CAJ | 학술논문

目前研究发现人类许多疾病与离子通道蛋白相关,故对于离子通道蛋白如何参与人类疾病的发展已成为各大学者的研究热点。 SLC26阴离子通道蛋白家族作为目前一类研究较多的离子通道蛋白,具有成员多、结构功能复杂多样等特点,可作为SO42-转运蛋白、阴离子交换器、阴离子通道蛋白等在组织上的特异性表达来发挥其功能,SLC26阴离子通道蛋白家族的表达及功能受多种机制调节,其家庭成员结构及功能变化与人类先天性营养不良、先天性氯化物腹泻、先天性耳聋及消化道疾病等多种人类疾病相关。本文就SLC26蛋白家族其结构功能、各家族成员及其主要功能、相关调节因素及其与相关疾病的关系等进行综述。
목전연구발현인류허다질병여리자통도단백상관,고대우리자통도단백여하삼여인류질병적발전이성위각대학자적연구열점。 SLC26음리자통도단백가족작위목전일류연구교다적리자통도단백,구유성원다、결구공능복잡다양등특점,가작위SO42-전운단백、음리자교환기、음리자통도단백등재조직상적특이성표체래발휘기공능,SLC26음리자통도단백가족적표체급공능수다충궤제조절,기가정성원결구급공능변화여인류선천성영양불량、선천성록화물복사、선천성이롱급소화도질병등다충인류질병상관。본문취SLC26단백가족기결구공능、각가족성원급기주요공능、상관조절인소급기여상관질병적관계등진행종술。
At present,the study found that many human diseases associated with a number of ion channel proteins,so the study of how an ion channel proteins involved in the development of human diseases channel has become a hot top-ic of major scholars.SLC26 anion channel protein family as a kind of research is currently more ion channel proteins, with the characteristics of more members and complicated structure and function,which can be used as SO42- trans-porters,anion exchanger,anion channel protein is specifically expressed in the tissue to exert its function,its expression and function by a variety of mechanisms regulating their family members,the structure and function of changes are as-sociated with a variety of human diseases for human congenital malnutrition,congenital chloride diarrhea,congenital deafness,digestive tract diseases,etc.This article makes a discussion on the SLC26 protein family in its structure and function, family members,and the main functions of related regulation and related disease relationship.