中国生化药物杂志
中國生化藥物雜誌
중국생화약물잡지
CHINESE JOURNAL OF BIOCHEMICAL PHARMACEUTICS
2015年
5期
29-32
,共4页
覃引%邱树毅%张振%周剑丽%胡女丹
覃引%邱樹毅%張振%週劍麗%鬍女丹
담인%구수의%장진%주검려%호녀단
天麻素%脂质体%包封率%制备工艺%正交试验
天痳素%脂質體%包封率%製備工藝%正交試驗
천마소%지질체%포봉솔%제비공예%정교시험
gastrodine%liposome%entrapment efficiency%preparation process%orthogonal test
目的:研究天麻素脂质体的最佳制备工艺,并表征其结构。方法采用薄膜—超声法制备。以包封率为指标,卵磷脂与胆固醇之间的质量比、油水相的体积比和超声时间为考察因素,采用L9(34)正交试验法优化制备工艺;显微镜下观察脂质体的形态、粒径大小和分布,并测定其包封率和稳定性。结果回归方程式为Y=239.75X+0.0207(n=5),R2=0.9996,在0.002~0.010 mg/mL范围内具有良好的线性关系。最佳工艺为:卵磷脂与胆固醇的质量比为4:1、水油相的体积比为3:1、超声时间控制为60 min;脂质体呈现类球形或椭圆形,形态规则、大小均匀;平均包封率为60.65%,平均粒径分布为327 nm,稳定性良好。结论优选后的制备工艺稳定,所需设备简单,包封率较高,粒径较均匀,可适用于包埋水溶性药物。
目的:研究天痳素脂質體的最佳製備工藝,併錶徵其結構。方法採用薄膜—超聲法製備。以包封率為指標,卵燐脂與膽固醇之間的質量比、油水相的體積比和超聲時間為攷察因素,採用L9(34)正交試驗法優化製備工藝;顯微鏡下觀察脂質體的形態、粒徑大小和分佈,併測定其包封率和穩定性。結果迴歸方程式為Y=239.75X+0.0207(n=5),R2=0.9996,在0.002~0.010 mg/mL範圍內具有良好的線性關繫。最佳工藝為:卵燐脂與膽固醇的質量比為4:1、水油相的體積比為3:1、超聲時間控製為60 min;脂質體呈現類毬形或橢圓形,形態規則、大小均勻;平均包封率為60.65%,平均粒徑分佈為327 nm,穩定性良好。結論優選後的製備工藝穩定,所需設備簡單,包封率較高,粒徑較均勻,可適用于包埋水溶性藥物。
목적:연구천마소지질체적최가제비공예,병표정기결구。방법채용박막—초성법제비。이포봉솔위지표,란린지여담고순지간적질량비、유수상적체적비화초성시간위고찰인소,채용L9(34)정교시험법우화제비공예;현미경하관찰지질체적형태、립경대소화분포,병측정기포봉솔화은정성。결과회귀방정식위Y=239.75X+0.0207(n=5),R2=0.9996,재0.002~0.010 mg/mL범위내구유량호적선성관계。최가공예위:란린지여담고순적질량비위4:1、수유상적체적비위3:1、초성시간공제위60 min;지질체정현류구형혹타원형,형태규칙、대소균균;평균포봉솔위60.65%,평균립경분포위327 nm,은정성량호。결론우선후적제비공예은정,소수설비간단,포봉솔교고,립경교균균,가괄용우포매수용성약물。
Objective To study the optimum preparation process of gastrodin liposome, characterization its structure.Methods Perpared gastrodin liposome with film-ultrasonic method.The entrapment efficiency as index, quality between lecithin and cholesterol ratio, oil-water phase volume ratio and ultrasonic time as factors by L9 (34 ) orthogonal test to optimize the preparation process.Observed the liposome morphology, particle size and distribution under the microscope, and determined the entrapment efficiency and stability.Results Regression equation was Y=239.75 +0.0207X(n=5), R2 =0.9996, 0.002 to 0.010 mg/mL had a good linear relationship.The optimum of preparation process: lecithin and cholesterol quality ratio was 4:1, water and oil phase volume ratio of 3:1, ultrasonic time control for 60 min;Liposomes showed spherical or oval shape, regular shape, uniform size.The average entrapment efficiency was 60.65%, the average particle size distribution at 327 nm, and it had good stability.Conclusion The preparation of gastrodine liposome has advantages of simple, higher entrapment efficiency and even particle size.The method can be used for embedded water-soluble medicine.