中国实用医药
中國實用醫藥
중국실용의약
CHINA PRACTICAL MEDICAL
2015年
18期
10-11,12
,共3页
不孕症%排卵障碍%坤泰胶囊%克罗米芬%人绒毛膜促性腺激素%疗效
不孕癥%排卵障礙%坤泰膠囊%剋囉米芬%人絨毛膜促性腺激素%療效
불잉증%배란장애%곤태효낭%극라미분%인융모막촉성선격소%료효
Infertility%Ovulation failure%Kuntai capsule%Clomiphene%Human chorionic gonadotropin%Curative effect
目的：探讨中成药坤泰胶囊对排卵障碍性不孕症患者卵泡发育、子宫内膜及排卵的影响。方法选取排卵障碍性不孕症患者210例,随机分成 A、B、C 三组,各70例。A 组口服坤泰胶囊, B组口服克罗米芬, C 组口服坤泰胶囊+克罗米芬,观察三组患者的卵泡大小、数目、子宫内膜厚度及类型。出现成熟卵泡再重新分组,Ⅰ组口服坤泰胶囊,直至排卵,Ⅱ组肌内注射人绒毛膜促性腺激素(HCG),观察两组患者排卵及卵泡黄素化情况。结果B、C 两组成熟卵泡数、排卵率均高于 A 组,差异具有统计学意义(P<0.01),但 B、C 组间比较,差异无统计学意义(P>0.05)。A、C 两组子宫内膜厚度及类型优于 B 组,差异有统计学意义(P<0.01),但 A、C 组间差异无统计学意义(P>0.05)。Ⅰ、Ⅱ两组血清雌二醇(E2)≥3000 pg/ml 的例数和排卵率,差异无统计学意义(P>0.05),Ⅰ组卵泡黄素化率明显小于Ⅱ组,差异有统计学意义(P<0.05)。结论坤泰胶囊对卵子发育成熟、改善子宫内膜容受性、卵子排出具有明显效果。
目的：探討中成藥坤泰膠囊對排卵障礙性不孕癥患者卵泡髮育、子宮內膜及排卵的影響。方法選取排卵障礙性不孕癥患者210例,隨機分成 A、B、C 三組,各70例。A 組口服坤泰膠囊, B組口服剋囉米芬, C 組口服坤泰膠囊+剋囉米芬,觀察三組患者的卵泡大小、數目、子宮內膜厚度及類型。齣現成熟卵泡再重新分組,Ⅰ組口服坤泰膠囊,直至排卵,Ⅱ組肌內註射人絨毛膜促性腺激素(HCG),觀察兩組患者排卵及卵泡黃素化情況。結果B、C 兩組成熟卵泡數、排卵率均高于 A 組,差異具有統計學意義(P<0.01),但 B、C 組間比較,差異無統計學意義(P>0.05)。A、C 兩組子宮內膜厚度及類型優于 B 組,差異有統計學意義(P<0.01),但 A、C 組間差異無統計學意義(P>0.05)。Ⅰ、Ⅱ兩組血清雌二醇(E2)≥3000 pg/ml 的例數和排卵率,差異無統計學意義(P>0.05),Ⅰ組卵泡黃素化率明顯小于Ⅱ組,差異有統計學意義(P<0.05)。結論坤泰膠囊對卵子髮育成熟、改善子宮內膜容受性、卵子排齣具有明顯效果。
목적：탐토중성약곤태효낭대배란장애성불잉증환자란포발육、자궁내막급배란적영향。방법선취배란장애성불잉증환자210례,수궤분성 A、B、C 삼조,각70례。A 조구복곤태효낭, B조구복극라미분, C 조구복곤태효낭+극라미분,관찰삼조환자적란포대소、수목、자궁내막후도급류형。출현성숙란포재중신분조,Ⅰ조구복곤태효낭,직지배란,Ⅱ조기내주사인융모막촉성선격소(HCG),관찰량조환자배란급란포황소화정황。결과B、C 량조성숙란포수、배란솔균고우 A 조,차이구유통계학의의(P<0.01),단 B、C 조간비교,차이무통계학의의(P>0.05)。A、C 량조자궁내막후도급류형우우 B 조,차이유통계학의의(P<0.01),단 A、C 조간차이무통계학의의(P>0.05)。Ⅰ、Ⅱ량조혈청자이순(E2)≥3000 pg/ml 적례수화배란솔,차이무통계학의의(P>0.05),Ⅰ조란포황소화솔명현소우Ⅱ조,차이유통계학의의(P<0.05)。결론곤태효낭대란자발육성숙、개선자궁내막용수성、란자배출구유명현효과。
Objective To investigate the influence of Chinese patent medicine Kuntai capsule on follicular development, endometrium and ovulation in ovulation failure infertility patients. Methods A total of 210 ovulation failure infertility patients were randomly divided into groups A, B and C, with 70 cases in each group. Group A received Kuntai capsule through oral administration, group B received clomiphene through oral administration, and group C received Kuntai capsule+clomiphene through oral administration. Size, number of follicular, thickness and type of endometrium were observed in the three groups. Patients with mature follicle were divided into new groups. Group Ⅰ received Kuntai capsule through oral administration till ovulation, and group Ⅱreceived human chorionic gonadotropin (HCG) through intramuscular injection. Ovulation and follicle luteinization were observed in the two groups. Results Groups B and C had higher mature follicle number and ovulation rate group A, and their difference had statistical significance (P<0.01), while the difference between group B and group C had no statistical significance (P>0.05). Groups A and C had better thickness and type of endometrium, and the difference had statistical significance (P<0.01), while the difference between group A and group C had no statistical significance (P>0.05). The difference of cases with serum estradiol (E2) ≥ 3000 pg/ml and ovulation rate between group Ⅰ and group Ⅱ had no statistical significance (P>0.05). Group Ⅰ had much lower follicle luteinization rate than group Ⅱ , and their difference had statistical significance (P<0.05). Conclusion Kuntai capsule provides obvious effects for ovum development, improving receptivity of endometrium and ovulation.
