CAJ | 학술논문

目的：探究胱抑素C（Cys-C）与老年人高血压靶器官损害的关系。方法：选择来我院就诊确诊为老年人高血压合并靶器官损害（TOD）的患者60例作为分析组，老年高血压未合并靶器官损害的患者60例为对照组，挑选60例身体健康的老年人作为健康组；空腹状态下静脉采血，并使用免疫比浊法对各组患者的胱抑素C水平进行测定，同时检测血肌酐、尿微量白蛋白，经超声图像对左心室质量指数（LVMI）进行评估，探究胱抑素C与各项生理指标的相关性。结果：分析组、对照组和健康组Cys-C水平分别达到（1.84±0.32）mg/L、（0.92±0.36）mg/L和（0.85±0.34）mg/L，分析组血清Cys-C水平明显高于对照组和健康组（F=88.43，P=0.000），而对照组与健康组体内Cys-C水平比较差异并无统计学意义（P>0．05）。年龄因素经偏回归分析剔除，可以看出分析组血清Cys-C水平与血肌酐、尿微量白蛋白、左心室质量指数呈正相关（r-0.420、0.526、0.470，P-0.021、0.019、0.034）。结论：血清Cys-C水平在老年人高血压靶器官损害患者体内明显升高，且与血肌酐、尿微量白蛋白及左心室质量指数呈正相关，血清Cys-C水平可在评估老年人高血压靶器官损害时作为重要指标之一。
목적：탐구광억소C（Cys-C）여노년인고혈압파기관손해적관계。방법：선택래아원취진학진위노년인고혈압합병파기관손해（TOD）적환자60례작위분석조，노년고혈압미합병파기관손해적환자60례위대조조，도선60례신체건강적노년인작위건강조；공복상태하정맥채혈，병사용면역비탁법대각조환자적광억소C수평진행측정，동시검측혈기항、뇨미량백단백，경초성도상대좌심실질량지수（LVMI）진행평고，탐구광억소C여각항생리지표적상관성。결과：분석조、대조조화건강조Cys-C수평분별체도（1.84±0.32）mg/L、（0.92±0.36）mg/L화（0.85±0.34）mg/L，분석조혈청Cys-C수평명현고우대조조화건강조（F=88.43，P=0.000），이대조조여건강조체내Cys-C수평비교차이병무통계학의의（P>0．05）。년령인소경편회귀분석척제，가이간출분석조혈청Cys-C수평여혈기항、뇨미량백단백、좌심실질량지수정정상관（r-0.420、0.526、0.470，P-0.021、0.019、0.034）。결론：혈청Cys-C수평재노년인고혈압파기관손해환자체내명현승고，차여혈기항、뇨미량백단백급좌심실질량지수정정상관，혈청Cys-C수평가재평고노년인고혈압파기관손해시작위중요지표지일。
Objective:To explore the relationship between serum cystatin C(Cys-C) and senile hypertension target organ damage and to guide clinical significance. Methods: our hospital diagnosed with target organ damage in elderly essential hypertension (TOD) of sixty patients cases as the analysis group, sixty cases of senile hypertension does not merge the target organ damage in patients as control group, then the corresponding selected sixty cases of healthy elderly people as healthy group, the fasting state, venous blood turbidimetric method, and for each group of patients with cystatin C levels were measured using immune, and simultaneous detection of serum creatinine, urinary album in, the ultrasound image of the left ventricular mass index (LVMI) to assess the correlation between cystatin C, inquiry and various physiological indexes. Results:the analysis group, control group and healthy group Cys-C levels were hit (1.84±0.32) mg/L, (0.92±0.36) mg/L and (0.85±0.34) mg/L, analysis of serum level of Cys-C group was higher than that of the control group and the healthy group (F=88.43, P=0.000), while the control group and the health group differences in the level of Cys-C in there was no statistical significance (P>0.05). The age factor according to the regression analyses excluded, can see analysis groups of patients with serum Cys-C level and serum creatinine, urinary albumin, left ventricular mass index were positively correlated (r-0.420, P-0.021,0.526,0.470,0.019,0.034). Conclusion:the serum level of Cys-C in the target organ damage in elderly patients with hypertension in vivo increased significantly, and serum creatinine, urinary albumin and left ventricular mass index were positively correlated, the serum level of Cys-C may be one of important index in elderly hypertensive patients with target organ damage assessment at.