CAJ | 학술논문

目的探讨奥扎格雷钠联合盐酸小檗碱治疗急性脑梗死疗效及其对糖脂代谢的影响.方法将158例脑梗死急性期患者按数字表法随机分为使用奥扎格雷钠对照组和联合应用奥扎格雷钠与盐酸小檗碱观察组,在治疗前和治疗2周后按照中国脑卒中临床神经功能缺失评分量表及美国国立卫生研究院卒中量表(NIHSS)测试其神经功能缺失情况,评价临床神经功能情况;治疗后1、3、6个月测其日常生活活动能力量表,评价联合用药远期恢复情况.采用浊度法测定各组糖脂指标水平的变化.结果治疗2周后观察组总有效率为87.01％,明显高于对照组的69.14％(x2=7.316,P＜0.01).观察组患者中国脑卒中临床神经功能缺失评分量表和NIHSS评分均明显优于对照组(=3.207、1.274,均P＜0.叭).两组治疗后1个月、3个月和6个月后患者日常生活能力与治疗前比较均明显改善(t =7.266和t=8.850、t=1.429和扛2.816、=9.218和t =6.739,均P＜0.01),治疗3个月和6个月观察组患者日常生活能力优于对照组(t=1.163、t=0.932,均P＜0.01),两组治疗后6个月与治疗后3个月比较日常生活能力差异均无统计学意义(t=7.861、t =5.005,均P＞0.05).治疗后观察组空腹血糖值显著下降(t=0.859,P＜0.01),血清总胆固醇、甘油三酯及低密度脂蛋白水平均显著下降(t =0.257、=0.114和t=0.378,均P＜0.01),高密度脂蛋白水平虽略有升高,但差异无统计学意义(t=1.960,P＞0.05).结论奥扎格雷钠联合盐酸小檗碱治疗急性脑梗死疗效显著,可明显降低患者糖脂代谢水平.
목적 탐토오찰격뢰납연합염산소벽감치료급성뇌경사료효급기대당지대사적영향.방법 장158례뇌경사급성기환자안수자표법수궤분위사용오찰격뢰납대조조화연합응용오찰격뢰납여염산소벽감관찰조,재치료전화치료2주후안조중국뇌졸중림상신경공능결실평분량표급미국국립위생연구원졸중량표(NIHSS)측시기신경공능결실정황,평개림상신경공능정황;치료후1、3、6개월측기일상생활활동능역량표,평개연합용약원기회복정황.채용탁도법측정각조당지지표수평적변화.결과 치료2주후관찰조총유효솔위87.01％,명현고우대조조적69.14％(x2=7.316,P＜0.01).관찰조환자중국뇌졸중림상신경공능결실평분량표화NIHSS평분균명현우우대조조(=3.207、1.274,균P＜0.팔).량조치료후1개월、3개월화6개월후환자일상생활능력여치료전비교균명현개선(t =7.266화t=8.850、t=1.429화강2.816、=9.218화t =6.739,균P＜0.01),치료3개월화6개월관찰조환자일상생활능력우우대조조(t=1.163、t=0.932,균P＜0.01),량조치료후6개월여치료후3개월비교일상생활능력차이균무통계학의의(t=7.861、t =5.005,균P＞0.05).치료후관찰조공복혈당치현저하강(t=0.859,P＜0.01),혈청총담고순、감유삼지급저밀도지단백수평균현저하강(t =0.257、=0.114화t=0.378,균P＜0.01),고밀도지단백수평수략유승고,단차이무통계학의의(t=1.960,P＞0.05).결론 오찰격뢰납연합염산소벽감치료급성뇌경사료효현저,가명현강저환자당지대사수평.
Objective To investigate the effects of sodium ozagrel and berberine hydrochloride in the treatment of acute cerebral infarction and its effect on glucose and lipid metabolism.Methods According to the digital table,158 patients with acute cerebral infarction were randomly divided into the two groups:the control group was treated with the sodium ozagrel group and the observation group was treated combined with sodium ozagrel and berberine hydrochloride.After 2 weeks,Chinese stroke clinical neural function defect score scale and the National Institutes of Health Stroke Scale (NIHSS) was used to evaluate neurological function.The therapeutic effectiveness was assessed by ADL after treatment 1,3,6 months.The changes of glucose and lipid levels were detected by turbidimetric method.Results The total effective ratein the observation group was obviously higher than that of the control group (87.01％ vs 69.14％) (x2 =7.316,P ＜0.01).Of the above two ways of nerve function score indicateed that the observation group was significantly better than that of the control group (t =3.207,1.274,all P ＜ 0.01).ADL score of all patients was significantly better than that of before treatment with drug in the two groups after 1 month,3 months and 6 months (t =7.266 and t =8.850,t =1.429 and t =2.816,t =9.218 and t =6.739,P ＜0.01).Compared with the control group,ADL score of the observation group was significantly improved after 3 months and 6 months (t =1.163,0.932,all P ＜0.01).The significant difference was found between the control group and the observation group after 3 months and 6 months (t =7.861,5.005,all P ＞ 0.05).After the treatment,the fasting blood glucose level was reduced significantly in the observation group (t =0.859,P ＜ 0.01),total cholesteroland high-density lipoprotein,triglyceride,low density lipoprotein level were significantly decreased (t =0.257,0.114,0.378,all P ＜ 0.01),but there was no significant difference in HDL-C level (t =1.960,P ＞ 0.05).Conclusion The therapeutic effect of berberine hydrochloride combined with sodium ozagrel is better in the treatment of acute cerebral infarction,and the level of glucose and lipid metabolism was significantly decreased.