中国骨质疏松杂志
中國骨質疏鬆雜誌
중국골질소송잡지
CHINESE JOURNAL OF OSTEOPOROSIS
2015年
5期
575-578,585
,共5页
阙文君%冯正平%李晓宇%李济玲
闕文君%馮正平%李曉宇%李濟玲
궐문군%풍정평%리효우%리제령
骨密度%冠状动脉粥样硬化%病例对照研究
骨密度%冠狀動脈粥樣硬化%病例對照研究
골밀도%관상동맥죽양경화%병례대조연구
Bone mineral density%Coronary atherosclerosis%Case-control study
目的：从循证医学角度探讨绝经后女性骨密度与冠状动脉粥样硬化的关系，为冠心病早期防治提供理论依据。方法通过制定检索策略，在PubMed、EMbase、Ovid、EBSCO、CNKI、中国生物医学文献、维普中文科技期刊等数据库中检索近10年发表的相关文献，对所有符合要求的相关病例对照研究文献进行评价，应用Review Manager 5.2分析软件对数据进行分析。结果最终共纳入8个病例对照研究，包括骨密度降低组（低骨量和骨质疏松）986例患者，对照组926例患者。 Meta分析结果显示：各研究数据异质性检验结果I2＝0％，χ2＝6.52，P＝0.48，各研究间异质性小，采用固定效应模型，合并效应量OR＝2.81，95％CI为2.26－3.50，低骨密度组与骨量正常组冠状动脉粥样硬化的发病率差异有统计学意义。结论绝经后女性骨密度的降低与冠状动脉粥样硬化的发生有显著相关性，骨量减少和骨质疏松可能是冠状动脉粥样硬化的危险因素。
目的：從循證醫學角度探討絕經後女性骨密度與冠狀動脈粥樣硬化的關繫，為冠心病早期防治提供理論依據。方法通過製定檢索策略，在PubMed、EMbase、Ovid、EBSCO、CNKI、中國生物醫學文獻、維普中文科技期刊等數據庫中檢索近10年髮錶的相關文獻，對所有符閤要求的相關病例對照研究文獻進行評價，應用Review Manager 5.2分析軟件對數據進行分析。結果最終共納入8箇病例對照研究，包括骨密度降低組（低骨量和骨質疏鬆）986例患者，對照組926例患者。 Meta分析結果顯示：各研究數據異質性檢驗結果I2＝0％，χ2＝6.52，P＝0.48，各研究間異質性小，採用固定效應模型，閤併效應量OR＝2.81，95％CI為2.26－3.50，低骨密度組與骨量正常組冠狀動脈粥樣硬化的髮病率差異有統計學意義。結論絕經後女性骨密度的降低與冠狀動脈粥樣硬化的髮生有顯著相關性，骨量減少和骨質疏鬆可能是冠狀動脈粥樣硬化的危險因素。
목적：종순증의학각도탐토절경후녀성골밀도여관상동맥죽양경화적관계，위관심병조기방치제공이론의거。방법통과제정검색책략，재PubMed、EMbase、Ovid、EBSCO、CNKI、중국생물의학문헌、유보중문과기기간등수거고중검색근10년발표적상관문헌，대소유부합요구적상관병례대조연구문헌진행평개，응용Review Manager 5.2분석연건대수거진행분석。결과최종공납입8개병례대조연구，포괄골밀도강저조（저골량화골질소송）986례환자，대조조926례환자。 Meta분석결과현시：각연구수거이질성검험결과I2＝0％，χ2＝6.52，P＝0.48，각연구간이질성소，채용고정효응모형，합병효응량OR＝2.81，95％CI위2.26－3.50，저골밀도조여골량정상조관상동맥죽양경화적발병솔차이유통계학의의。결론절경후녀성골밀도적강저여관상동맥죽양경화적발생유현저상관성，골량감소화골질소송가능시관상동맥죽양경화적위험인소。
Objective To study the relationship between bone mineral density and coronary atherosclerosis in postmenopausal women from the perspective of evidence-based medicine, in order to provide theoretical basis for early prevention and treatment of coronary heart disease.Methods By making searching strategy, the related literatures published in recent 10 years were retrieved from PubMed, EMbase, Ovid, EBSCO, CNKI, SinoMed, VIP, and Wanfang Data etc.All the relevant case-control studies that met the requirements were evaluated.The data were analyzed using the software Review Manager 5.2.Results Eight case-control studies were enrolled, including 986 patients from the low bone mineral density group ( low bone mass and osteoporosis) and 926 patients from the control group.Meta analysis showed that the heterogeneity of the test results were I2 =0%, χ2 =6.52, and P=0.48.The heterogeneity of the studies was subtle by adopting the fixed effects model and merging effect quantity:OR=2.81, 95%of CI=2.26 -3.50.The difference of incidences of coronary atherosclerosis between low bone mineral density group and the normal bone mass group was statistically significant.Conclusion The declination of bone mineral density in postmenopausal women is significantly correlated with the occurrence of coronary atherosclerosis.Osteopenia and osteoporosis may be the risk factors for coronary atherosclerosis.
