CAJ | 학술논문

目的：研究重型颅脑损伤后患者凝血功能的变化及其对预后判断的价值。方法选取66例重型颅脑损伤患者作为观察组，分别在入院急诊时(D0)及入院后第2(D2)、3(D3)、7(D7)天检测活化部分凝血活酶时间(APTT)、凝血酶原时间(PT)、凝血酶时间(TT)、纤维蛋白原(FIB)和 D-二聚体(DD)，并以同期66例单纯头皮裂伤患者作为对照组， D0检测凝血功能指标。对两组 D0期的凝血功能检测结果进行分析和比较。结果两组比较， D2、D7的 APTT 值， D0、D2的 PT 值， D0、D2、D3的 FIB 值差异均具有统计学意义(P<0.05)；TT 值各时段和对照组比较，差异均无统计学意义(P>0.05)。结论重型颅脑损伤患者的凝血功能异常较明显，测定相关凝血功能指标，对颅脑损伤的严重程度及预后判断有参考价值。
목적：연구중형로뇌손상후환자응혈공능적변화급기대예후판단적개치。방법선취66례중형로뇌손상환자작위관찰조，분별재입원급진시(D0)급입원후제2(D2)、3(D3)、7(D7)천검측활화부분응혈활매시간(APTT)、응혈매원시간(PT)、응혈매시간(TT)、섬유단백원(FIB)화 D-이취체(DD)，병이동기66례단순두피렬상환자작위대조조， D0검측응혈공능지표。대량조 D0기적응혈공능검측결과진행분석화비교。결과량조비교， D2、D7적 APTT 치， D0、D2적 PT 치， D0、D2、D3적 FIB 치차이균구유통계학의의(P<0.05)；TT 치각시단화대조조비교，차이균무통계학의의(P>0.05)。결론중형로뇌손상환자적응혈공능이상교명현，측정상관응혈공능지표，대로뇌손상적엄중정도급예후판단유삼고개치。
Objective To research changes in coagulation function after severe craniocerebral injury and its value for prognosis judgment. Methods There were 66 patients with severe craniocerebral injury in observation group. Their activated partial thromboplastin time (APTT), prothrombin time (PT), thrombin time (TT), fibrinogen (FIB), and D-dimmer (DD) were detected in admission (D0) and after 2 (D2), 3 (D3), 7 (D7) d. Another 66 patients with scalp laceration as control group received detection of coagulation function indicator at D0. Analysis and comparison were made on coagulation function indicators of the two groups at D0. Results Comparisons between the two groups showed there were statistically significant differences of APTT values between D2 and D7, PT values between D0 and D2, and FIB values between D0, D2, and D3 (P<0.05). The differences of TT values in each time points between observation group and control group all had no statistical significance (P>0.05). Conclusion Coagulation abnormality is obvious in severe craniocerebral injury patients. Thus detection of related coagulation function indicator can provide referring value for judgment of severity of craniocerebral injury and its prognosis.