CAJ | 학술논문

目的：测定人肝微粒体中去氢骆驼蓬碱的代谢产物。方法：以去氢骆驼蓬碱为研究对象，采用高效液相色谱－离子阱－质谱系统分析去氢骆驼蓬碱经肝微粒体代谢的代谢产物。结果：去氢骆驼蓬碱在人肝微粒体中经Ⅰ相代谢后产物主要为哈尔酚。结论：哈尔酚为首次报道的代谢产物，本研究利用液质联用技术阐明了去氢骆驼蓬碱的体内代谢产物，为进一步研究奠定了基础。
목적：측정인간미립체중거경락타봉감적대사산물。방법：이거경락타봉감위연구대상，채용고효액상색보－리자정－질보계통분석거경락타봉감경간미립체대사적대사산물。결과：거경락타봉감재인간미립체중경Ⅰ상대사후산물주요위합이분。결론：합이분위수차보도적대사산물，본연구이용액질련용기술천명료거경락타봉감적체내대사산물，위진일보연구전정료기출。
Objective:To determine the metabolism of Harmine in human liver microsome.Methods:The metabolites of Harmine in human liver microsome as the research objects were analyzed by HPLC-Trap-MS.Results:The main me-tabolite of Harmine in human liver microsome by phase I metabolites was Harmol.Conclusion:Harmol is firstly reported as the metabolite.The research illustrates the metabolites of Harmine by using LC-MS, and provides the basis for the further study.