CAJ | 학술논문

目的：探讨银杏叶黄酮注射液对急性脑梗死（ acute cerebral infarction，ACI）患者脑损伤因子的影响及意义。方法选取2014年6月～2015年2月已确诊为急性脑梗死的患者180例，根据随机数字表法随机分为2组：对照组88例，行临床常规疗法治疗；实验组92例，在与对照组相同的临床常规治疗基础上加用银杏叶黄酮注射液，检测2组患者的临床疗效、神经功能缺损评分、及血清HIF－1α、TNF－α、Caspase－3水平，进而对比分析2种治疗方法的临床疗效。结果实验组患者经治疗后临床疗效更优于对照组，有效率显著优于对照组（ P＜0．05）；神经功能缺损评分显著低于对照组（ P＜0．05）；血清HIF－1α、Caspase－3、TNF－α水平低于对照组（P＜0．05），均有统计学意义。结论银杏叶黄酮对急性脑梗死患者据有较好的临床疗效，且能有效改善患者神经功能缺损症状，对临床治疗脑梗死具有重要意义。
목적：탐토은행협황동주사액대급성뇌경사（ acute cerebral infarction，ACI）환자뇌손상인자적영향급의의。방법선취2014년6월～2015년2월이학진위급성뇌경사적환자180례，근거수궤수자표법수궤분위2조：대조조88례，행림상상규요법치료；실험조92례，재여대조조상동적림상상규치료기출상가용은행협황동주사액，검측2조환자적림상료효、신경공능결손평분、급혈청HIF－1α、TNF－α、Caspase－3수평，진이대비분석2충치료방법적림상료효。결과실험조환자경치료후림상료효경우우대조조，유효솔현저우우대조조（ P＜0．05）；신경공능결손평분현저저우대조조（ P＜0．05）；혈청HIF－1α、Caspase－3、TNF－α수평저우대조조（P＜0．05），균유통계학의의。결론은행협황동대급성뇌경사환자거유교호적림상료효，차능유효개선환자신경공능결손증상，대림상치료뇌경사구유중요의의。
Objective To explore effect of ginkgetin injection on brain damage factor in patients with acute cerebral infarction.Methods 180 cases of acute cerebral infarction patients were selected from June 2014 to February 2015, and divided into experiment group and control group.88 cases in control group were treated with clinical routine therapy, 92 cases in experimental group were treated on base of the control with ginkgetin injection, 2 weeks for a course.The clinical efficacy, MESS and serum HIF-1α, TNF-α, Caspase-3, were detected and compared.Results The clinical efficacy of the experiment group was better than that of control group(P<0.05),and the MESS of the experiment group was lower than the control group(P<0.05).Serum HIF-1α, Caspase-3, TNF-αlevels were lower than the control group(P<0.05).Conclusion Ginkgetin injection can effectively improve the patient’s neurological symptoms, it is of great significance to the clinical treatment of cerebral infarction.