中国生化药物杂志
中國生化藥物雜誌
중국생화약물잡지
CHINESE JOURNAL OF BIOCHEMICAL PHARMACEUTICS
2015年
5期
153-155
,共3页
加味玉屏风散%分泌型IgA%小儿%上呼吸道感染
加味玉屏風散%分泌型IgA%小兒%上呼吸道感染
가미옥병풍산%분비형IgA%소인%상호흡도감염
Jiawei Yuping Feng pulvis%sIgA%children%upper respiratory infection
目的：探讨分泌型IgA（ sIgA）联合加味玉屏风散治疗急性小儿上呼吸道感染的疗效。方法选择浙江省杭州市杭区第一人民医院上呼吸道感染的住院患儿160例，随机分为治疗组和对照组各80例，2组患儿均给予常规的对症及补液治疗，对照组给予中药加味玉屏风散，2次／天，每次3 g，口服；治疗组在此基础上，予分泌型IgA滴鼻，0．3～0．5 mg／（ kg? d），分6～8次。2组疗程均为7 d。观察2组治疗1个疗程后的总有效率，2组患儿的症状改善时间和2组不良反应的发生率。结果治疗组总有效率（96．25％）显著高于对照组（85．00％）（χ2＝5．96，P＜0．05）；治疗7 d后，治疗组的WBC和中性粒细胞百分率（neutrophil granulocyte ratio，NEUT％）较对照明显下降（P＜0．05）；治疗组中患儿发热、咳嗽咳痰、咽痛及鼻塞流涕症状缓解时间显著少于对照组（P均＜0．05）；2组的不良反应率均较低。结论分泌型IgA联合加味玉屏风散治疗小儿上呼吸道感染疗效确切，不良反应少。
目的：探討分泌型IgA（ sIgA）聯閤加味玉屏風散治療急性小兒上呼吸道感染的療效。方法選擇浙江省杭州市杭區第一人民醫院上呼吸道感染的住院患兒160例，隨機分為治療組和對照組各80例，2組患兒均給予常規的對癥及補液治療，對照組給予中藥加味玉屏風散，2次／天，每次3 g，口服；治療組在此基礎上，予分泌型IgA滴鼻，0．3～0．5 mg／（ kg? d），分6～8次。2組療程均為7 d。觀察2組治療1箇療程後的總有效率，2組患兒的癥狀改善時間和2組不良反應的髮生率。結果治療組總有效率（96．25％）顯著高于對照組（85．00％）（χ2＝5．96，P＜0．05）；治療7 d後，治療組的WBC和中性粒細胞百分率（neutrophil granulocyte ratio，NEUT％）較對照明顯下降（P＜0．05）；治療組中患兒髮熱、咳嗽咳痰、嚥痛及鼻塞流涕癥狀緩解時間顯著少于對照組（P均＜0．05）；2組的不良反應率均較低。結論分泌型IgA聯閤加味玉屏風散治療小兒上呼吸道感染療效確切，不良反應少。
목적：탐토분비형IgA（ sIgA）연합가미옥병풍산치료급성소인상호흡도감염적료효。방법선택절강성항주시항구제일인민의원상호흡도감염적주원환인160례，수궤분위치료조화대조조각80례，2조환인균급여상규적대증급보액치료，대조조급여중약가미옥병풍산，2차／천，매차3 g，구복；치료조재차기출상，여분비형IgA적비，0．3～0．5 mg／（ kg? d），분6～8차。2조료정균위7 d。관찰2조치료1개료정후적총유효솔，2조환인적증상개선시간화2조불량반응적발생솔。결과치료조총유효솔（96．25％）현저고우대조조（85．00％）（χ2＝5．96，P＜0．05）；치료7 d후，치료조적WBC화중성립세포백분솔（neutrophil granulocyte ratio，NEUT％）교대조명현하강（P＜0．05）；치료조중환인발열、해수해담、인통급비새류체증상완해시간현저소우대조조（P균＜0．05）；2조적불량반응솔균교저。결론분비형IgA연합가미옥병풍산치료소인상호흡도감염료효학절，불량반응소。
Objective To investigate clinical effect of sIgA combined with Jiawei Yuping Feng pulvis in treatment of upper respiratory infection ( URI) in children.Methods 160 children in hospital diagnosed with URI were randomly divided into treatment group and control group.With basic treatment, the control group were treated with Jiawei Yuping Feng pulvis, twice per day, 3 g each time, orally; treatment group on the basis of control group, secretory IgA via nasal drip, 0.3-0.5 mg/( kg? d) , dividing into 6-8 times.The treatment course was 7 days.The total efficiency, improvement of symptoms and adverse reactions were observed and compared.Results The total effective rate of treatment group (96.25%) was significantly higher than control group (85%)(χ2 =5.96, P<0.05).After 7 days of treatment, WBC and NEUT% of treatment group decreased significantly compared with control group ( P <0.05 ) .The fever, sore throat and runny nose, cough and expectoration symptom remission time of treatment group were significantly shorter than control group (P<0.05).Adverse reactions of both groups were lower.Conclusion It is effective to treat URI in children using sIgA combined with Jiawei Yuping Feng pulvis therapy, and it has few adverse reactions.
