CAJ | 학술논문

目的通过对高压氧治疗缺血性脑卒中患者一氧化氮(NO)含量变化相关文献的Meta分析,探讨高压氧对缺血性脑卒中的治疗作用.方法通过PUBMED、中国期刊网全文数据库(CNKI)、EMBASE等数据库及论文集检索国内外至2014年8月1日的相关文献.选择对缺血性脑卒中患者接受高压氧治疗患者与常规治疗患者治疗前后的对照研究,并对2组NO含量的变化进行Meta分析.结果 5篇文献符合纳入标准,涉及研究对象352例.高压氧治疗前后与常规治疗组前后NO含量经Meta分析的结果为OR =4.921(95％可信区间1.983 ～ 12.213),显示缺血性脑卒中患者经高压氧治疗后NO含量明显上升且为常规治疗组的4.921倍.结论高压氧治疗缺血性脑卒中有较好的应用前景,值得进一步临床研究.
목적 통과대고압양치료결혈성뇌졸중환자일양화담(NO)함량변화상관문헌적Meta분석,탐토고압양대결혈성뇌졸중적치료작용.방법 통과PUBMED、중국기간망전문수거고(CNKI)、EMBASE등수거고급논문집검색국내외지2014년8월1일적상관문헌.선택대결혈성뇌졸중환자접수고압양치료환자여상규치료환자치료전후적대조연구,병대2조NO함량적변화진행Meta분석.결과 5편문헌부합납입표준,섭급연구대상352례.고압양치료전후여상규치료조전후NO함량경Meta분석적결과위OR =4.921(95％가신구간1.983 ～ 12.213),현시결혈성뇌졸중환자경고압양치료후NO함량명현상승차위상규치료조적4.921배.결론 고압양치료결혈성뇌졸중유교호적응용전경,치득진일보림상연구.
Objective Researches have demonstrated that hyperbaric oxygen therapy (HBOT) could quickly elevate levels of nitric oxide (NO) in patients with ischemic stroke.By meta-analysis,this paper attempts to explore the efficacy of HBOT in patients with ischemic stroke.Methods Related literature was retrieved through the access of PUBMED,CNKI,EMBASE databanks from the inception to 2014-08-01,and controlled studies of patients treated with HBO and those treated with routine therapy were chosen from the retrieved literature,and then results of the meta-analysis were used to evaluate changes in the NO levels of ischemic stroke patients treated with HBO (the HBO group) and routine treatment (the sham group).Results There were 5 papers that were conformed to our selection criteria,with a total of 352 cases included.The meta-analysis showed that the odd ratio (OR) of NO levels for the patients in the HBO group and those of the sham group were respectively [4.921 (95％ CI was 1.983-12.213)].It was indicated that the NO level of the patients in the HBO group could obviously be elevated following HBO therapy,and was 4.921 times higher than that of the routine therapy group.Conclusions Present evidences indicated that HBO promised to have good clinical application in the treatment of patients with ischemic stroke,and was worth further clinical trial.