中医药学报
中醫藥學報
중의약학보
ACTA CHINESE MEDICINE AND PHARMACOLOGY
2015年
3期
42-44
,共3页
耿广琴%杨志军%杨秀娟%李晶
耿廣琴%楊誌軍%楊秀娟%李晶
경엄금%양지군%양수연%리정
黄芩%肝损伤模型%SOD活性%MDA含量%组织结构变化%比较研究
黃芩%肝損傷模型%SOD活性%MDA含量%組織結構變化%比較研究
황금%간손상모형%SOD활성%MDA함량%조직결구변화%비교연구
Scutellaria baicalensis Georgi%Liver injury model%SOD activities%MDA level%Structural changes%Compara-tive study
目的:探讨甘肃产黄芩与河北承德产道地黄芩保肝作用的差异。方法:腹腔注射0.1% CCl4建立小鼠急性肝损伤模型,检测肝组织SOD活性、MDA含量,观察肝组织结构损伤。结果:甘肃产黄芩与道地黄芩高剂量组均能增强CCl4致肝损伤小鼠肝组织SOD活力,降低MDA含量(P<0.01),明显改善肝组织病变。结论:甘肃产黄芩与道地黄芩均有显著的保肝作用,同剂量道地黄芩保肝功效略优于甘肃陇西产黄芩,但二者之间差异不显著。
目的:探討甘肅產黃芩與河北承德產道地黃芩保肝作用的差異。方法:腹腔註射0.1% CCl4建立小鼠急性肝損傷模型,檢測肝組織SOD活性、MDA含量,觀察肝組織結構損傷。結果:甘肅產黃芩與道地黃芩高劑量組均能增彊CCl4緻肝損傷小鼠肝組織SOD活力,降低MDA含量(P<0.01),明顯改善肝組織病變。結論:甘肅產黃芩與道地黃芩均有顯著的保肝作用,同劑量道地黃芩保肝功效略優于甘肅隴西產黃芩,但二者之間差異不顯著。
목적:탐토감숙산황금여하북승덕산도지황금보간작용적차이。방법:복강주사0.1% CCl4건립소서급성간손상모형,검측간조직SOD활성、MDA함량,관찰간조직결구손상。결과:감숙산황금여도지황금고제량조균능증강CCl4치간손상소서간조직SOD활력,강저MDA함량(P<0.01),명현개선간조직병변。결론:감숙산황금여도지황금균유현저적보간작용,동제량도지황금보간공효략우우감숙롱서산황금,단이자지간차이불현저。
Objective:The article was to explore the differences of protective effects on hepar by Scutellaria baicalensis Georgi from Longxi of Gansu province and Chengde of Hebei province.Methods:The mice were injected by intraperito-neal injection with 0.1%CCl4 olive oil to induce the acute liver injury models.The liver tissues were collected to detect SOD activities and MDA levels,and the morphological changes of liver were observed with microscope.Results:SOD ac-tivities were both elevated obviously and MDA levels were notably reduced in hepatic tissue after the mice were given by Scutellaria baicalensis Georgi with high dose( P<0.01) .The damage of liver was lightened as well.Conclusion:Scute-llaria baicalensis Georgi from both places has the liver protective effect.The liver-protective effect in the equilibrium dose of Scutellaria baicalensis Georgi from Hebei was slightly better than that from Gansu.There is no significant differ-ence.