中国生化药物杂志
中國生化藥物雜誌
중국생화약물잡지
CHINESE JOURNAL OF BIOCHEMICAL PHARMACEUTICS
2015年
5期
130-133
,共4页
血必净注射液%脓毒症%内毒素%脾脏特异性免疫功能
血必淨註射液%膿毒癥%內毒素%脾髒特異性免疫功能
혈필정주사액%농독증%내독소%비장특이성면역공능
Xuebijing injection%sepsis%endotoxin%specific immune function of spleen
目的:探讨血必净射液对急性脓毒症患者血清Th1/2、内毒素及脾脏特异性免疫功能的影响及其意义。方法选取2014年9月~2015年1月于漯河医学高等专科学校第一附属医院确诊为脓毒症的患者110例,根据随机数字表法随机分为2组:对照组55例,行临床常规治疗;实验组55例,在与对照组基础上加用血必净注射液。比较2组患者的血流动力学、血清Th1/2、内毒素及脾脏特异性免疫功能。结果实验组患者心率低于对照组(P<0.05),平均动脉压以及中心静脉压高于对照组(P<0.05),缩血管药物应用低于对照组(P<0.05),Th1/Th2比值高于对照组(P<0.05),血清内毒素水平低于对照组(P<0.05),淋巴细胞增殖、HLA-DR比例高于对照组(P<0.05),caspase-3细胞阳性指数低于对照组(P<0.05)。结论血必净注射液能有效改善脓毒症患者血流动力学异常,调节血清Th1/Th2水平,降低血清内毒素水平,提高脾脏特异性免疫功能,对临床治疗脓毒症具有重要意义。
目的:探討血必淨射液對急性膿毒癥患者血清Th1/2、內毒素及脾髒特異性免疫功能的影響及其意義。方法選取2014年9月~2015年1月于漯河醫學高等專科學校第一附屬醫院確診為膿毒癥的患者110例,根據隨機數字錶法隨機分為2組:對照組55例,行臨床常規治療;實驗組55例,在與對照組基礎上加用血必淨註射液。比較2組患者的血流動力學、血清Th1/2、內毒素及脾髒特異性免疫功能。結果實驗組患者心率低于對照組(P<0.05),平均動脈壓以及中心靜脈壓高于對照組(P<0.05),縮血管藥物應用低于對照組(P<0.05),Th1/Th2比值高于對照組(P<0.05),血清內毒素水平低于對照組(P<0.05),淋巴細胞增殖、HLA-DR比例高于對照組(P<0.05),caspase-3細胞暘性指數低于對照組(P<0.05)。結論血必淨註射液能有效改善膿毒癥患者血流動力學異常,調節血清Th1/Th2水平,降低血清內毒素水平,提高脾髒特異性免疫功能,對臨床治療膿毒癥具有重要意義。
목적:탐토혈필정사액대급성농독증환자혈청Th1/2、내독소급비장특이성면역공능적영향급기의의。방법선취2014년9월~2015년1월우탑하의학고등전과학교제일부속의원학진위농독증적환자110례,근거수궤수자표법수궤분위2조:대조조55례,행림상상규치료;실험조55례,재여대조조기출상가용혈필정주사액。비교2조환자적혈류동역학、혈청Th1/2、내독소급비장특이성면역공능。결과실험조환자심솔저우대조조(P<0.05),평균동맥압이급중심정맥압고우대조조(P<0.05),축혈관약물응용저우대조조(P<0.05),Th1/Th2비치고우대조조(P<0.05),혈청내독소수평저우대조조(P<0.05),림파세포증식、HLA-DR비례고우대조조(P<0.05),caspase-3세포양성지수저우대조조(P<0.05)。결론혈필정주사액능유효개선농독증환자혈류동역학이상,조절혈청Th1/Th2수평,강저혈청내독소수평,제고비장특이성면역공능,대림상치료농독증구유중요의의。
Objective To investigate effect of Xuebijing injection on Th1/2, endotoxin and immune factors in patients with acute sepsis.Methods 110 cases of sepsis patients were selected and divided into two groups from September 2014 to January 2015.The control group of 55 cases were treated by clinical routine therapy, the experiment group of 55 cases were treated with Xuebijing injection on the basis of control group.Hemodynamics, serum Th1/2, endotoxin and specific immunological function of spleen were compared.Results After treatment, the heart rate of experiment group was significantly lower than control group (P<0.05), the mean arterial pressure and central venous pressure were higher than control group (P<0.05), vasoconstrictive drugs application amount was less than control group ( P<0.05 ) , the ratio of Th1/Th2 was higher than control group ( P<0.05 ) , serum endotoxin levels was lower than control group (P<0.05), and the ratio of HLA-DR, lymphocyte proliferation and positive index of caspase-3 cells were lower than control group(P<0.05).Conclusion Xuebijing injection can effectively improve haemodynamics in patients with sepsis, regulate serum Th1/Th2 levels, reduce serum endotoxin level and enhance specific immune function of spleen, which has important significance for clinical treatment of sepsis.