CAJ | 학술논문

目的：探讨乳腺癌患者血清中组织多肽特异性抗原（ TPS）、血管内皮生长因子（ VEGF）的表达及其与临床病理关系的研究。方法选取收治的原发性乳腺癌女性患者68例，乳腺纤维瘤的女性患者36例作为对照组。采用ELISA检测法检测2组患者血清中TPS和VEGF水平，比较实验组TPS和VEGF水平与TNM分期及临床病理特征的关系。结果实验组患者TPS和VEGF水平明显高于对照组，差异有统计学意义（P＜0．05）；术后实验组TPS、VEGF水平低于术前水平（P＜0．01）；TPS、VEGF水平在乳腺癌0期与Ⅰ期中差异无统计学意义；随着肿瘤分期增加，TPS、VEGF上升（ P＜0．05）；VEGF表达水平在肿瘤直径≤2 cm组明显低于肿瘤直径＞2 cm组（ P＜0．05）。腋下淋巴结转移组与腋下淋巴结无转移组患者血清中TPS和VEGF浓度差异有统计学意义（ P＜0．05）。TPS浓度水平在雌激素受体阴性、孕激素受体阴性中明显高于雌激素和孕激素阳性组（ P＜0．05）。结论乳腺癌患者血清中TPS、VEGF水平呈现高表达状态，TPS、VEGF水平表达与乳腺癌患者腋窝淋巴结转移、雌激素受体、孕激素受体有关。
목적：탐토유선암환자혈청중조직다태특이성항원（ TPS）、혈관내피생장인자（ VEGF）적표체급기여림상병리관계적연구。방법선취수치적원발성유선암녀성환자68례，유선섬유류적녀성환자36례작위대조조。채용ELISA검측법검측2조환자혈청중TPS화VEGF수평，비교실험조TPS화VEGF수평여TNM분기급림상병리특정적관계。결과실험조환자TPS화VEGF수평명현고우대조조，차이유통계학의의（P＜0．05）；술후실험조TPS、VEGF수평저우술전수평（P＜0．01）；TPS、VEGF수평재유선암0기여Ⅰ기중차이무통계학의의；수착종류분기증가，TPS、VEGF상승（ P＜0．05）；VEGF표체수평재종류직경≤2 cm조명현저우종류직경＞2 cm조（ P＜0．05）。액하림파결전이조여액하림파결무전이조환자혈청중TPS화VEGF농도차이유통계학의의（ P＜0．05）。TPS농도수평재자격소수체음성、잉격소수체음성중명현고우자격소화잉격소양성조（ P＜0．05）。결론유선암환자혈청중TPS、VEGF수평정현고표체상태，TPS、VEGF수평표체여유선암환자액와림파결전이、자격소수체、잉격소수체유관。
Objective To investigate expression of TPS, VEGF of beast cancer patients and relationship with clinical pathological.Methods 68 cases of breast cancer were selected as experiment group, 36 cases with breast fibroma were selected as control group.TPS and VEGF were detected by elisa of patients before and after treatment.Serum TPS and VEGF levels and TNM staging were compared after operation.Results TPS and VEGF of the experiment group were higher than control group(P<0.05).TPS and VEGF of experiment group after operation were higher than before operation.TPS and VEGF increased with the grade of tumor, but there was no significance between grade Ⅰ and 0.The expression of VEGF in tumor diameter≤2 cm group was significantly lower than >2 cm group(P<0.05).TPS and VEGF of axillary lymph node metastasis group and axillary lymph node metastasis had significant difference(P<0.05).The concentration of TPS was significantly higher than that of estrogen and progesteronepositive group in estrogen receptor negative, progesterone receptor negative (P<0.05).Conclusion TPS, VEGF levels in the serum of breast cancer patients showed high expression, the expression of TPS, VEGF levels related to axillary lymph node metastasis, estrogen receptor, progesterone receptor.