CAJ | 학술논문

目的：通过拟血管性痴呆大鼠模型的给药治疗，探究新药醒脑胶囊对VD大鼠脑内谷胱甘肽过氧化物酶（ GSH－PX ）和乙酰胆碱酯酶（ AchE）活性以及学习记忆行为的影响和治疗机制。方法：将81只健康纯系Wistar老年大鼠随机分组：假手术组、模型组、中药组和西药对照组，然后利用2－血管阻断法（2－VO）制作VD大鼠模型。其中，中药组VD大鼠灌服醒脑胶囊蒸馏水混悬液。对VD大鼠治疗前后脑组织内GSH－PX和AchE活性的改变以及穿梭箱行动能力测试结果进行比照分析。结果：统计分析表明，醒脑胶囊可有效增强VD大鼠脑组织中GSH－PX的活性，有效降低脑组织中AchE活性，同时明显减少穿梭箱实验过程中VD大鼠的电击次数和电击时间。结论：治疗后的VD大鼠记忆学习能力明显改善，GSH－PX活性得到提高，而AchE活性降低，表明醒脑胶囊能改善VD的痴呆程度，促进VD大鼠的智能恢复。
목적：통과의혈관성치태대서모형적급약치료，탐구신약성뇌효낭대VD대서뇌내곡광감태과양화물매（ GSH－PX ）화을선담감지매（ AchE）활성이급학습기억행위적영향화치료궤제。방법：장81지건강순계Wistar노년대서수궤분조：가수술조、모형조、중약조화서약대조조，연후이용2－혈관조단법（2－VO）제작VD대서모형。기중，중약조VD대서관복성뇌효낭증류수혼현액。대VD대서치료전후뇌조직내GSH－PX화AchE활성적개변이급천사상행동능력측시결과진행비조분석。결과：통계분석표명，성뇌효낭가유효증강VD대서뇌조직중GSH－PX적활성，유효강저뇌조직중AchE활성，동시명현감소천사상실험과정중VD대서적전격차수화전격시간。결론：치료후적VD대서기억학습능력명현개선，GSH－PX활성득도제고，이AchE활성강저，표명성뇌효낭능개선VD적치태정도，촉진VD대서적지능회복。
Objective:To study the effect of Xingnao capsules on the activity of GSH-PX and AchE for learning dysmne-sia of VD rats.Methods:Select 81 healthy Wistar rats and they were divided into 4 groups.They were negative injury group, model group, Chinese medicine group and relative group.In the experiment, we adopted 2-VD to duplicate VD models and had rats taken aqueous solution of Xingnao capsules.By the end of the study, we examined the memory abil-ity of rats according to the shuttle test.Results:Xingnao capsules could promote the activities of GSH-PX and diminish the activities of AchE.Conclusion:Xingnao capsules could improve the learning and memory ability of models and pro-mote the activities of GSH-PX and decrease the activities of AchE.And it can promote the restoring function of injured neuron.