CAJ | 학술논문

目的探讨叶酸干预对H型老年高血压患者血浆同型半胱氨酸(Hcy)水平和主要心血管事件的影响.方法选择200例H型老年高血压患者,按照数字表法随机分为观察组与对照组各100例,对照组给予健康教育及常规降压药治疗,观察组在常规治疗的基础上再给予叶酸治疗.比较两组患者治疗3个月后Hcy水平及3年内主要心血管事件发生率.结果 (1)观察组治疗后血浆Hcy水平明显降低,与治疗前比较差异有统计学意义(t=12.32,P＜0.05),对照组治疗后较治疗前无明显变化,两组治疗后血浆Hcy水平差异有统计学意义(t=11.45,P＞0.05).(2)观察组治疗后3年内心血管事件共发生6例,发生率为6％;对照组发生15例,发生率为15％,两组心血管事件发生率差异有统计学意义(x2=8.24,P＜0.05).结论叶酸干预可降低H型老年高血压患者血浆Hcy水平,控制心血管事件的发生.
목적 탐토협산간예대H형노년고혈압환자혈장동형반광안산(Hcy)수평화주요심혈관사건적영향.방법 선택200례H형노년고혈압환자,안조수자표법수궤분위관찰조여대조조각100례,대조조급여건강교육급상규강압약치료,관찰조재상규치료적기출상재급여협산치료.비교량조환자치료3개월후Hcy수평급3년내주요심혈관사건발생솔.결과 (1)관찰조치료후혈장Hcy수평명현강저,여치료전비교차이유통계학의의(t=12.32,P＜0.05),대조조치료후교치료전무명현변화,량조치료후혈장Hcy수평차이유통계학의의(t=11.45,P＞0.05).(2)관찰조치료후3년내심혈관사건공발생6례,발생솔위6％;대조조발생15례,발생솔위15％,량조심혈관사건발생솔차이유통계학의의(x2=8.24,P＜0.05).결론 협산간예가강저H형노년고혈압환자혈장Hcy수평,공제심혈관사건적발생.
Objective To investigate the effect of folic acid on plasma homocysteine(Hcy) levels and major cardiovascular events in elderly patients with H hypertension.Methods 200 elderly patients with H hypertension were randomly divided into the observation group and control group with 100 cases in each group according to the digital list methods,the control group was given health education and routine anti-hypertensive drug for treatment while the observation group was given folic acid on basis of the conventional treatment,the Hcy levels after 3 months of treatment and incidence of major cardiovascular events among 3 years of the two groups were compared.Results (1) The level of plasma Hcy in the observation group decreased significantly after treatment,with statistically significant difference when compared with before treatment (t =12.32,P ＜ 0.05),that in the control group had no obvious change after treatment than before treatment,there was statistically significant difference between the two groups after treatment(t =11.45,P ＞ 0.05);(2) The occurrence of cardiovascular events among 3 year after treatment of the observation group was 6 cases,the incidence rate was 6％,the control group occurred 15 cases,the incidence rate was 15％,the difference in the incidence of the two groups was statistically significant(x2 =8.24,P ＜ 0.05).Conclusion Folic acid intervention can reduce the plasma Hcy levels in elderly patients with H hypertension and control the occurrence of cardiovascular events.