CAJ | 학술논문

目的：评价重庆高校教职工估算肾小球滤过率（eGFR）与10年心血管疾病风险（10y CVDR）的关系。方法收集2013年4月重庆两所大学2630名教职工的体检资料。计算每个教职工的 eGFR和10y CVDR ，分析不同eGFR水平组10y CVDR的差异。结果纳入分析的职工平均年龄为（51．76±14．53）岁，男性明显高于女性。吸烟者占16．00％，高血压患者占15．20％，糖尿病患者占4．10％，男性吸烟、高血压、糖尿病患者明显多于女性（ P＜0．05）。男性身高、体质量、体质量指数、收缩压、舒张压、血清肌酐、三酰甘油、低密度脂蛋白及血糖均明显高于女性（ P＝0．000），高密度脂蛋白明显低于女性（ P＝0．000）。10y CVDR的中位数为1．25％，男性明显高于女性（2．85％ vs ．0．40％，P＜0．01）。eGFR≥90 mL · min－1·1．73 m2组、75 mL · min－1·1．73 m2≤eGFR＜90 mL · min－1·1．73 m2组、60 mL · min－1·1．73 m2≤eGFR＜75 mL · min－1·1．73 m2组及eGFR＜60 mL · min－1·1．73 m2组的10y CVDR中位数分别为0．74％、2．25％、5．58％和14．39％。非参数检验结果显示，与eGFR≥90 mL · min－1·1．73 m2组相比，其余各组的10y CVDR均明显增高。结论 eGFR是影响10y CVDR的重要因素，eGFR水平越低心血管疾病风险越高。
목적：평개중경고교교직공고산신소구려과솔（eGFR）여10년심혈관질병풍험（10y CVDR）적관계。방법수집2013년4월중경량소대학2630명교직공적체검자료。계산매개교직공적 eGFR화10y CVDR ，분석불동eGFR수평조10y CVDR적차이。결과납입분석적직공평균년령위（51．76±14．53）세，남성명현고우녀성。흡연자점16．00％，고혈압환자점15．20％，당뇨병환자점4．10％，남성흡연、고혈압、당뇨병환자명현다우녀성（ P＜0．05）。남성신고、체질량、체질량지수、수축압、서장압、혈청기항、삼선감유、저밀도지단백급혈당균명현고우녀성（ P＝0．000），고밀도지단백명현저우녀성（ P＝0．000）。10y CVDR적중위수위1．25％，남성명현고우녀성（2．85％ vs ．0．40％，P＜0．01）。eGFR≥90 mL · min－1·1．73 m2조、75 mL · min－1·1．73 m2≤eGFR＜90 mL · min－1·1．73 m2조、60 mL · min－1·1．73 m2≤eGFR＜75 mL · min－1·1．73 m2조급eGFR＜60 mL · min－1·1．73 m2조적10y CVDR중위수분별위0．74％、2．25％、5．58％화14．39％。비삼수검험결과현시，여eGFR≥90 mL · min－1·1．73 m2조상비，기여각조적10y CVDR균명현증고。결론 eGFR시영향10y CVDR적중요인소，eGFR수평월저심혈관질병풍험월고。
Objective To analyze the relationship between the estimated glomerular filtration rate (eGFR) and 10-year car‐diovascular disease risk (10y CVDR) in Chongqing college staff .Methods The physical examination data of the staff in two univer‐sities including 2630 persons were collected in April 2013 .The eGFR and 10y CVDR of each staff were calculated according to the standardized formula .The differences of 10y CVDR among different eGFR level groups were analyzed .Results The average age of all the staff were (51 .76 ± 14 .53) years old ,which in males was significant higher than that in females (P<0 .01) .The smokers , hypertension patients and diabetes patients accounted for 16 .00% ,15 .20% and 4 .10% respectively .The smokers ,hypertension and diabetes patients in males were significantly more than than those in females (P<0 .05) .The height ,weight ,BMI ,systolic pressure , diastolic pressure ,serum creatinine ,triglyceride ,LDL and blood glucose in males were significantly higher than those in females (P=0 .000) ,while HDL in males was significantly lower than that in females (P=0 .000) .The median of 10y CVDR was 1 .25% , males were significantly higher than females (2 .85% vs .0 .40% ,P<0 .01) .The median of 10y CVDR for the following groups were 0 .74% ,2 .25% ,5 .58% and 14 .39% respectively :eGFR≥90 mL · min-1 · 1 .73 m2 ,75 mL · min-1 · 1 .73 m2 ≤eGFR<90 mL · min-1 · 1 .73 m2 ,60 mL · min-1 · 1 .73 m2 ≤eGFR<75 mL · min-1 · 1 .73 m2 ,and eGFR<60 mL · min-1 · 1 .73 m2 .The results of the one‐way analysis of variance showed that compared to the 10y CVDR of the group with eGFR≥90 mL · min-1 · 1 .73 m2 ,which of the other three groups were all significantly increased .Conclusion eGFR is a significant factor impacting 10y CVDR . The lower the eGFR level ,the higher the risk of the 10y CVDR .