中国当代医药
中國噹代醫藥
중국당대의약
PERSON
2015年
14期
128-131
,共4页
羟基乙酸%黄褐斑%不良反应
羥基乙痠%黃褐斑%不良反應
간기을산%황갈반%불량반응
Glycolic acid%Chloasma%Adverse reaction
目的：探讨羟基乙酸治疗黄褐斑的临床效果。方法选取2010年2月~2013年6月在本院就诊并治疗的56例黄褐斑患者作为研究对象,采用患处涂抹羟基乙酸进行治疗,每2周1次,4次为1个疗程,连续治疗2个疗程,比较治疗前后的MASI评分及治疗总有效率,同时观察不良反应发生情况。结果所有患者均完成2个疗程的治疗,第2个疗程后的总有效率显著高于第1个疗程,差异有统计学意义(P<0.01)。第1个疗程后的MASI评分显著低于治疗前,差异有统计学意义(P<0.01)。第2个疗程后的MASI评分显著低于第1个疗程后及治疗前,差异有统计学意义(P<0.01)。表皮型黄褐斑的总有效率为76.7%,显著高于混合型的38.5%,差异有统计学意义(P<0.01)。郁型黄褐斑的总有效率为75.0%,显著高于芋型的40.0%,差异有统计学意义(P<0.05)。所有患者治疗后均出现瘙痒、刺痛感,经对症处理后症状消失,未出现严重不良反应。结论羟基乙酸治疗黄褐斑安全有效,尤其是对于表皮型及Fitzpatrick-Pathak分型郁型黄褐斑效果显著,值得临床推广使用。
目的：探討羥基乙痠治療黃褐斑的臨床效果。方法選取2010年2月~2013年6月在本院就診併治療的56例黃褐斑患者作為研究對象,採用患處塗抹羥基乙痠進行治療,每2週1次,4次為1箇療程,連續治療2箇療程,比較治療前後的MASI評分及治療總有效率,同時觀察不良反應髮生情況。結果所有患者均完成2箇療程的治療,第2箇療程後的總有效率顯著高于第1箇療程,差異有統計學意義(P<0.01)。第1箇療程後的MASI評分顯著低于治療前,差異有統計學意義(P<0.01)。第2箇療程後的MASI評分顯著低于第1箇療程後及治療前,差異有統計學意義(P<0.01)。錶皮型黃褐斑的總有效率為76.7%,顯著高于混閤型的38.5%,差異有統計學意義(P<0.01)。鬱型黃褐斑的總有效率為75.0%,顯著高于芋型的40.0%,差異有統計學意義(P<0.05)。所有患者治療後均齣現瘙癢、刺痛感,經對癥處理後癥狀消失,未齣現嚴重不良反應。結論羥基乙痠治療黃褐斑安全有效,尤其是對于錶皮型及Fitzpatrick-Pathak分型鬱型黃褐斑效果顯著,值得臨床推廣使用。
목적：탐토간기을산치료황갈반적림상효과。방법선취2010년2월~2013년6월재본원취진병치료적56례황갈반환자작위연구대상,채용환처도말간기을산진행치료,매2주1차,4차위1개료정,련속치료2개료정,비교치료전후적MASI평분급치료총유효솔,동시관찰불량반응발생정황。결과소유환자균완성2개료정적치료,제2개료정후적총유효솔현저고우제1개료정,차이유통계학의의(P<0.01)。제1개료정후적MASI평분현저저우치료전,차이유통계학의의(P<0.01)。제2개료정후적MASI평분현저저우제1개료정후급치료전,차이유통계학의의(P<0.01)。표피형황갈반적총유효솔위76.7%,현저고우혼합형적38.5%,차이유통계학의의(P<0.01)。욱형황갈반적총유효솔위75.0%,현저고우우형적40.0%,차이유통계학의의(P<0.05)。소유환자치료후균출현소양、자통감,경대증처리후증상소실,미출현엄중불량반응。결론간기을산치료황갈반안전유효,우기시대우표피형급Fitzpatrick-Pathak분형욱형황갈반효과현저,치득림상추엄사용。
Objective To explore the clinical effect of glycolic acid in the treatment of chloasma. Methods 56 patients with chloasma in our hospital from February 2010 to June 2013 were selected as the research object.Glycolic acid was used for covering on the affected part once every two weeks.One course of treatment contained 4 times and the treat-ment last two courses of treatment.The scores of melasma area and severity index (MASI),the total therapeutic effective rate before and after treatment was compared.At the same time,the occurrence of adverse reaction was observed. Results All participants were persisted on two courses of treatment.The total effective rate at the termination of the second course was higher than that in the first course,with significant difference (P<0.01).The scores of MASI at the termination of the first course was lower than that before treatment,with significant difference(P<0.01).The scores of MASI at the termina-tion of the second course was lower than that in the first course and before treatment,with significant difference (P<0.01).The total effective rate of chloasma in epidermal type was 76.7%,which was higher than 38.5%in mixed type,with significant difference (P<0.01).The total effective in typeⅣ chloasma was 75.0%,which was higher than 40.0% in typeⅢ,with significant difference (P<0.05). There were symptoms like skin itching and pricking in all patients after treat-ment,but which were both disappeared after symptomatic treatment.There was no severe adverse reaction occurred. Conclusion Glycolic acid is safe and effective in the treatment of chloasma,especially obtains better effect on epider-mal-type and type-Ⅳ chloasma based on Fitzpatrick-Pathak classification,it is worthy of clinical promotion and appli-cation.
