CAJ | 학술논문

目的：确定吡格列酮/二甲双胍缓释片处方及制备工艺。方法分别以释放度及溶出度为指标对二甲双胍缓释骨架层及吡格列酮速释层进行处方和工艺研究，并对吡格列酮/二甲双胍缓释片的释放度进行考察。结果吡格列酮/二甲双胍缓释片缓释层体外释放行为与模型药物Glucophage XR（格华止）相似，速释层吡格列酮与模型药物Actos（艾可拓）体外溶出行为不相似，但30 min累计溶出药物总量相似。结论所制备的吡格列酮/二甲双胍缓释片处方组成合理，工艺可行。
목적：학정필격렬동/이갑쌍고완석편처방급제비공예。방법분별이석방도급용출도위지표대이갑쌍고완석골가층급필격렬동속석층진행처방화공예연구，병대필격렬동/이갑쌍고완석편적석방도진행고찰。결과필격렬동/이갑쌍고완석편완석층체외석방행위여모형약물Glucophage XR（격화지）상사，속석층필격렬동여모형약물Actos（애가탁）체외용출행위불상사，단30 min루계용출약물총량상사。결론소제비적필격렬동/이갑쌍고완석편처방조성합리，공예가행。
Objective To ascertain the formulation and preparation of Pioglitazone/Metformin Sustained-release Tab-lets. Methods The releasing rate and dissolution rate were used as indicators to investigate the formulation and preparation of metformin layer as well as pioglitazone layer,and to investigate the releasing rate of Pioglitazone/Metformin Sustained-release Tablets. Results The release behavior in vitro of sustained release layer was resemble to Glucophage XR. Though the behavior of quick release layer wasn′t resemble to the model drug,the cumulative amount of dissolution of 30 min was similar. Conclusion The formulation of Pioglitazone/Metformin Sustained-release Tablets were feasible,and the process was reasonable.