临床荟萃
臨床薈萃
림상회췌
CLINICAL FOCUS
2015年
6期
624-627
,共4页
冠心病%脂联素%绝经期
冠心病%脂聯素%絕經期
관심병%지련소%절경기
coronary disease%adiponectin%menopause
目的：探讨绝经后女性血清脂联素和冠心病及相关因素的关系。方法行冠状动脉造影的绝经后女性患者112例,根据冠状动脉造影结果分为冠心病组(n =74)和非冠心病组(n =38),检测两组空腹血糖、胰岛素、血脂、高敏 C 反应蛋白、纤维蛋白原以及血清脂联素水平,计算定量胰岛素敏感性检测指数(QUICKI),并以胰岛素抵抗的体内稳定状态模式评估法评价胰岛素抵抗指数(HOMA-IR)。结果冠心病组血清脂联素为11(10)mg/L,非冠心病组血清脂联素为8(7)mg/L,两组血清脂联素水平比较差异无统计学意义(P >0.05)。血清脂联素水平与QUICKI 呈正相关(r =0.244,P <0.05),与甘油三酯、胰岛素和 HOMA-IR 呈负相关(r 分别为-0.231、-0.198和-0.244,P <0.05)。血清脂联素水平不是冠心病的独立危险因素(P >0.05)。结论在绝经后女性中血清脂联素水平与冠心病无相关性,仅与糖代谢和血脂代谢有关。
目的：探討絕經後女性血清脂聯素和冠心病及相關因素的關繫。方法行冠狀動脈造影的絕經後女性患者112例,根據冠狀動脈造影結果分為冠心病組(n =74)和非冠心病組(n =38),檢測兩組空腹血糖、胰島素、血脂、高敏 C 反應蛋白、纖維蛋白原以及血清脂聯素水平,計算定量胰島素敏感性檢測指數(QUICKI),併以胰島素牴抗的體內穩定狀態模式評估法評價胰島素牴抗指數(HOMA-IR)。結果冠心病組血清脂聯素為11(10)mg/L,非冠心病組血清脂聯素為8(7)mg/L,兩組血清脂聯素水平比較差異無統計學意義(P >0.05)。血清脂聯素水平與QUICKI 呈正相關(r =0.244,P <0.05),與甘油三酯、胰島素和 HOMA-IR 呈負相關(r 分彆為-0.231、-0.198和-0.244,P <0.05)。血清脂聯素水平不是冠心病的獨立危險因素(P >0.05)。結論在絕經後女性中血清脂聯素水平與冠心病無相關性,僅與糖代謝和血脂代謝有關。
목적：탐토절경후녀성혈청지련소화관심병급상관인소적관계。방법행관상동맥조영적절경후녀성환자112례,근거관상동맥조영결과분위관심병조(n =74)화비관심병조(n =38),검측량조공복혈당、이도소、혈지、고민 C 반응단백、섬유단백원이급혈청지련소수평,계산정량이도소민감성검측지수(QUICKI),병이이도소저항적체내은정상태모식평고법평개이도소저항지수(HOMA-IR)。결과관심병조혈청지련소위11(10)mg/L,비관심병조혈청지련소위8(7)mg/L,량조혈청지련소수평비교차이무통계학의의(P >0.05)。혈청지련소수평여QUICKI 정정상관(r =0.244,P <0.05),여감유삼지、이도소화 HOMA-IR 정부상관(r 분별위-0.231、-0.198화-0.244,P <0.05)。혈청지련소수평불시관심병적독립위험인소(P >0.05)。결론재절경후녀성중혈청지련소수평여관심병무상관성,부여당대사화혈지대사유관。
Objective To evaluate the correlation between adiponectin level and coronary artery disease in postmenopausal women.Methods A total of 1 12 postmenopausal women patients with chest pain were devided into coronary artery desease (CAD)group and non-CAD group by coronary angiography.In all patients,adiponectin, fasting blood glucose,insulin,high-sensitive C- reactive protein,fibrinogen levels and lipid profile were measured. Quantitative insulin sensitivity check index (QUICKI)and Homeostasis Model Assessment of Insulin Resistance (HOMA-IR)were calculated to evaluate insulin resistance.Results Serum adiponectin level of CAD group was 1 1 (10)mg/L (median [interquartile range,IQR]),while serum adiponectin level of non-CAD group was 8 (7 )mg/L (median IQR).There was no significant difference in adiponectin level between CAD and non-CAD group (P >0.05).Spearman correlation analysis revealed a positive correlation between serum adiponectin level and QUICKI (r =0.244,P <0.05),and serum adiponectin level had a negative correlation with triglycerides,insulin and HOMA-IR (r =-0.231,-0.1 98 and -0.244,P <0.05,respectively).Multivariate logistic regression analysis showed that serum adiponectin level is not an independent risk factor for CAD (P >0.05).Conclusion Serum adiponectin level was not correlated with CAD in postmenopausal women and was only correlated with glycometabolism and lipid metabolism.
