中国当代医药
中國噹代醫藥
중국당대의약
PERSON
2015年
14期
100-101,104
,共3页
鼓膜修补术%重组表皮生长因子%莫匹罗星%应用效果
鼓膜脩補術%重組錶皮生長因子%莫匹囉星%應用效果
고막수보술%중조표피생장인자%막필라성%응용효과
Myringoplasty%Recombinant epidermal growth factor (REGF)%Mupirocin%Application effect
目的：探讨重组表皮生长因子联合莫匹罗星在鼓膜修补术中的临床应用效果。方法选择2013年1~12月在本院接受鼓膜修补术治疗的60例患者为研究对象，随机分为2组，各30例，对照组患者行明胶海绵单纯外贴手术，试验组患者行涂有重组表皮生长因子+莫匹罗星混合物的明胶海绵外贴手术，比较两组治疗效果及并发症情况。结果试验组治愈率为93.33%，对照组治愈率为86.67%，两组比较，差异无统计学意义(P跃0.05)；试验组并发症发生率为3.3%，低于对照组的20%，差异有统计学意义(P<0.05)；两组术后听力改善及鼓膜愈合时间比较，差异有统计学意义(P<0.05)。结论鼓膜修补术中应用重组表皮生长因子联合莫匹罗星，能有效促进创面愈合，减少并发症，提高手术成功率。
目的：探討重組錶皮生長因子聯閤莫匹囉星在鼓膜脩補術中的臨床應用效果。方法選擇2013年1~12月在本院接受鼓膜脩補術治療的60例患者為研究對象，隨機分為2組，各30例，對照組患者行明膠海綿單純外貼手術，試驗組患者行塗有重組錶皮生長因子+莫匹囉星混閤物的明膠海綿外貼手術，比較兩組治療效果及併髮癥情況。結果試驗組治愈率為93.33%，對照組治愈率為86.67%，兩組比較，差異無統計學意義(P躍0.05)；試驗組併髮癥髮生率為3.3%，低于對照組的20%，差異有統計學意義(P<0.05)；兩組術後聽力改善及鼓膜愈閤時間比較，差異有統計學意義(P<0.05)。結論鼓膜脩補術中應用重組錶皮生長因子聯閤莫匹囉星，能有效促進創麵愈閤，減少併髮癥，提高手術成功率。
목적：탐토중조표피생장인자연합막필라성재고막수보술중적림상응용효과。방법선택2013년1~12월재본원접수고막수보술치료적60례환자위연구대상，수궤분위2조，각30례，대조조환자행명효해면단순외첩수술，시험조환자행도유중조표피생장인자+막필라성혼합물적명효해면외첩수술，비교량조치료효과급병발증정황。결과시험조치유솔위93.33%，대조조치유솔위86.67%，량조비교，차이무통계학의의(P약0.05)；시험조병발증발생솔위3.3%，저우대조조적20%，차이유통계학의의(P<0.05)；량조술후은력개선급고막유합시간비교，차이유통계학의의(P<0.05)。결론고막수보술중응용중조표피생장인자연합막필라성，능유효촉진창면유합，감소병발증，제고수술성공솔。
Objective To explore the clinical application effect of recombinant epidermal growth factor (REGF) com-bined with mupirocin in myringoplasty. Methods 60 patients accepted myringoplasty in our hospital from January to December in 2013 were selected as research objects.They were evenly divided into two groups in random.In control group, patients were treated by external application of gelatin sponge alone,while external application of gelatin sponge covered with REGF combined with mupirocin was adopted to experimental group.The therapeutic effect and complica-tions between two groups was compared respectively. Results The cure rate in experimental group was 93.33%,while in control group,the rate was 86.67%,with no statistical differenc (P>0.05).In experimental group,the incidence of compli-cation was 3.3%,while in control group,the rate was 20%,with statistical difference (P<0.05).In addition,there were sta-tistical differences in postoperative hearing improvement and healing time of tympanic membrane (P<0.05). Conclusion Recombinant endothelial growth factor combined with mupirocin in myringoplasty can effectively promote wound heal-ing and reduce complications and improve the surgical successful rate.
