CAJ | 학술논문

目的探讨血浆同型半胱氨酸(HCY)及高敏C反应蛋白(hs-CRP)水平与阵发性心房颤动(房颤)导管消融术后复发的关系.方法连续选取2011年7月至2013年1月在南昌大学第二附属医院接受导管消融治疗的阵发性房颤患者126例,检测患者术前及术后1年血浆HCY和hs-CRP水平,随访1年后根据房颤复发情况分为复发组和非复发组.结果房颤复发组血浆HCY和hs-CRP水平无论是术前还是术后均高于非复发组(P＜0.05).非复发组血浆HCY与hs-CRP的水平均有下降趋势,而复发组却为上升趋势,并且血浆HCY与hs-CRP的水平呈正相关[(r=0.49,P＜0.01),(r=0.41,P＜0.01)].结论血浆HCY和hs-CRP与阵发性房颤导管消融术后复发密切相关,随访中两者水平不降低对其复发有一定的预测价值.
목적 탐토혈장동형반광안산(HCY)급고민C반응단백(hs-CRP)수평여진발성심방전동(방전)도관소융술후복발적관계.방법 련속선취2011년7월지2013년1월재남창대학제이부속의원접수도관소융치료적진발성방전환자126례,검측환자술전급술후1년혈장HCY화hs-CRP수평,수방1년후근거방전복발정황분위복발조화비복발조.결과 방전복발조혈장HCY화hs-CRP수평무론시술전환시술후균고우비복발조(P＜0.05).비복발조혈장HCY여hs-CRP적수평균유하강추세,이복발조각위상승추세,병차혈장HCY여hs-CRP적수평정정상관[(r=0.49,P＜0.01),(r=0.41,P＜0.01)].결론 혈장HCY화hs-CRP여진발성방전도관소융술후복발밀절상관,수방중량자수평불강저대기복발유일정적예측개치.
Objective To investigate the relationship of high-sensitivity C-reactive protein (hs-CRP) and homocysteine levels with recurrence of paroxysmal atrial fibrillation after catheter ablation.Methods A total of 126 patients with paroxysmal atrial fibrillation underwent radiofrequency catheter ablation.All patients were followed up for 1 year and were allocated to non-recurrence group or recurrence group according to recurrence of atrial fibrillation or not.Plasma levels of hs-CRP and homocysteine were determined before procedure and at one-year follow-up.Results Plasma hs-CRP and homocysteine levels pre-and post-procedure were higher in recurrence group than that in Non-recurrence group.Plasma hs-CRP and homocysteine in non-recurrence group had a downward trend,while the recurrent group had a rising trend.And we had found that the plasma levels of hs-CRP were positively correlated with homocysteine.Conclusions The levels of hs-CRP and homocysteine are closely correlated with recurrence of paroxysmal atrial fibrillation after catheter ablation.It is valuable to measure hs-CRP and homocysteine for predicting recurrence of paroxysmal atrial fibrillation after radiofrequency catheter ablation.