(10 mg per time,3 times per day). HR,SBP, SDP,LVEF,FT3 ,FT4 ,TSH were compared between the two groups before and after treatment,incidence of adverse reactions and recovery rate of sinus rhythm were recorded during the 3-month treatment. Results No statistically significant differences of HR,SBP,SDP,LVEF,FT3,FT4,TSH was found between the two groups before treatment(P ﹥0. 05);HR,SBP, SDP,FT3 ,FT4 of observation group was lower than that of control group after treatment, respectively ( P ﹤0. 05 ), while LVEF,TSH of observation group was higher than that of control group after treatment,respectively(P﹤0. 05). No statistically significant differences of incidence of adverse reactions was found between the two groups ( P ﹥0. 05 ), while recovery rate of sinus rhythm of observation group was higher than that control group(P﹤0. 05). Conclusion Propylthiouracil combined with large dose of propranolol has remarkable clinical effect on hyperthyroidism complicated with atrial fibrillation,and is safe.
