中国生化药物杂志
中國生化藥物雜誌
중국생화약물잡지
CHINESE JOURNAL OF BIOCHEMICAL PHARMACEUTICS
2015年
5期
143-145,149
,共4页
胃癌%IL-6%IL-8%癌前病变%幽门螺杆菌
胃癌%IL-6%IL-8%癌前病變%幽門螺桿菌
위암%IL-6%IL-8%암전병변%유문라간균
gastric cancer%IL-6%IL-8%precancerous lesion%Helicobacter pylori
目的：探讨胃癌患者血清、胃液及组织中IL－6、IL－8水平变化与幽门螺杆菌感染关系。方法选取河北医科大学第一医院消化科胃炎及胃癌患者264例，根据胃镜组织活检病理确诊的结果分成3组，胃黏膜未见明显病变者为对照组（80例），胃黏膜癌前病变者为癌前病变组（84例）和胃黏膜癌病者为胃癌组（100例），再通过12 C呼吸实验的检测结果将以上3组分成对应的Hp阳性组及Hp阴性组。采用ELISA法检测患者血清中、胃液中IL－6、IL－8水平，采用双抗体夹心法检测胃黏膜组织中IL－6、IL－8水平，比较各组Hp阳性组患者治疗后Hp根除率。结果与对照组比较，癌前病变组及胃癌组血清、胃液及粘膜组织IL－6、IL－8较高（ P＜0．05），与癌前病变组比较，胃癌组血清、胃液及粘膜组织IL－6、IL－8较高（P＜0．05）。与HP阴性组比较，HP阳性组患者血清、胃液及粘膜组织IL－6、IL－8较高（P＜0．05）。三联用药抗幽门螺杆菌后，与胃癌组比较，癌前病变组与对照组Hp根除率较高（P＜0．05），对照组与癌前病变组Hp根除率比较差异无统计学意义。结论胃癌患者血清、胃液和胃黏膜组织中IL－6、IL－8水平升高，Hp阳性患者IL－6、IL－8水平更高；IL－6、IL－8升高可能是胃癌形成的机制，对胃癌的诊断、评估具有重要意义。
目的：探討胃癌患者血清、胃液及組織中IL－6、IL－8水平變化與幽門螺桿菌感染關繫。方法選取河北醫科大學第一醫院消化科胃炎及胃癌患者264例，根據胃鏡組織活檢病理確診的結果分成3組，胃黏膜未見明顯病變者為對照組（80例），胃黏膜癌前病變者為癌前病變組（84例）和胃黏膜癌病者為胃癌組（100例），再通過12 C呼吸實驗的檢測結果將以上3組分成對應的Hp暘性組及Hp陰性組。採用ELISA法檢測患者血清中、胃液中IL－6、IL－8水平，採用雙抗體夾心法檢測胃黏膜組織中IL－6、IL－8水平，比較各組Hp暘性組患者治療後Hp根除率。結果與對照組比較，癌前病變組及胃癌組血清、胃液及粘膜組織IL－6、IL－8較高（ P＜0．05），與癌前病變組比較，胃癌組血清、胃液及粘膜組織IL－6、IL－8較高（P＜0．05）。與HP陰性組比較，HP暘性組患者血清、胃液及粘膜組織IL－6、IL－8較高（P＜0．05）。三聯用藥抗幽門螺桿菌後，與胃癌組比較，癌前病變組與對照組Hp根除率較高（P＜0．05），對照組與癌前病變組Hp根除率比較差異無統計學意義。結論胃癌患者血清、胃液和胃黏膜組織中IL－6、IL－8水平升高，Hp暘性患者IL－6、IL－8水平更高；IL－6、IL－8升高可能是胃癌形成的機製，對胃癌的診斷、評估具有重要意義。
목적：탐토위암환자혈청、위액급조직중IL－6、IL－8수평변화여유문라간균감염관계。방법선취하북의과대학제일의원소화과위염급위암환자264례，근거위경조직활검병리학진적결과분성3조，위점막미견명현병변자위대조조（80례），위점막암전병변자위암전병변조（84례）화위점막암병자위위암조（100례），재통과12 C호흡실험적검측결과장이상3조분성대응적Hp양성조급Hp음성조。채용ELISA법검측환자혈청중、위액중IL－6、IL－8수평，채용쌍항체협심법검측위점막조직중IL－6、IL－8수평，비교각조Hp양성조환자치료후Hp근제솔。결과여대조조비교，암전병변조급위암조혈청、위액급점막조직IL－6、IL－8교고（ P＜0．05），여암전병변조비교，위암조혈청、위액급점막조직IL－6、IL－8교고（P＜0．05）。여HP음성조비교，HP양성조환자혈청、위액급점막조직IL－6、IL－8교고（P＜0．05）。삼련용약항유문라간균후，여위암조비교，암전병변조여대조조Hp근제솔교고（P＜0．05），대조조여암전병변조Hp근제솔비교차이무통계학의의。결론위암환자혈청、위액화위점막조직중IL－6、IL－8수평승고，Hp양성환자IL－6、IL－8수평경고；IL－6、IL－8승고가능시위암형성적궤제，대위암적진단、평고구유중요의의。
Objective To investigate relationship between IL-6, IL-8 and Helicobacter pylori in patients with gastric cancer.Methods 264 cases patients with gastric cancer and gastritis were selected, and divided into control group, precancerous lesion group and gastric cancer group according to the tissue biopsy, then each group were divided into positive group and negative group according to 12 C test.IL-6 and IL-8 in serum and gastric juice were detected by ELISA, while in gastric mucosa by double antibody sandwich method.Results Compared with control group, IL-6 and IL-8 in serum, gastric juiceand gastric mucosa were higher ( P<0.05 ) .Compared with precancerous lesion group, IL-6 and IL-8 in serum, gastric juice and gastric mucosa were higher(P<0.05).Compared with Hp negative group, IL-6 and IL-8 in serum, gastric juice and gastric mucosa were higher(P<0.05). Compared with gastric cancer group, Hp eradication rate of precancerous lesion group and control group was higher, respectively ( P<0.05 ) . Conclusion IL-6 and IL-8 in gastric cancer patients’ serum, gastric juice and gastric mucosa increased, which is higher in Hp positive group.The levels of IL-6, IL-8 maybe the key mechanism of the formation of gastric cancer, which has important sense of assessment and diagnosis of gastric cancer.
