中国免疫学杂志
中國免疫學雜誌
중국면역학잡지
CHINESE JOURNAL OF IMMUNOLOGY
2015年
5期
686-689
,共4页
IgG4相关性疾病%桥本甲状腺炎%临床特点%自身免疫疾病
IgG4相關性疾病%橋本甲狀腺炎%臨床特點%自身免疫疾病
IgG4상관성질병%교본갑상선염%림상특점%자신면역질병
IgG4-related disease%Hashimoto′s thyroiditis%Clinical characteristics%Auto-immune disease
目的：探讨IgG4相关性桥本甲状腺炎（ HT）患者血清IgG4水平及其临床意义。方法：酶联免疫吸附法测定129例HT患者血清IgG4水平，并根据IgG4水平将患者分为IgG4组（IgG4≥135 mg／dl）和非IgG4组（IgG4＜135 mg／dl）；电化学发光法测定血清甲状腺激素、甲状腺过氧化物酶抗体（ TPOAb）、甲状腺球蛋白抗体（ TgAb）；甲状腺超声影像检查。结果：HT患者血清TPOAb与同时测定的IgG4水平（r＝0.4371，P＝0.0127）和IgG4／IgG比值（r＝0.3962，P＝0.0235）呈显著正相关。与非IgG4组（97例）比较，IgG4组（32例）：①平均患病年龄趋年轻化（P＝0.0293）；②较高的血清TPOAb（P＝0.0021）、TgAb（P＝0.0128）水平；③超声影像：更易形成甲状腺结节（P＝0.0226）；④多因素Logistic回归分析结果提示，血清IgG4、TPOAb水平是患甲状腺结节危险因素，OR值分别为1.672（P＝0.021）、2.549（P＝0.014）。结论：IgG4相关性HT患者存在相应的临床特征。对于血清中IgG4水平明显升高的HT患者，应更加密切监测甲状腺功能及形态变化。
目的：探討IgG4相關性橋本甲狀腺炎（ HT）患者血清IgG4水平及其臨床意義。方法：酶聯免疫吸附法測定129例HT患者血清IgG4水平，併根據IgG4水平將患者分為IgG4組（IgG4≥135 mg／dl）和非IgG4組（IgG4＜135 mg／dl）；電化學髮光法測定血清甲狀腺激素、甲狀腺過氧化物酶抗體（ TPOAb）、甲狀腺毬蛋白抗體（ TgAb）；甲狀腺超聲影像檢查。結果：HT患者血清TPOAb與同時測定的IgG4水平（r＝0.4371，P＝0.0127）和IgG4／IgG比值（r＝0.3962，P＝0.0235）呈顯著正相關。與非IgG4組（97例）比較，IgG4組（32例）：①平均患病年齡趨年輕化（P＝0.0293）；②較高的血清TPOAb（P＝0.0021）、TgAb（P＝0.0128）水平；③超聲影像：更易形成甲狀腺結節（P＝0.0226）；④多因素Logistic迴歸分析結果提示，血清IgG4、TPOAb水平是患甲狀腺結節危險因素，OR值分彆為1.672（P＝0.021）、2.549（P＝0.014）。結論：IgG4相關性HT患者存在相應的臨床特徵。對于血清中IgG4水平明顯升高的HT患者，應更加密切鑑測甲狀腺功能及形態變化。
목적：탐토IgG4상관성교본갑상선염（ HT）환자혈청IgG4수평급기림상의의。방법：매련면역흡부법측정129례HT환자혈청IgG4수평，병근거IgG4수평장환자분위IgG4조（IgG4≥135 mg／dl）화비IgG4조（IgG4＜135 mg／dl）；전화학발광법측정혈청갑상선격소、갑상선과양화물매항체（ TPOAb）、갑상선구단백항체（ TgAb）；갑상선초성영상검사。결과：HT환자혈청TPOAb여동시측정적IgG4수평（r＝0.4371，P＝0.0127）화IgG4／IgG비치（r＝0.3962，P＝0.0235）정현저정상관。여비IgG4조（97례）비교，IgG4조（32례）：①평균환병년령추년경화（P＝0.0293）；②교고적혈청TPOAb（P＝0.0021）、TgAb（P＝0.0128）수평；③초성영상：경역형성갑상선결절（P＝0.0226）；④다인소Logistic회귀분석결과제시，혈청IgG4、TPOAb수평시환갑상선결절위험인소，OR치분별위1.672（P＝0.021）、2.549（P＝0.014）。결론：IgG4상관성HT환자존재상응적림상특정。대우혈청중IgG4수평명현승고적HT환자，응경가밀절감측갑상선공능급형태변화。
Objective:To explore the serum IgG4 level in patients with IgG4-related Hashimoto thyroiditis(IgG4 HT),and its clinical implications.Methods:The serum IgG4 was determined in 129 patients with HT using enzyme-linked immunosorbent assays and classified into two subgroups based on IgG4 level:IgG4 HT group(IgG4≥135 mg/dl)and non-IgG4 HT group(IgG4<135 mg/dl).And the levels of serum thyroid hormone and thyroid peroxidase antibodies(TPOAb)and thyroglobulin antibodies(TgAb)were measured by electro-chemiluminescence immunoassay.Ultrasonic imaging of the thyroid gland were detected.Results:The TPOAb levels correlated significantly with both serum IgG4 levels(r=0.437 1,P=0.012 7)and IgG4/IgG ratios(r=0.396 2,P=0.023 5)in the patients with HT.Compared with that of non-IgG4 HT group(n=97),IgG4 HT group(n=32):①The mean age was lower(P=0.029 3);②Higher levels of serum TPOAb(P=0.002 1)and TgAb(P=0.012 8);③Ultrasound imaging:the more obvious thyroid nodule(P=0.022 6);④Logistic regression analysis showed that serum IgG4 and TPOAb were the risk factor for thyroid nodules(OR=1.672,P=0.021;2.549,P=0.014 ).Conclusion: IgG4 HT patients existed corresponding clinical characteristics.For the HT-patients with elevated serum IgG4,thyroid function and morphology should were more closely monitored.
