CAJ | 학술논문

自然杀伤细胞（ Natural killer cells，NK细胞）是天然免疫应答中关键的效应细胞，通过分泌细胞因子和细胞杀伤功能发挥病原体清除和肿瘤免疫监视的作用。造血干细胞在外在因子和内在因子的调控下，可定向分化为NK细胞。经过30年的研究，科学家们在NK细胞发育过程、发育微环境、发育调控及NK细胞与疾病关系等基础和应用研究方面取得了长足进步。在本综述中，我们将详细探讨调控NK细胞发育的分子机制及NK细胞功能低下与疾病的关系。
자연살상세포（ Natural killer cells，NK세포）시천연면역응답중관건적효응세포，통과분비세포인자화세포살상공능발휘병원체청제화종류면역감시적작용。조혈간세포재외재인자화내재인자적조공하，가정향분화위NK세포。경과30년적연구，과학가문재NK세포발육과정、발육미배경、발육조공급NK세포여질병관계등기출화응용연구방면취득료장족진보。재본종술중，아문장상세탐토조공NK세포발육적분자궤제급NK세포공능저하여질병적관계。
Natural killer cells are the key effector cells in innate immune response,playing the role in pathogen clearance and tumor immunosurveillance by cytokine secretion and cytotoxicity.Hematopoietic stem cells go through developmental intermediates to generate mature NK cells under the progressive regulation of extrinsic factors and intrinsic factors.In the past thirty years, great progresses have been made in the developmental progress,niches,regulation of NK cells and the relationship between NK cells and dis-eases.In this review,we will discuss in detail the molecular mechanisms of NK cell development and the diseases caused by functional compromise of NK cells.