北方药学
北方藥學
북방약학
JOURNAL OF NORTH PHARMACY
2015年
6期
104-105
,共2页
小剂量%卡托普利%硝酸甘油%高血压急症%疗效
小劑量%卡託普利%硝痠甘油%高血壓急癥%療效
소제량%잡탁보리%초산감유%고혈압급증%료효
Small doses%Captopril%Nitroglycerin%Hypertensive emergency%Efficacy
目的：观察小剂量卡托普利联合硝酸甘油静滴治疗高血压急症的疗效。方法：将广东省怀集县人民医院急诊收治的高血压急症患者60例随机分为观察组与对照组，每组30例，对照组采用25mg卡托普利舌下含服联合硝酸甘油10ml葡萄糖溶液静脉滴注，观察组药物剂量为对照组的一半，比较治疗前及治疗后的收缩压（SBP）、舒张压（DBP）、平均动脉压（MAP）水平及不良反应情况。结果：两组治疗10min、15min、30min及1h的SBP、DBP及MAP水平均显著低于治疗前，P<0.001；观察组治疗10min、治疗15min、治疗30mim及治疗1h的SBP、DBP及MAP水平均显著高于对照组，P<0.05；观察组治疗1h后的MAP平均降低幅度为22.1%，对照组为30.5%；观察组降压幅度在高血压急症指南推荐范围内（治疗1h内MAP平均降低幅度不超过25%）；两组患者治疗1h内咳嗽、皮疹、心率加快及血压过低等并发症比较差异无统计学意义；观察组总并发症（16.7%vs 43.3%）显著低于对照组，P<0.05。结论：小剂量卡托普利联合硝酸甘油静滴治疗高血压急症可有效降低血压，降压更为平稳，总并发症相对较少，值得临床推广。
目的：觀察小劑量卡託普利聯閤硝痠甘油靜滴治療高血壓急癥的療效。方法：將廣東省懷集縣人民醫院急診收治的高血壓急癥患者60例隨機分為觀察組與對照組，每組30例，對照組採用25mg卡託普利舌下含服聯閤硝痠甘油10ml葡萄糖溶液靜脈滴註，觀察組藥物劑量為對照組的一半，比較治療前及治療後的收縮壓（SBP）、舒張壓（DBP）、平均動脈壓（MAP）水平及不良反應情況。結果：兩組治療10min、15min、30min及1h的SBP、DBP及MAP水平均顯著低于治療前，P<0.001；觀察組治療10min、治療15min、治療30mim及治療1h的SBP、DBP及MAP水平均顯著高于對照組，P<0.05；觀察組治療1h後的MAP平均降低幅度為22.1%，對照組為30.5%；觀察組降壓幅度在高血壓急癥指南推薦範圍內（治療1h內MAP平均降低幅度不超過25%）；兩組患者治療1h內咳嗽、皮疹、心率加快及血壓過低等併髮癥比較差異無統計學意義；觀察組總併髮癥（16.7%vs 43.3%）顯著低于對照組，P<0.05。結論：小劑量卡託普利聯閤硝痠甘油靜滴治療高血壓急癥可有效降低血壓，降壓更為平穩，總併髮癥相對較少，值得臨床推廣。
목적：관찰소제량잡탁보리연합초산감유정적치료고혈압급증적료효。방법：장광동성부집현인민의원급진수치적고혈압급증환자60례수궤분위관찰조여대조조，매조30례，대조조채용25mg잡탁보리설하함복연합초산감유10ml포도당용액정맥적주，관찰조약물제량위대조조적일반，비교치료전급치료후적수축압（SBP）、서장압（DBP）、평균동맥압（MAP）수평급불량반응정황。결과：량조치료10min、15min、30min급1h적SBP、DBP급MAP수평균현저저우치료전，P<0.001；관찰조치료10min、치료15min、치료30mim급치료1h적SBP、DBP급MAP수평균현저고우대조조，P<0.05；관찰조치료1h후적MAP평균강저폭도위22.1%，대조조위30.5%；관찰조강압폭도재고혈압급증지남추천범위내（치료1h내MAP평균강저폭도불초과25%）；량조환자치료1h내해수、피진、심솔가쾌급혈압과저등병발증비교차이무통계학의의；관찰조총병발증（16.7%vs 43.3%）현저저우대조조，P<0.05。결론：소제량잡탁보리연합초산감유정적치료고혈압급증가유효강저혈압，강압경위평은，총병발증상대교소，치득림상추엄。
Objective to explore the efficacy of Small doses captopril combined nitroglycerin treated for hypertensive emergencies. Methods 60 patients with hypertensive emergencies from emergency department of huaiji coounty peopl's hospital were randomly divided into the observation group and the control group.each group contain 30 cases.the control group treated with 25 mg captopril combined 10ml nitroglycerin glucose solution intravenously.the observation treated with the same medical,the Dose for half of the control group.the ystolic blood pressure(SBP), diastolic blood pressure(DBP), mean arterial pressure(MAP) levels and adverse reactions were compared before and after treatment. Results the SBP, DBP, and MAP level at the first 10min, 15min, 30min and 1h were significantly lower than before treatment, P<0.001.the SBP, DBP and MAP level at the first 10min, 15min, 30min and 1h in the observation group was significantly higher than that in the control group. P<0.05. The average magnitude lower of MAP in the observation group was 22.1%.and that was 30.5% in the control group.the average magnitude lower of MAP in the observation group was in the hypertensive emergency guidelines recommend range.(1h MAP reduce the therapeutic margin of no more than 25%).the Cough, rash, rapid heart rate and low blood pressure rate in the two groups were compared with no significant difference.the total complications(16.7%vs 43.3%)in the observation group was significantly lower than the control group P<0.05. Conclusions Low-dose captopril combined nitroglycerin therapy can effectively lower blood pressure .the hypertensive emergency water products, and more stable blood pressure, total complications relatively less worthy applications. buck is more stable,the total complications is fewer. it is worth applications.
