CAJ | 학술논문

代谢组学研究是对生物体所有终末代谢产物进行全面、定性、定量分析研究的一门学科,可用于发现疾病相关生物标记物以及疾病发病机制的研究.代谢组学的研究流程主要包括代谢产物光谱数据的获得、数据的多元统计分析和代谢产物的鉴定等步骤.近些年来,代谢组学在骨科疾病的研究成为新的研究热点.开展最早也是最广泛的是对骨关节炎的研究,研究对象涉及血液、尿液、关节液和滑膜组织,发现了几十种差异表达代谢产物,揭示了多种骨关节炎异常代谢通路.此外,代谢组学研究也在骨质疏松症、强直性脊柱炎和骨肿瘤中开展起来,发现了多种潜在生物标记物,进一步揭示了疾病的发病机制.目前代谢组学研究在骨科领域的应用还处于起步阶段,前期的研究成果为代谢组学在其他骨科疾病中的应用奠定了基础.
대사조학연구시대생물체소유종말대사산물진행전면、정성、정량분석연구적일문학과,가용우발현질병상관생물표기물이급질병발병궤제적연구.대사조학적연구류정주요포괄대사산물광보수거적획득、수거적다원통계분석화대사산물적감정등보취.근사년래,대사조학재골과질병적연구성위신적연구열점.개전최조야시최엄범적시대골관절염적연구,연구대상섭급혈액、뇨액、관절액화활막조직,발현료궤십충차이표체대사산물,게시료다충골관절염이상대사통로.차외,대사조학연구야재골질소송증、강직성척주염화골종류중개전기래,발현료다충잠재생물표기물,진일보게시료질병적발병궤제.목전대사조학연구재골과영역적응용환처우기보계단,전기적연구성과위대사조학재기타골과질병중적응용전정료기출.
Metabolomics is a subject of systematic,qualitative and quantitative analysis of all metabolites in all organisms,which is applied to finding biomarkers and studying pathogenesis of diseases.Study procedures of metabolomics include data acquisition by spectroscopic/spectrometric techniques,multivariate statistical analysis and projection of the acquired metabolomic information.In recent years,metabolomics have gained popularity in orthopedic field.Metabolomic study of osteoarthritis was firstly conducted and widely developed.Metabolite profiles of different samples,including serum/plasma,urine,synovial fluid and synovial tissue,were studied and dozens of differential metabolites and several disturbed metabolic pathways were found.In addition,metabolomic studies of osteoporosis,ankylosing spondylitis and bone tumors were also conducted,which identified many potential biomarkers and made further understanding of pathogenesis of corresponding disease.However,metabolomic studies in orthopedic field just begin.More orthopedic diseases will be researched thank to the satisfactory results of previous reports.