中国当代医药
中國噹代醫藥
중국당대의약
PERSON
2015年
14期
18-20
,共3页
Notch信号通路%结直肠肿瘤干细胞%结直肠癌%作用
Notch信號通路%結直腸腫瘤榦細胞%結直腸癌%作用
Notch신호통로%결직장종류간세포%결직장암%작용
Notch signaling pathway%Colorectal cancer stem cells%Colorectal cancer%Role
结直肠癌是消化系统中最常见的恶性肿瘤之一，有研究报道Notch信号通路在结直肠肿瘤干细胞形成结直肠癌中起关键作用，然而其对结直肠肿瘤干细胞的作用机制尚不清楚。如能清楚地了解Notch信号通路在结直肠肿瘤干细胞中的作用，可为以后研发以Notch信号通路联合肿瘤干细胞为治疗靶点的新途径提供参考。本研究就Notch信号通路在结直肠肿瘤干细胞中作用的相关文献加以综述。
結直腸癌是消化繫統中最常見的噁性腫瘤之一，有研究報道Notch信號通路在結直腸腫瘤榦細胞形成結直腸癌中起關鍵作用，然而其對結直腸腫瘤榦細胞的作用機製尚不清楚。如能清楚地瞭解Notch信號通路在結直腸腫瘤榦細胞中的作用，可為以後研髮以Notch信號通路聯閤腫瘤榦細胞為治療靶點的新途徑提供參攷。本研究就Notch信號通路在結直腸腫瘤榦細胞中作用的相關文獻加以綜述。
결직장암시소화계통중최상견적악성종류지일，유연구보도Notch신호통로재결직장종류간세포형성결직장암중기관건작용，연이기대결직장종류간세포적작용궤제상불청초。여능청초지료해Notch신호통로재결직장종류간세포중적작용，가위이후연발이Notch신호통로연합종류간세포위치료파점적신도경제공삼고。본연구취Notch신호통로재결직장종류간세포중작용적상관문헌가이종술。
Colorectal cancer is one of the most common tumors in the digestive system.The research has reported: col-orectal cancer stem cells have formed colorectal cancer because Notch signaling pathway has played a key effect on it. but it is not clear of the mechanism of colorectal cancer stem cells.If we can clearly understand what exactly the role Notch signal pathway plays,the effect can help us to open new ways for the future research and development through Notch signaling pathway joint methods of using cancer stem cells as therapeutic targets.In this paper,the literature relat-ed to the role of Notch signaling pathway in colorectal cancer stem cells is to be reviewed.
