CAJ | 학술논문

整合因子复合体（ integrator complex ）是一个新近发现的多功能蛋白质复合物，由至少12个进化上保守的亚基（ integrator complex subunits ， INTS1～INTS12）组成。该复合体能与RNA聚合酶Ⅱ（ RNAPⅡ）大亚基的具有重复氨基酸序列的C端相互作用，进而介导小核RNA（small nuclear RNA， snRNA）U1／U2的3′端加工。整合因子复合体还能通过与RNAPⅡ、延伸负调控因子NELF和转录延伸因子Spt5发生相互作用，调控NELF介导的RNAPⅡ的暂停－释放，进而调控mRNA的合成。近年来，有研究陆续报道整合因子复合体还在DNA损伤应答、核周动力蛋白的募集、细胞核内卡哈尔体（ Cajal body ）的完整性、脂肪细胞的分化成熟、造血、初级纤毛的形成、肿瘤的发生发展和病毒微小RNA（ microRNA，miRNA）形成等方面发挥重要作用。该文综述了整合因子复合体的研究进展。
정합인자복합체（ integrator complex ）시일개신근발현적다공능단백질복합물，유지소12개진화상보수적아기（ integrator complex subunits ， INTS1～INTS12）조성。해복합체능여RNA취합매Ⅱ（ RNAPⅡ）대아기적구유중복안기산서렬적C단상호작용，진이개도소핵RNA（small nuclear RNA， snRNA）U1／U2적3′단가공。정합인자복합체환능통과여RNAPⅡ、연신부조공인자NELF화전록연신인자Spt5발생상호작용，조공NELF개도적RNAPⅡ적잠정－석방，진이조공mRNA적합성。근년래，유연구륙속보도정합인자복합체환재DNA손상응답、핵주동력단백적모집、세포핵내잡합이체（ Cajal body ）적완정성、지방세포적분화성숙、조혈、초급섬모적형성、종류적발생발전화병독미소RNA（ microRNA，miRNA）형성등방면발휘중요작용。해문종술료정합인자복합체적연구진전。
The integrator complex is multifunctional and contains at least 12 evolutionarily conserved subunits in hu-mans.It interacts with the C-terminal tail of the largest subunit of RNA-polymeraseⅡ ( RNAPⅡ) to promote 3′-end pro-cessing of small nuclear RNA (snRNA) U1/U2.It also interacts with RNAPⅡ, NELF and Spt5 to regulate NELF-mediated RNAPⅡpause/release and processivity at coding genes .Recently, the integrator complex is also reported to be involved in DNA damage response , dynein recruitment to the nuclear envelope , integrity of Cajal bodies , adipose differentiation , hem-atopoiesis , ciliogenesis , tumorigenesis and generation of viral microRNAs .This review discusses related research progress in the integrator complex .