实用心脑肺血管病杂志
實用心腦肺血管病雜誌
실용심뇌폐혈관병잡지
PRACTICAL JOURNAL OF CARDIAC CEREBRAL PNEUMAL AND VASCULAR DISEASE
2015年
4期
40-43
,共4页
刘波%宋铁友%宋卓%石寒冰%刘宏
劉波%宋鐵友%宋卓%石寒冰%劉宏
류파%송철우%송탁%석한빙%류굉
肺疾病,慢性阻塞性%一氧化氮%呼吸功能试验
肺疾病,慢性阻塞性%一氧化氮%呼吸功能試驗
폐질병,만성조새성%일양화담%호흡공능시험
Pulmonary disease,chronic obstructive%Nitric oxide%Respiratory function tests
目的：观察慢性阻塞性肺疾病（ COPD）患者呼出气一氧化氮（ FENO）浓度变化，并探讨其临床意义。方法选取齐齐哈尔医学院第三附属医院呼吸科2013年3月—2014年3月收治的住院COPD患者120例，根据2009年慢性阻塞性肺疾病全球创议（ GOLD）分为GOLDⅠ级组、GOLDⅡ级组、GOLDⅢ级组、GOLDⅣ级组，每组30例；选取同期在齐齐哈尔医学院第三附属医院体检健康者100例作为对照组。检测各组受试者肺功能及FENO浓度，计算第一秒用力呼气容积（ FEV1）/用力肺活量（ FVC），FEV1占预计值百分比。结果 GOLDⅠ级组、GOLDⅡ级组、GOLDⅢ级组、GOLDⅣ级组患者FEV1/FVC、FEV1占预计值百分比低于对照组，FENO浓度高于对照组，GOLDⅡ级组、GOLDⅢ级组、GOLDⅣ级组患者FEV1/FVC、FEV1占预计值百分比低于GOLDⅠ级组，FENO浓度高于GOLDⅠ级组，GOLDⅢ级组、GOLDⅣ级组患者FEV1/FVC、FEV1占预计值百分比低于GOLDⅡ级组，FENO浓度高于GOLDⅡ级组，GOLDⅣ级组患者FEV1/FVC、FEV1占预计值百分比低于GOLDⅢ级组，FENO浓度高于GOLDⅢ级组（P﹤0.05）；Spearman等级相关分析结果显示，FENO浓度与GOLD分级呈正相关（r=0.776，P﹤0.01）。结论 COPD患者FENO浓度明显升高，且FENO浓度与COPD严重程度密切相关，检测FENO浓度对判断COPD患者病情严重程度及预后具有重要意义。
目的：觀察慢性阻塞性肺疾病（ COPD）患者呼齣氣一氧化氮（ FENO）濃度變化，併探討其臨床意義。方法選取齊齊哈爾醫學院第三附屬醫院呼吸科2013年3月—2014年3月收治的住院COPD患者120例，根據2009年慢性阻塞性肺疾病全毬創議（ GOLD）分為GOLDⅠ級組、GOLDⅡ級組、GOLDⅢ級組、GOLDⅣ級組，每組30例；選取同期在齊齊哈爾醫學院第三附屬醫院體檢健康者100例作為對照組。檢測各組受試者肺功能及FENO濃度，計算第一秒用力呼氣容積（ FEV1）/用力肺活量（ FVC），FEV1佔預計值百分比。結果 GOLDⅠ級組、GOLDⅡ級組、GOLDⅢ級組、GOLDⅣ級組患者FEV1/FVC、FEV1佔預計值百分比低于對照組，FENO濃度高于對照組，GOLDⅡ級組、GOLDⅢ級組、GOLDⅣ級組患者FEV1/FVC、FEV1佔預計值百分比低于GOLDⅠ級組，FENO濃度高于GOLDⅠ級組，GOLDⅢ級組、GOLDⅣ級組患者FEV1/FVC、FEV1佔預計值百分比低于GOLDⅡ級組，FENO濃度高于GOLDⅡ級組，GOLDⅣ級組患者FEV1/FVC、FEV1佔預計值百分比低于GOLDⅢ級組，FENO濃度高于GOLDⅢ級組（P﹤0.05）；Spearman等級相關分析結果顯示，FENO濃度與GOLD分級呈正相關（r=0.776，P﹤0.01）。結論 COPD患者FENO濃度明顯升高，且FENO濃度與COPD嚴重程度密切相關，檢測FENO濃度對判斷COPD患者病情嚴重程度及預後具有重要意義。
목적：관찰만성조새성폐질병（ COPD）환자호출기일양화담（ FENO）농도변화，병탐토기림상의의。방법선취제제합이의학원제삼부속의원호흡과2013년3월—2014년3월수치적주원COPD환자120례，근거2009년만성조새성폐질병전구창의（ GOLD）분위GOLDⅠ급조、GOLDⅡ급조、GOLDⅢ급조、GOLDⅣ급조，매조30례；선취동기재제제합이의학원제삼부속의원체검건강자100례작위대조조。검측각조수시자폐공능급FENO농도，계산제일초용력호기용적（ FEV1）/용력폐활량（ FVC），FEV1점예계치백분비。결과 GOLDⅠ급조、GOLDⅡ급조、GOLDⅢ급조、GOLDⅣ급조환자FEV1/FVC、FEV1점예계치백분비저우대조조，FENO농도고우대조조，GOLDⅡ급조、GOLDⅢ급조、GOLDⅣ급조환자FEV1/FVC、FEV1점예계치백분비저우GOLDⅠ급조，FENO농도고우GOLDⅠ급조，GOLDⅢ급조、GOLDⅣ급조환자FEV1/FVC、FEV1점예계치백분비저우GOLDⅡ급조，FENO농도고우GOLDⅡ급조，GOLDⅣ급조환자FEV1/FVC、FEV1점예계치백분비저우GOLDⅢ급조，FENO농도고우GOLDⅢ급조（P﹤0.05）；Spearman등급상관분석결과현시，FENO농도여GOLD분급정정상관（r=0.776，P﹤0.01）。결론 COPD환자FENO농도명현승고，차FENO농도여COPD엄중정도밀절상관，검측FENO농도대판단COPD환자병정엄중정도급예후구유중요의의。
Objective To observe the changes of fraction of exhaled nitric oxide ( FENO ) in patients with chronic obstructive pulmonary disease( COPD),to explore its clinical significance. Methods From March 2013 to March 2014,a total of 120 inpatients with COPD were selected in the Department of Respiratory, the Third Affiliated Hospital of Qiqihaer Medical College,and they were divided into groups A( GOLD grade at Ⅰ),B( GOLD grade at Ⅱ),C( GOLD grade atⅢ),D(GOLD grade atⅣ)according to Chronic Obstructive Pulmonary Disease Global Initiatives(GOLD)in 2009,each of 30 cases;a total of 100 healthy cases were selected as control group. Lung function and FENO were detected,FEV1/FVC and FEV1 pre% were calculated. Results FEV1/FVC and FEV1 pre% of groups A, B, C, D were lower than those of control group,respectively,while FENO was higher than that of control group,respectively(P﹤0. 05);FEV1/FVC and FEV1pre%of groups B,C,D were lower than those of group A,respectively,while FENO was higher than that of group A,respectively (P﹤0. 05);FEV1/FVC and FEV1pre% of groups C,D were lower than those of group B,respectively,while FENO was higher than that of group B,respectively(P﹤0. 05);FEV1/FVC and FEV1pre% of group D were lower than those of group C, while FENO was higher than that of group C ( P ﹤0. 05 ). Spearman ranked correlation analysis showed that, FENO was positively correlated with GOLD grade(r =0. 776,P ﹤0. 01). Conclusion FENO is obviously elevated in patients with COPD,and it is positively correlated with the severity of COPD,the detection of FENO is with important clinical significance to judge the severity and prognosis of COPD.
