CAJ | 학술논문

目的：探讨高甘油三酯血症腰围表型(HTWC表型)与2型糖尿病性视网膜病变(DR)的相关性。方法将722例2型糖尿病患者以血甘油三酯≥1.7 mmoL/L、腰围男性≥85 cm或女性≥80 cm为切点,分为甘油三酯和腰围正常组、单纯高甘油三酯组、单纯腹型肥胖组、高甘油三酯血症腰围表型(HTWC)组,比较4组间 DR 的发生率及各生化指标,并进行 Logistic 回归分析。结果 HTWC 组患者体质量指数、腰围、臀围、收缩压、甘油三酯较非HTWC组升高(P<0.05或P<0.01),DR的发病率较高(P<0.05)。多因素 Logistic 回归分析表明,HTWC 表型是2型糖尿病患者合并DR的独立危险因素(OR =2.144,95%CI =1.219~3.770)。结论 HTWC表型是2型糖尿病患者合并DR的独立危险因素。
목적：탐토고감유삼지혈증요위표형(HTWC표형)여2형당뇨병성시망막병변(DR)적상관성。방법장722례2형당뇨병환자이혈감유삼지≥1.7 mmoL/L、요위남성≥85 cm혹녀성≥80 cm위절점,분위감유삼지화요위정상조、단순고감유삼지조、단순복형비반조、고감유삼지혈증요위표형(HTWC)조,비교4조간 DR 적발생솔급각생화지표,병진행 Logistic 회귀분석。결과 HTWC 조환자체질량지수、요위、둔위、수축압、감유삼지교비HTWC조승고(P<0.05혹P<0.01),DR적발병솔교고(P<0.05)。다인소 Logistic 회귀분석표명,HTWC 표형시2형당뇨병환자합병DR적독립위험인소(OR =2.144,95%CI =1.219~3.770)。결론 HTWC표형시2형당뇨병환자합병DR적독립위험인소。
Objective To investigate the association between hypertriglyceridemic-waist phenotype and diabetic retinopathy(DR)in patients with type 2 diabetes mellitus.Methods According to the cut point of plasma triglycerides concentration ≥1.7 mmol/L,waist circumference ≥85 cm in men or ≥80 cm in women,722 patients with type 2 diabetes mellitus were divided into four groups:normal waist circumference and triglycerides, normal waist circumference and hypertriglyceridemia,abdominal obesity and normal triglycerides,and hypertriglyceridemic waist (HTWC)group,DR incidence and correlation indices were compared,and Logistic regression analysis was adopted for study.Results The body mass index,waist circumference,hip circumference,systolic blood pressure and triglycerides in HTWC group were higher than those in non-HTWC group(P<0.05 or P<0.01),as well as higher DR incidence (P<0.05).Multiple logistic regression analysis revealed that HTWC was an independent risk factor of DR (OR =2.144,95%CI =1.219-3.770).Conclusion HTWC is significantly related to DR incidence in T2DM patients.