实用心脑肺血管病杂志
實用心腦肺血管病雜誌
실용심뇌폐혈관병잡지
PRACTICAL JOURNAL OF CARDIAC CEREBRAL PNEUMAL AND VASCULAR DISEASE
2015年
4期
26-28
,共3页
卒中%大内皮素1%D-二聚体%脂蛋白-a%预测
卒中%大內皮素1%D-二聚體%脂蛋白-a%預測
졸중%대내피소1%D-이취체%지단백-a%예측
Stroke%Big endothelin-1%D-dimer%Lipoproteins( a)%Forecasting
目的:探究血浆大内皮素1(big ET-1)、D-二聚体及血清脂蛋白-a〔Lp(a)〕水平对急性缺血性脑卒中( AIS)的预测价值。方法选取重庆市北部新区第一人民医院2011年1月—2014年1月收治的AIS患者68例作为卒中组,再按不同梗死面积分为两亚组,即腔隙性组29例(梗死灶横断面最大径﹤1.5 cm)和非腔隙性组39例(梗死灶横断面最大径≥1.5 cm);选取同期在本院体检健康者68例为对照组。卒中组患者于入院次日、对照组受试者于体检当日清晨抽取空腹肘静脉血2 ml,离心后分别检测血浆big ET-1、D-二聚体水平、C反应蛋白( CRP)、纤维蛋白原(FIB)水平、活化部分凝血活酶时间(APTT)、凝血酶原时间(PT)、国际标准化比值(INR)、血清Lp(a)水平,并进行比较。结果卒中组患者血浆big ET-1、D-二聚体、CRP、FIB水平,血清Lp( a)水平均高于对照组,APTT长于对照组(P﹤0.05);两组受试者PT、INR比较,差异无统计学意义(P﹥0.05)。非腔隙性组患者血浆big ET-1、D-二聚体及血清Lp(a)水平高于腔隙性组(P﹤0.05)。结论血浆big ET-1、D-二聚体及血清Lp ( a)水平对AIS有一定的预测价值,可用于评估AIS患者梗死面积。
目的:探究血漿大內皮素1(big ET-1)、D-二聚體及血清脂蛋白-a〔Lp(a)〕水平對急性缺血性腦卒中( AIS)的預測價值。方法選取重慶市北部新區第一人民醫院2011年1月—2014年1月收治的AIS患者68例作為卒中組,再按不同梗死麵積分為兩亞組,即腔隙性組29例(梗死竈橫斷麵最大徑﹤1.5 cm)和非腔隙性組39例(梗死竈橫斷麵最大徑≥1.5 cm);選取同期在本院體檢健康者68例為對照組。卒中組患者于入院次日、對照組受試者于體檢噹日清晨抽取空腹肘靜脈血2 ml,離心後分彆檢測血漿big ET-1、D-二聚體水平、C反應蛋白( CRP)、纖維蛋白原(FIB)水平、活化部分凝血活酶時間(APTT)、凝血酶原時間(PT)、國際標準化比值(INR)、血清Lp(a)水平,併進行比較。結果卒中組患者血漿big ET-1、D-二聚體、CRP、FIB水平,血清Lp( a)水平均高于對照組,APTT長于對照組(P﹤0.05);兩組受試者PT、INR比較,差異無統計學意義(P﹥0.05)。非腔隙性組患者血漿big ET-1、D-二聚體及血清Lp(a)水平高于腔隙性組(P﹤0.05)。結論血漿big ET-1、D-二聚體及血清Lp ( a)水平對AIS有一定的預測價值,可用于評估AIS患者梗死麵積。
목적:탐구혈장대내피소1(big ET-1)、D-이취체급혈청지단백-a〔Lp(a)〕수평대급성결혈성뇌졸중( AIS)적예측개치。방법선취중경시북부신구제일인민의원2011년1월—2014년1월수치적AIS환자68례작위졸중조,재안불동경사면적분위량아조,즉강극성조29례(경사조횡단면최대경﹤1.5 cm)화비강극성조39례(경사조횡단면최대경≥1.5 cm);선취동기재본원체검건강자68례위대조조。졸중조환자우입원차일、대조조수시자우체검당일청신추취공복주정맥혈2 ml,리심후분별검측혈장big ET-1、D-이취체수평、C반응단백( CRP)、섬유단백원(FIB)수평、활화부분응혈활매시간(APTT)、응혈매원시간(PT)、국제표준화비치(INR)、혈청Lp(a)수평,병진행비교。결과졸중조환자혈장big ET-1、D-이취체、CRP、FIB수평,혈청Lp( a)수평균고우대조조,APTT장우대조조(P﹤0.05);량조수시자PT、INR비교,차이무통계학의의(P﹥0.05)。비강극성조환자혈장big ET-1、D-이취체급혈청Lp(a)수평고우강극성조(P﹤0.05)。결론혈장big ET-1、D-이취체급혈청Lp ( a)수평대AIS유일정적예측개치,가용우평고AIS환자경사면적。
Objective To investigate the predictive value of plasma big endothelin-1,D-dimer levels and serum lipoprotein( a) level on acute ischemic stroke. Methods A total of 68 patients with acute ischemic stroke were selected as case group in the First People's Hospital of Xinbei District of Chongqing from January 2011 to January 2014,and a total of 68 healthy cases were selected as control group at the same time. According to the infarction areas, patients of case group were divided into subgroups A ( with the maximum diameter of infarction areas ﹤1. 5 cm, n =29 ) and B ( with the maximum diameter of infarction areas≥1. 5 cm,n=39). Plasma big endothelin-1,D-dimer,CRP,FIB levels,serum lipoprotein (a)level,APTT,PT and INR were detected and compared. Results Plasma big endothelin -1,D -dimer,CRP,FIB levels and serum lipoprotein( a) level of case group were statistically significantly higher than those of control group,APTT of case group was statistically significantly longer than that of control group(P﹤0. 05);no statistically significant differences of PT or INR were found between the two groups(P﹥0. 05). Plasma big endothelin-1,D-dimer levels and serum lipoprotein(a) level of B subgroup were statistically significantly higher than those of A subgroup ( P ﹤0. 05 ). Conclusion Plasma big endothelin-1,D-dimmer levels and serum lipoprotein(a)level have some predictive value on acute ischemic stroke,can be used in evaluating the infarction areas.