中国生化药物杂志
中國生化藥物雜誌
중국생화약물잡지
CHINESE JOURNAL OF BIOCHEMICAL PHARMACEUTICS
2015年
5期
66-71
,共6页
斑蝥酸钠注射液%原发性肝癌%TACE%随机对照试验%Meta分析
斑蝥痠鈉註射液%原髮性肝癌%TACE%隨機對照試驗%Meta分析
반모산납주사액%원발성간암%TACE%수궤대조시험%Meta분석
disodium cantharidinate injection%hepatocellular carcinoma%TACE%randomized controlled trial%Meta-analysis
目的：评价斑蝥酸钠注射液联合肝动脉化疗栓塞术（ transcatheter arterial chemoembolization，TACE）与单独使用TACE治疗原发性肝癌（ hepatocellular carcinoma，HCC）的有效性及安全性。方法检索Pubmed、CNKI、万方和VIP等数据库，纳入斑蝥酸钠注射液联合TACE治疗HCC与TACE治疗比较的随机对照试验。评价纳入研究质量并进行Meta分析。结果纳入7个随机对照试验，共562例患者。 Meta分析结果表明：与对照组相比，斑蝥酸钠注射液联合TACE治疗能提高HCC治疗的有效率[ RR＝1．31，95％CI（1．10，1．56）]、临床受益率[RR＝1．20，95％CI（1．04，1．39）]，改善患者生活质量[RR＝1．60，95％CI（1．26，2．03）]，并能提高1年生存率[RR＝1．57，95％CI（1．28，1．93）]和2年生存率[RR＝2．08，95％CI（1．46，2．97）]。结论斑蝥酸钠注射液联合TACE治疗HCC优于单用TACE治疗。
目的：評價斑蝥痠鈉註射液聯閤肝動脈化療栓塞術（ transcatheter arterial chemoembolization，TACE）與單獨使用TACE治療原髮性肝癌（ hepatocellular carcinoma，HCC）的有效性及安全性。方法檢索Pubmed、CNKI、萬方和VIP等數據庫，納入斑蝥痠鈉註射液聯閤TACE治療HCC與TACE治療比較的隨機對照試驗。評價納入研究質量併進行Meta分析。結果納入7箇隨機對照試驗，共562例患者。 Meta分析結果錶明：與對照組相比，斑蝥痠鈉註射液聯閤TACE治療能提高HCC治療的有效率[ RR＝1．31，95％CI（1．10，1．56）]、臨床受益率[RR＝1．20，95％CI（1．04，1．39）]，改善患者生活質量[RR＝1．60，95％CI（1．26，2．03）]，併能提高1年生存率[RR＝1．57，95％CI（1．28，1．93）]和2年生存率[RR＝2．08，95％CI（1．46，2．97）]。結論斑蝥痠鈉註射液聯閤TACE治療HCC優于單用TACE治療。
목적：평개반모산납주사액연합간동맥화료전새술（ transcatheter arterial chemoembolization，TACE）여단독사용TACE치료원발성간암（ hepatocellular carcinoma，HCC）적유효성급안전성。방법검색Pubmed、CNKI、만방화VIP등수거고，납입반모산납주사액연합TACE치료HCC여TACE치료비교적수궤대조시험。평개납입연구질량병진행Meta분석。결과납입7개수궤대조시험，공562례환자。 Meta분석결과표명：여대조조상비，반모산납주사액연합TACE치료능제고HCC치료적유효솔[ RR＝1．31，95％CI（1．10，1．56）]、림상수익솔[RR＝1．20，95％CI（1．04，1．39）]，개선환자생활질량[RR＝1．60，95％CI（1．26，2．03）]，병능제고1년생존솔[RR＝1．57，95％CI（1．28，1．93）]화2년생존솔[RR＝2．08，95％CI（1．46，2．97）]。결론반모산납주사액연합TACE치료HCC우우단용TACE치료。
Objective To evaluate the efficacy and safety of disodium cantharidinate injection combined with transcatheter arterial chemoembolization(TACE) compared with TCAE alone in the treatment of hepatocellular carcinoma(HCC) by meta-analysis.Methods Databases of Pubmed, CNKI,Wangfang and VIP were searched electronically, and the randomized controlled trials about disodium cantharidinate injection combined with TACE in the treatment of HCC were included.Meta-analyses were conducted after the quality of the included studies was assessed.Results Seven eligible studies that included a total of 562 HCC patients were identified in the present meta-analysis.The combined results showed that disodium cantharidinate injection combined with TACE in the treatment of HCC, compared with TACE alone, could increase effective rate ( RR =1.31, 95%CI 1.10-1.56) and clinical benefit rate (RR =1.20, 95%CI 1.04 -1.39), improve the life quality (RR =1.60, 95%CI 1.26 -2.03) and improved the 1, 2 year survival (RR =1.57 with 95%CI 1.28 -1.93 and RR =2.08 with 95%CI 1.46 -2.97, respectively).Conclusion Meta-analysis indicates that the efficacy of disodium cantharidinate injection combined with TACE is superior to TACE alone for the patients with HCC.
