CAJ | 학술논문

目的：分析对比结直肠癌腹腔镜与开腹手术对免疫功能的影响。方法：选取我科2010年1月至2013年12月因结直肠癌入院行手术治疗的患者共85例，随机分为实验组和对照组。实验组行腹腔镜手术，对照组行开腹手术。对比两组患者术前及术后1 d、7 d的外周血淋巴细胞各亚群变化、免疫球蛋白、CRP和IL-6水平、NO和活性氧物质（ Reactive oxygen species，ROS）水平。结果：两组患者术后1 d、7 d的CD3、CD4、CD4／CD8水平显著低于术前，CD8显著高于术前，P＜0.05；实验组术后1 d、7 d的CD3、CD4、CD4／CD8水平显著高于对照组，CD8显著低于对照组，P＜0.05。两组患者术后1 d、7 d的IL-6、CRP水平显著高于术前，IgG、IgM和IgA显著低于术前，P＜0.05；实验组术后1 d、7 d的IL-6、CRP水平显著低于对照组，IgG、IgM和IgA显著高于对照组，P＜0.05。对照组术后1 d、7 d的NO和ROS水平显著高于术前和实验组术后同期，P＜0.05；实验组术后1 d、7 d的NO和ROS水平与术前无显著差异，P＞0.05。结论：腹腔镜治疗结直肠癌和开腹手术相比，对于人体免疫功能影响更小，具有一定的保护作用。
목적：분석대비결직장암복강경여개복수술대면역공능적영향。방법：선취아과2010년1월지2013년12월인결직장암입원행수술치료적환자공85례，수궤분위실험조화대조조。실험조행복강경수술，대조조행개복수술。대비량조환자술전급술후1 d、7 d적외주혈림파세포각아군변화、면역구단백、CRP화IL-6수평、NO화활성양물질（ Reactive oxygen species，ROS）수평。결과：량조환자술후1 d、7 d적CD3、CD4、CD4／CD8수평현저저우술전，CD8현저고우술전，P＜0.05；실험조술후1 d、7 d적CD3、CD4、CD4／CD8수평현저고우대조조，CD8현저저우대조조，P＜0.05。량조환자술후1 d、7 d적IL-6、CRP수평현저고우술전，IgG、IgM화IgA현저저우술전，P＜0.05；실험조술후1 d、7 d적IL-6、CRP수평현저저우대조조，IgG、IgM화IgA현저고우대조조，P＜0.05。대조조술후1 d、7 d적NO화ROS수평현저고우술전화실험조술후동기，P＜0.05；실험조술후1 d、7 d적NO화ROS수평여술전무현저차이，P＞0.05。결론：복강경치료결직장암화개복수술상비，대우인체면역공능영향경소，구유일정적보호작용。
Objective:To analyze the impact of colorectal cancer laparoscopic and open surgery on immune function.Methods:85 patients from January 2010 to December 2013 due to surgical treatment of colorectal cancer hospitalized in our department were randomly divided into experimental and control groups.The experimental group underwent laparoscopic surgery, the control group underwent laparotomy.The peripheral blood lymphocyte subsets, immunoglobulins, CRP and IL-6 levels, NO and ROS levels were compared in two groups of patients before and after one day,seven days of surgery.Results: The postoperative CD3,CD4,CD4/CD8 level after one day and seven days of surgery was significantly lower than before surgery, CD8 was significantly higher than before surgery,P<0.05.The postoperative CD3, CD4, CD4/CD8 level after one day and seven days in the experimental group were significantly higher,CD8 was significantly lower than the control group,P<0.05.The postoperative IL-6,CRP levels after one day and seven days of surgery were significantly higher than before surgery,IgG,IgM and IgA were significantly lower than before surgery,P<0.05.The postoperative IL-6,CRP levels after one day and seven days of surgery in the experimental group were significantly lower than the control group,IgG,IgM and IgA were significantly higher,P<0.05.The NO and ROS levels after one day and seven days of surgery in the control group were significantly higher than the preoperative and postoperative period the experimental group,P<0.05.The NO and ROS levels after one day and seven days of surgery in the experimental group were no significant difference,P>0.05.Conclusion:Compared to open surgery,laparoscopic treatment of colorectal cancer has a protective and smaller effect for the body′s immune func-tion.