CAJ | 학술논문

目的：研究降钙素原（PCT）联合C反应蛋白（CRP）、白细胞（WBC）诊断新生儿感染性肺炎的临床影响。方法：选取2012年7月～2014年7月我院收治的110例患有感染性肺炎的新生儿作为观察组，其中细菌性感染患儿55例，病毒性感染患儿55例，随机选取无任何感染性疾病的新生儿55例作为对照组，抽取静脉血诊断降钙素原、C反应蛋白、白细胞，观察并比较3组间的PCT、CBP、WBC水平。结果：观察组中细菌感染患儿的PCT水平（0.81±0.25）ng/ml，CRP水平（22.53±3.28）mg/L，WBC水平（16.86±2.63）×109/L，病毒性感染患儿的PCT水平（0.57±0.37）ng/ml，CRP水平（9.35±2.63）mg/L，WBC水平（10.51±2.45）×109/L，对照组中PCT水平（0.31±0.34）ng/ml，CRP水平（5.23±2.21）mg/L，WBC水平（6.53±2.41）×109/L。三组比较组间水平差异显著，具有统计学意义（P<0.05）；两两比较，细菌感染组水平高于病毒感染组与对照组患儿，差异显著，具有统计学意义（P<0.05）；且病毒感染组水平高于对照组，差异显著，具有统计学意义（P<0.05）。细菌感染组中：PCT敏感度为82.80%，特异度为91.40%，CRP敏感度为69.80%，特异度为46.30%，WBC敏感度为40.20%，特异度为34.60%；病毒感染组中：PCT敏感度为59.70%，特异度为71.60%，WBC敏感度为39.50%，特异度为31.30%，联合诊断敏感度为16.90%，特异度为21.40%。结论：采用降钙素原联合C反应蛋白、白细胞诊断新生儿感染性肺炎具有良好的敏感度、特异度，能有效帮助医生确切诊断细菌性感染或病毒性感染，在临床上值得推广应用。
목적：연구강개소원（PCT）연합C반응단백（CRP）、백세포（WBC）진단신생인감염성폐염적림상영향。방법：선취2012년7월～2014년7월아원수치적110례환유감염성폐염적신생인작위관찰조，기중세균성감염환인55례，병독성감염환인55례，수궤선취무임하감염성질병적신생인55례작위대조조，추취정맥혈진단강개소원、C반응단백、백세포，관찰병비교3조간적PCT、CBP、WBC수평。결과：관찰조중세균감염환인적PCT수평（0.81±0.25）ng/ml，CRP수평（22.53±3.28）mg/L，WBC수평（16.86±2.63）×109/L，병독성감염환인적PCT수평（0.57±0.37）ng/ml，CRP수평（9.35±2.63）mg/L，WBC수평（10.51±2.45）×109/L，대조조중PCT수평（0.31±0.34）ng/ml，CRP수평（5.23±2.21）mg/L，WBC수평（6.53±2.41）×109/L。삼조비교조간수평차이현저，구유통계학의의（P<0.05）；량량비교，세균감염조수평고우병독감염조여대조조환인，차이현저，구유통계학의의（P<0.05）；차병독감염조수평고우대조조，차이현저，구유통계학의의（P<0.05）。세균감염조중：PCT민감도위82.80%，특이도위91.40%，CRP민감도위69.80%，특이도위46.30%，WBC민감도위40.20%，특이도위34.60%；병독감염조중：PCT민감도위59.70%，특이도위71.60%，WBC민감도위39.50%，특이도위31.30%，연합진단민감도위16.90%，특이도위21.40%。결론：채용강개소원연합C반응단백、백세포진단신생인감염성폐염구유량호적민감도、특이도，능유효방조의생학절진단세균성감염혹병독성감염，재림상상치득추엄응용。
Objective: To study procalcitonin(PCT)combined with C-reactive protein(CBP), white blood cell(WBC) diagnosis of the clinical impact of neonatal pneumonia infection. Methods: Neonatal July 2012 to July 2014 in our hospital 110 cases of infection with pneumonia as the observation group, including 55 cases of children with bacterial infections, viral infections in children 55 cases randomly selected without any neonatal infectious disease as the control group 55 cases, extraction cubital vein diagnosis procalcitonin, C-reactive protein, white blood cells, were observed and compared among the three groups of PCT, CBP, WBC levels. Results: The PCT levels in children with bacterial infection(0.81±0.25)ng/ml, CRP levels(22.53±3.28)mg / L, WBC levels(16.86±2.63)×109/L, children with viral infections PCT levels(0.57±0.37)ng/ml, CRP levels(9.35±2.63)mg / L, WBC levels(10.51±2.45)×109/L, PCT levels in the control group(0.31±0.34)ng/ml, CRP levels(5.23±2.21)mg/L, WBC levels(6.53 ±2.41)×109/L. Group level among the three groups were significantly different, with statistical significance (P<0.05); pairwise comparison, bacterial infection group was higher than in childreninfected with the control group, the difference was significant, with statistical significance (P<0.05);and the viral infection level higher, the difference is remarkable, with a statistically significant (P<0.05). Bacterial infection group: PCT sensitivity of 82.80% and a specificity of 91.40%, CRP sensitivity of 69.80% and a specificity of 46.30%, WBC sensitivity of 40.20% and a specificity of 34.60%;virus group:PCT sensitivity of 59.70%and a specificity of 71.60%, WBC sensitivity of 39.50%and a specificity of 31.30%, 16.90%joint diagnostic sensitivity and specificity of 21.40%. Conclusion: The use of procalcitonin joint C-reactive protein, white blood cell diagnosis of neonatal pneumonia has good sensitivity, specificity, and can effectively help doctors diagnose the exact bacterial infection or viral infection, should be widely applied in clinical practice.