中国基层医药
中國基層醫藥
중국기층의약
CHINESE JOURNAL OF PRIMARY MEDICINE AND PHARMACY
2015年
9期
1329-1332
,共4页
脑梗塞%阿斯匹林%氯吡格雷
腦梗塞%阿斯匹林%氯吡格雷
뇌경새%아사필림%록필격뢰
Cerebral Infarction%Aspirin%Clopidogrel Bisulfate
目的 探讨阿斯匹林联合氯吡格雷治疗急性脑梗死的临床疗效.方法 用随机数字表法将486例急性脑梗死患者分为两组,每组243例,对照组予常规药物和阿斯匹林治疗,治疗组在对照组治疗基础上加用氯吡格雷口服,均监测各系统出血发生情况,同时行凝血指标(TT、PT、APTT、FIB)监测.依据美国国立卫生研究院卒中量表(NIHSS)进行神经功能缺损的治疗前及治疗后评分.结果 两组治疗后NIHSS评分降低,治疗组治疗前[(15.04±2.53)分]与治疗后[(6.38±1.19)分]差异有统计学意义(P＜0.05);对照组治疗前[(16.26±2.71)分]与治疗后[(9.45±3.27)分]差异有统计学意义(P＜0.05).治疗组治疗后NIHSS评分[(6.38±1.19)分]与对照组[(9.45±3.27)分]比较,差异有统计学意义(t=8.264,P＜0.05).治疗组总有效率为94.24％,高于对照组的81.48％,差异有统计学意义(x2=11.485,P＜0.05).两组患者均未出现明确的出血反应.两组治疗后凝血指标在相对安全范围内延长,差异均无统计学意义(均P＞0.05).结论 阿斯匹林联合氯吡格雷对急性脑梗死患者是安全有效的抗血小板治疗方案.
目的 探討阿斯匹林聯閤氯吡格雷治療急性腦梗死的臨床療效.方法 用隨機數字錶法將486例急性腦梗死患者分為兩組,每組243例,對照組予常規藥物和阿斯匹林治療,治療組在對照組治療基礎上加用氯吡格雷口服,均鑑測各繫統齣血髮生情況,同時行凝血指標(TT、PT、APTT、FIB)鑑測.依據美國國立衛生研究院卒中量錶(NIHSS)進行神經功能缺損的治療前及治療後評分.結果 兩組治療後NIHSS評分降低,治療組治療前[(15.04±2.53)分]與治療後[(6.38±1.19)分]差異有統計學意義(P＜0.05);對照組治療前[(16.26±2.71)分]與治療後[(9.45±3.27)分]差異有統計學意義(P＜0.05).治療組治療後NIHSS評分[(6.38±1.19)分]與對照組[(9.45±3.27)分]比較,差異有統計學意義(t=8.264,P＜0.05).治療組總有效率為94.24％,高于對照組的81.48％,差異有統計學意義(x2=11.485,P＜0.05).兩組患者均未齣現明確的齣血反應.兩組治療後凝血指標在相對安全範圍內延長,差異均無統計學意義(均P＞0.05).結論 阿斯匹林聯閤氯吡格雷對急性腦梗死患者是安全有效的抗血小闆治療方案.
목적 탐토아사필림연합록필격뢰치료급성뇌경사적림상료효.방법 용수궤수자표법장486례급성뇌경사환자분위량조,매조243례,대조조여상규약물화아사필림치료,치료조재대조조치료기출상가용록필격뢰구복,균감측각계통출혈발생정황,동시행응혈지표(TT、PT、APTT、FIB)감측.의거미국국립위생연구원졸중량표(NIHSS)진행신경공능결손적치료전급치료후평분.결과 량조치료후NIHSS평분강저,치료조치료전[(15.04±2.53)분]여치료후[(6.38±1.19)분]차이유통계학의의(P＜0.05);대조조치료전[(16.26±2.71)분]여치료후[(9.45±3.27)분]차이유통계학의의(P＜0.05).치료조치료후NIHSS평분[(6.38±1.19)분]여대조조[(9.45±3.27)분]비교,차이유통계학의의(t=8.264,P＜0.05).치료조총유효솔위94.24％,고우대조조적81.48％,차이유통계학의의(x2=11.485,P＜0.05).량조환자균미출현명학적출혈반응.량조치료후응혈지표재상대안전범위내연장,차이균무통계학의의(균P＞0.05).결론 아사필림연합록필격뢰대급성뇌경사환자시안전유효적항혈소판치료방안.
Objective To explore the effect of aspirin combined with clopidogrel bisulfate in the treatment of patients with acute cerebral infarction.Methods 486 patients with acute cerebral infarction were selected and divided into the two groups in accordance with the random number table,243 cases in each group.The control group were given aspirin and conventional medical treatment.The observational group were given aspirin and clopidogrel bisulfate orally,system hemorrhage and TT,PT,APTT,FIB of both group were monitored.The efficacy was analyzed in accordance with the degree of neurological deficits score.Results The NIHSS of the observational group after treatment [(6.38 ± 1.19) points] was significantly lower than that of before [(15.04 ± 2.53) points] (P ＜ 0.05);The NIHSS of the control group after treatment [(9.45 ± 3.27) points] was significantly lower than before [(16.26 ± 2.71) points] (P ＜ 0.05);The NIHSS after treatment in the observational group [(6.38 ± 1.19) points] was significantly lower than that of the control group [(9.45 ± 3.27) points] (t =8.264,P ＜ 0.05).The total effective rate of the observational group was 94.24％,which was significantly higher than 81.48％ of the control group(x2 =11.485,P ＜ 0.05).No system hemorrhage was found in both groups.The coagulation index after treatment was higher than before but still in relatively safe range.There was no significant difference of coagulation index between observational group and control group (all P ＞ 0.05).Conclusion Using aspirin combined with clopidogrel bisulfate in acute cerebral infarction patients is safe and effective.
