中国基层医药
中國基層醫藥
중국기층의약
CHINESE JOURNAL OF PRIMARY MEDICINE AND PHARMACY
2015年
9期
1300-1302
,共3页
催乳素瘤%基质金属蛋白酶9%血管内皮生长因子类
催乳素瘤%基質金屬蛋白酶9%血管內皮生長因子類
최유소류%기질금속단백매9%혈관내피생장인자류
Prolactinoma%Matrix metalloproteinase 9%Vascular endothelial growth factors
目的 探讨侵袭性垂体腺瘤患者临床特征与基质金属蛋白酶9(MMP-9)、血管内皮生长因子(VEGF)表达水平的关系.方法 选取96例垂体腺瘤患者为研究对象,46例侵袭性垂体腺瘤,50例非侵袭性垂体腺瘤,免疫组化法测定瘤组织中MMP-9、VEGF表达水平,分析其与肿瘤侵袭性的相关性.结果 侵袭性垂体腺瘤组织中MMP-9、VEGF强阳性表达率为54.35％、52.17％,总阳性表达率为89.13％、95.65％,显著高于非侵袭性垂体腺瘤组织中MMP-9、VEGF强阳性表达率的16.00％、20.00％,总阳性表达率的44.00％、56.00％(x2=15.618、9.416、21.631、20.090,均P＜0.05);MMP-9、VEGF为阳性情况下侵袭性垂体腺瘤体积、最大径显著高于非侵袭性组(t =4.32、3.67、2.49、2.54,均P＜0.05),MMP-9、VEGF为阴性情况下侵袭性垂体腺瘤与非侵袭性组差异均无统计学意义(t=1.56、1.47、0.53、0.21,均P＞0.05);经相关性分析,侵袭性垂体腺瘤患者MMP二9与VEGF表达水平呈正相关(r=0.734,P＜0.01).结论 侵袭性垂体腺瘤组织中MMP-9与VEGF表达增高,MMP-9与VEGF可作为辅助垂体腺瘤侵袭性判断的生物学指标.
目的 探討侵襲性垂體腺瘤患者臨床特徵與基質金屬蛋白酶9(MMP-9)、血管內皮生長因子(VEGF)錶達水平的關繫.方法 選取96例垂體腺瘤患者為研究對象,46例侵襲性垂體腺瘤,50例非侵襲性垂體腺瘤,免疫組化法測定瘤組織中MMP-9、VEGF錶達水平,分析其與腫瘤侵襲性的相關性.結果 侵襲性垂體腺瘤組織中MMP-9、VEGF彊暘性錶達率為54.35％、52.17％,總暘性錶達率為89.13％、95.65％,顯著高于非侵襲性垂體腺瘤組織中MMP-9、VEGF彊暘性錶達率的16.00％、20.00％,總暘性錶達率的44.00％、56.00％(x2=15.618、9.416、21.631、20.090,均P＜0.05);MMP-9、VEGF為暘性情況下侵襲性垂體腺瘤體積、最大徑顯著高于非侵襲性組(t =4.32、3.67、2.49、2.54,均P＜0.05),MMP-9、VEGF為陰性情況下侵襲性垂體腺瘤與非侵襲性組差異均無統計學意義(t=1.56、1.47、0.53、0.21,均P＞0.05);經相關性分析,侵襲性垂體腺瘤患者MMP二9與VEGF錶達水平呈正相關(r=0.734,P＜0.01).結論 侵襲性垂體腺瘤組織中MMP-9與VEGF錶達增高,MMP-9與VEGF可作為輔助垂體腺瘤侵襲性判斷的生物學指標.
목적 탐토침습성수체선류환자림상특정여기질금속단백매9(MMP-9)、혈관내피생장인자(VEGF)표체수평적관계.방법 선취96례수체선류환자위연구대상,46례침습성수체선류,50례비침습성수체선류,면역조화법측정류조직중MMP-9、VEGF표체수평,분석기여종류침습성적상관성.결과 침습성수체선류조직중MMP-9、VEGF강양성표체솔위54.35％、52.17％,총양성표체솔위89.13％、95.65％,현저고우비침습성수체선류조직중MMP-9、VEGF강양성표체솔적16.00％、20.00％,총양성표체솔적44.00％、56.00％(x2=15.618、9.416、21.631、20.090,균P＜0.05);MMP-9、VEGF위양성정황하침습성수체선류체적、최대경현저고우비침습성조(t =4.32、3.67、2.49、2.54,균P＜0.05),MMP-9、VEGF위음성정황하침습성수체선류여비침습성조차이균무통계학의의(t=1.56、1.47、0.53、0.21,균P＞0.05);경상관성분석,침습성수체선류환자MMP이9여VEGF표체수평정정상관(r=0.734,P＜0.01).결론 침습성수체선류조직중MMP-9여VEGF표체증고,MMP-9여VEGF가작위보조수체선류침습성판단적생물학지표.
Objective To investigate the relationship in clinical features of invasive pituitary adenoma patients and their aggressive,matrix metalloproteinase 9 (MMP-9),vascular endothelial growth factor (VEGF) expression and tumor invasiveness of pituitary adenomas.Methods 96 patients with pituitary adenoma were selected,46 cases of invasive pituitary adenomas,50 cases of non-invasive pituitary adenomas,MMP-9,VEGF expression were detected by immunohistochemical assay,their expression levels were analyzed with tumor invasiveness correlation.Results MMP-9,VEGF expression in invasive pituitary adenomas strongly positive rates were 54.35％,52.17％,the total positive rates were 89.13％,95.65％,which were significantly higher than the non-invasive pituitary adenomas MMP-9,VEGF strong positive expression rate of 16.00％,20.00％,the total positive rates were 44.00％,56.00％ (x2 =15.618,9.416,21.631,20.090,all P ＜ 0.05);MMP-9,VEGF for invasive pituitary volume under positive circumstances,the maximum diameter was significantly higher than non-invasive of the group (t =4.32,3.67,2.49,2.54,all P ＜ 0.05),and MMP-9,VEGF were under negative circumstances invasive and non-invasive pituitary adenoma group,the difference was not statistically significant(t =1.56,1.47,0.53,0.21,all P ＞ 0.05);By correlation analysis,invasive pituitary adenoma MMP-9 expression was positively correlated with VEGF levels (r =0.734,P ＜ 0.01).Conclusion Invasive pituitary adenomas of MMP-9 and VEGF expression increased,MMP-9 and VEGF can be used as auxiliary judge biological indicators of invasive pituitary adenomas.
