中外医疗
中外醫療
중외의료
CHINA FOREIGN MEDICAL TREATMENT
2015年
11期
84-85
,共2页
肾病综合征%儿童%低分子肝素%疗效分析
腎病綜閤徵%兒童%低分子肝素%療效分析
신병종합정%인동%저분자간소%료효분석
Nephrotic syndrome%Children%Low molecular heparin%Effect analysis
目的：探究分析低分子肝素在小儿肾病综合征中的临床疗效及其治疗的安全性。方法采用回顾性分析的方法，分析了该院儿科在2013年1月—2014年1月间收治的108例肾病综合征的患儿的临床资料。根据治疗药物的不同，将108例患儿随机分成实验组和对照组，每组各54例，对照组采用激素和免疫抑制剂等常规治疗，实验组在对照组常规治疗的基础上加用了低分子肝素，分析对比两组患者的临床治疗有效率和不良反应等情况。结果对照组的治疗有效率为79.63%，实验组的治疗有效率为94.44%，实验组的治疗有效率明显高于对照组，并且差异有统计学意义(P<0.05)；实验组和对照组的治疗均能改善患儿ATPP、PT、FIB和D-D的状况，但实验组的改善程度较对照组更为显著(P<0.05)；对照组有5例患儿在皮下药物注射部位出现淤血，而实验组患儿无任何不良反应。结论低分子肝素在治疗小儿肾病综合征上临床疗效好，且能显著改善患儿的凝血功能，安全可靠，值得临床广泛推广使用。
目的：探究分析低分子肝素在小兒腎病綜閤徵中的臨床療效及其治療的安全性。方法採用迴顧性分析的方法，分析瞭該院兒科在2013年1月—2014年1月間收治的108例腎病綜閤徵的患兒的臨床資料。根據治療藥物的不同，將108例患兒隨機分成實驗組和對照組，每組各54例，對照組採用激素和免疫抑製劑等常規治療，實驗組在對照組常規治療的基礎上加用瞭低分子肝素，分析對比兩組患者的臨床治療有效率和不良反應等情況。結果對照組的治療有效率為79.63%，實驗組的治療有效率為94.44%，實驗組的治療有效率明顯高于對照組，併且差異有統計學意義(P<0.05)；實驗組和對照組的治療均能改善患兒ATPP、PT、FIB和D-D的狀況，但實驗組的改善程度較對照組更為顯著(P<0.05)；對照組有5例患兒在皮下藥物註射部位齣現淤血，而實驗組患兒無任何不良反應。結論低分子肝素在治療小兒腎病綜閤徵上臨床療效好，且能顯著改善患兒的凝血功能，安全可靠，值得臨床廣汎推廣使用。
목적：탐구분석저분자간소재소인신병종합정중적림상료효급기치료적안전성。방법채용회고성분석적방법，분석료해원인과재2013년1월—2014년1월간수치적108례신병종합정적환인적림상자료。근거치료약물적불동，장108례환인수궤분성실험조화대조조，매조각54례，대조조채용격소화면역억제제등상규치료，실험조재대조조상규치료적기출상가용료저분자간소，분석대비량조환자적림상치료유효솔화불량반응등정황。결과대조조적치료유효솔위79.63%，실험조적치료유효솔위94.44%，실험조적치료유효솔명현고우대조조，병차차이유통계학의의(P<0.05)；실험조화대조조적치료균능개선환인ATPP、PT、FIB화D-D적상황，단실험조적개선정도교대조조경위현저(P<0.05)；대조조유5례환인재피하약물주사부위출현어혈，이실험조환인무임하불량반응。결론저분자간소재치료소인신병종합정상림상료효호，차능현저개선환인적응혈공능，안전가고，치득림상엄범추엄사용。
Objective To explore and analyze the clinical effect and safety of low molecular weight heparin in children with nephrotic syndrome.Methods Retrospective analysis was applied, analyzed the pediatric department of our hospital from January 2013 to January 2014 were treated 108 cases of nephrotic syndrome in children. According to the different drug treatment, 108 patients were randomly divided into experimental group and control group, 54 cases in each group, the control group were given hormones and immune inhibitors and other conventional treatment, the experimental group based on the control group were given routine treatment combined with low molecular heparin, analyzed and compared the effective rate of clinical treatment and adverse reaction etc of the two groups.Results The effective rate of the treatment of control group was 79.63%, the effective rate of the treatment of the experimental group was 94.44%, the effective rate of treatment of experimental group was higher than that of control group, and the difference was statistically significant(P<0.05); the treatment of the experimental group and the control group were able to improve the children with ATPP, PT, FIB and D-D, but the degree of improvement the experimental group compared with the control group was significant(P<0.05); the control group had 5 cases occurred in children with congestion in the subcutaneous injection sites, while the experimental group patients without any adverse reaction.Conclusion Low molecular weight heparin in the treatment of children with nephrotic syndrome clinical curative effect is good, and can significantly improve the function of blood coagulation in children, less adverse reaction, safe and reliable, which is worthy of clinical widely used.
