中华核医学与分子影像杂志
中華覈醫學與分子影像雜誌
중화핵의학여분자영상잡지
Chinese Journal of Nuclear Medicine and Molecular Imaging
2015年
2期
92-96
,共5页
吴冰%石洪成%陈曙光%顾宇参
吳冰%石洪成%陳曙光%顧宇參
오빙%석홍성%진서광%고우삼
胰腺肿瘤%体层摄影术,发射型计算机%体层摄影术,X线计算机%脱氧葡萄糖
胰腺腫瘤%體層攝影術,髮射型計算機%體層攝影術,X線計算機%脫氧葡萄糖
이선종류%체층섭영술,발사형계산궤%체층섭영술,X선계산궤%탈양포도당
Pancreatic neoplasms%Tomography,emission-computed%Tomography,X-ray computed%Deoxyglucose
目的 探讨18F-FDG PET/CT显像在胰腺肿瘤诊断中的应用价值.方法 回顾性分析53例临床疑似胰腺肿瘤患者[男36例,女17例,年龄(60.3±8.9)岁]的18F-FDG PET/CT影像资料及血清CA19-9结果,其中32例患者行双时相显像.以病理结果为“金标准”,评价18F-FDG PET/CT诊断胰腺肿瘤的价值.采用两样本t检验、配对t检验和ROC曲线分析处理数据.结果 53例中,恶性39例,良性14例.ROC曲线示,常规显像以SUVmax3.13为判断肿瘤良恶性的界值时,诊断效能最高,灵敏度及特异性分别为92.3% (36/39)及9/14.恶性肿瘤组SUVmax(6.16±2.89)较良性病变组高(3.37±1.58;t=4.46,P<0.01).常规显像结合血清CA19-9水平诊断的灵敏度及特异性分别为69.2%(27/39)及13/14.双时相显像时,恶性肿瘤组(23例)早期及延迟SUVmax差异有统计学意义(5.45±2.43和6.87±2.93;t=8.25,P<0.01),而良性病变组(9例)的差异则不具有统计学意义(3.18±1.28和4.18±2.49;t=2.24,P>0.05).2组间早期相和延迟相的SUVmax差异均有统计学意义(早期相:t=3.43;延迟相:t=2.58;均P<0.05).早期相取SUVmax 3.3为界值时的诊断效能最高,灵敏度、特异性及准确性分别为87.0% (20/23)、6/9及81.2% (26/32);延迟相取SUVmax 3.0为界值时的诊断效能最高,指标分别为95.7%(22/23)、5/9及84.4% (27/32).结论 18F-FDG PET/CT是一种较好的胰腺良恶性病变鉴别方法.
目的 探討18F-FDG PET/CT顯像在胰腺腫瘤診斷中的應用價值.方法 迴顧性分析53例臨床疑似胰腺腫瘤患者[男36例,女17例,年齡(60.3±8.9)歲]的18F-FDG PET/CT影像資料及血清CA19-9結果,其中32例患者行雙時相顯像.以病理結果為“金標準”,評價18F-FDG PET/CT診斷胰腺腫瘤的價值.採用兩樣本t檢驗、配對t檢驗和ROC麯線分析處理數據.結果 53例中,噁性39例,良性14例.ROC麯線示,常規顯像以SUVmax3.13為判斷腫瘤良噁性的界值時,診斷效能最高,靈敏度及特異性分彆為92.3% (36/39)及9/14.噁性腫瘤組SUVmax(6.16±2.89)較良性病變組高(3.37±1.58;t=4.46,P<0.01).常規顯像結閤血清CA19-9水平診斷的靈敏度及特異性分彆為69.2%(27/39)及13/14.雙時相顯像時,噁性腫瘤組(23例)早期及延遲SUVmax差異有統計學意義(5.45±2.43和6.87±2.93;t=8.25,P<0.01),而良性病變組(9例)的差異則不具有統計學意義(3.18±1.28和4.18±2.49;t=2.24,P>0.05).2組間早期相和延遲相的SUVmax差異均有統計學意義(早期相:t=3.43;延遲相:t=2.58;均P<0.05).早期相取SUVmax 3.3為界值時的診斷效能最高,靈敏度、特異性及準確性分彆為87.0% (20/23)、6/9及81.2% (26/32);延遲相取SUVmax 3.0為界值時的診斷效能最高,指標分彆為95.7%(22/23)、5/9及84.4% (27/32).結論 18F-FDG PET/CT是一種較好的胰腺良噁性病變鑒彆方法.
목적 탐토18F-FDG PET/CT현상재이선종류진단중적응용개치.방법 회고성분석53례림상의사이선종류환자[남36례,녀17례,년령(60.3±8.9)세]적18F-FDG PET/CT영상자료급혈청CA19-9결과,기중32례환자행쌍시상현상.이병리결과위“금표준”,평개18F-FDG PET/CT진단이선종류적개치.채용량양본t검험、배대t검험화ROC곡선분석처리수거.결과 53례중,악성39례,량성14례.ROC곡선시,상규현상이SUVmax3.13위판단종류량악성적계치시,진단효능최고,령민도급특이성분별위92.3% (36/39)급9/14.악성종류조SUVmax(6.16±2.89)교량성병변조고(3.37±1.58;t=4.46,P<0.01).상규현상결합혈청CA19-9수평진단적령민도급특이성분별위69.2%(27/39)급13/14.쌍시상현상시,악성종류조(23례)조기급연지SUVmax차이유통계학의의(5.45±2.43화6.87±2.93;t=8.25,P<0.01),이량성병변조(9례)적차이칙불구유통계학의의(3.18±1.28화4.18±2.49;t=2.24,P>0.05).2조간조기상화연지상적SUVmax차이균유통계학의의(조기상:t=3.43;연지상:t=2.58;균P<0.05).조기상취SUVmax 3.3위계치시적진단효능최고,령민도、특이성급준학성분별위87.0% (20/23)、6/9급81.2% (26/32);연지상취SUVmax 3.0위계치시적진단효능최고,지표분별위95.7%(22/23)、5/9급84.4% (27/32).결론 18F-FDG PET/CT시일충교호적이선량악성병변감별방법.
Objective To evaluate the diagnostic value of 18F-FDG PET/CT in patients with pancreatic neoplasm.Methods Fifty-three patients (36 males,17 females; age:(60.3±8.9) years) who underwent 18F-FDG PET/CT examination for suspected pancreatic tumor were retrospectively analyzed.Thirtytwo of them underwent dual-time point imaging.The characteristics of PET/CT images and serum CA19-9 were reviewed.Pathological results were used as a gold standard for evaluating the diagnostic value of PET/CT.Two-sample t test,paired t test and ROC curve analysis were used for data analysis.Results Thirtynine patients were finally diagnosed with pancreatic cancer and the other fourteen patients with benign disease.With SUVmax cutoff value of 3.13,the sensitivity and specificity of single-time point 18F-FDG PET/CT for diagnosis of pancreatic cancer were 92.3% (36/39) and 9/14,respectively.The SUVmax was significant different between pancreatic cancer group and benign disease group (6.16±2.89 vs 3.37± 1.58; t =4.46,P<0.01).Combined with the level of CA19-9,the diagnostic sensitivity and specificity were 69.2% (27/39)and 13/14,respectively.The SUVmax of the early scan (5.45±2.43) was significantly different from that of the delayed scan (6.87±2.93) in pancreatic cancer group (t =8.25,P<0.01),whereas no difference could be found in the benign group (3.18±1.28 vs 4.18±2.49; t=2.24,P>0.05).With the SUVmax cutoff value of 3.3,the sensitivity,specificity and accuracy in the early scan were 87.0% (20/23),6/9 and 81.2% (26/32),respectively.While with the SUVmax cutoff value of 3.0,the sensitivity,specificity and accuracy in the delayed scan were 95.7% (22/23),5/9 and 84.4% (27/32),respectively.Conclusion 18 F-FDG PET/CT is a useful tool in the differential diagnosis of benign from malignant pancreatic diseases.