CAJ | 학술논문

目的：系统评价鼠神经生长因子对骨折愈合的影响。方法计算机检索 Cochrane Database、Pubmed、EMbase、CNKI、VlP、万方数据库和CBM中关于神经生长因子对骨折患者的作用的随机对照试验（randomized controlled trial，RCT），同时追索纳入文献的参考文献。检索时限均为从建库至2014年5月。由3名研究者根据GRADE系统推荐分级方法，对纳入研究的质量进行严格评价和资料提取，对符合质量标准的 RCT 进行Meta分析。统计学分析采用 RevMan 5．0软件和 GRAED proiler软件。结果共纳入5篇随机对照试验研究，全部为中文文献。 Meta分析2个结局指标显示：愈合时间的变化，2组差异有统计学意义[MD＝－8．74，95％CI（－9．79，－7．68），P＜0．0001]。不良反应2组差异亦有统计学意义[OR＝14．66，95％CI（1．89，113．99），P＝0．01]。每个结局的GRADE系统推荐分级均为低等级。结论鼠神经生长因子可减少患者的愈合时间，但不良反应有一定增加。
목적：계통평개서신경생장인자대골절유합적영향。방법계산궤검색 Cochrane Database、Pubmed、EMbase、CNKI、VlP、만방수거고화CBM중관우신경생장인자대골절환자적작용적수궤대조시험（randomized controlled trial，RCT），동시추색납입문헌적삼고문헌。검색시한균위종건고지2014년5월。유3명연구자근거GRADE계통추천분급방법，대납입연구적질량진행엄격평개화자료제취，대부합질량표준적 RCT 진행Meta분석。통계학분석채용 RevMan 5．0연건화 GRAED proiler연건。결과공납입5편수궤대조시험연구，전부위중문문헌。 Meta분석2개결국지표현시：유합시간적변화，2조차이유통계학의의[MD＝－8．74，95％CI（－9．79，－7．68），P＜0．0001]。불량반응2조차이역유통계학의의[OR＝14．66，95％CI（1．89，113．99），P＝0．01]。매개결국적GRADE계통추천분급균위저등급。결론서신경생장인자가감소환자적유합시간，단불량반응유일정증가。
Objective To evaluate the effect of mouse nerve growth factor on fracture healing.Methods Cochrane library, Pubmed, EMbase, CNKI,VIP,Wanfang Data and CBM were searched for the randomized controlled trials(RCTs)of mouse nerve growth factor on fracture healing from the date of establishment of the databases to May 2014.Three independent rese archers evaluated the included studies using GRADE,according to recommend classification method of GRADE system by three researchers,crtical evaluated and data extracted of the quality of the included studies,which conform to the quality standard of RCT was analyzed by Meta analysis.The extracted data were analyzed by RevMan 5.0 and GRAED proiler.Results A total 5 trials were discovered and all of these were in Chinese.Compared with conventional treatment was improved a lot[MD =-8.74,95%CI( -9.79,-7.68),P<0.0001].However, adverse drug reaction in patients with mouse nerve growth factor were increased[OR =14.66,95%CI(1.89, 113.99),P=0.01].The both outcomes were low quality in the GRADE system.Conclusion Mouse nerve growth factor can improve fracture healing and the side effects will also increase.